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MBD3L2 encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. Additionally we are shipping Methyl-CpG Binding Domain Protein 3-Like 2 Antibodies (22) and many more products for this protein.
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MBD3L2 is more effective than MBD3 in promoting Tet2 enzymatic activity through strengthening the binding affinity between Tet2 and the methylated DNA target.
These factors lead to a binding affinity hierarchy of p66alpha (show GATAD2A Proteins) for the different MBD2 (show DPEP2 Proteins) homologues (MBD2 (show DPEP2 Proteins) approximately MBD3 (show MBD3 Proteins) > MBD3L1 (show MBD3L1 Proteins) approximately MBD3L2).
MBD3L2 interacts with MBD3 (show MBD3 Proteins) and components of the NuRD complex and can oppose MBD2 (show DPEP2 Proteins)-MeCP1-mediated methylation silencing
This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues.
MBD3-like protein 2
, methyl-CpG-binding domain protein 3-like 2