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The protein encoded by MCM9 is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Additionally we are shipping MCM9 Antibodies (11) and many more products for this protein.
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MCM9 loading onto chromatin is MSH2-dependent, and in turn MCM9 stimulates the recruitment of MLH1 to chromatin, revealing a role for MCM9 and its helicase activity in DNA mismatch repair.
Autosomal-recessive variants in MCM9 cause a genomic-instability syndrome associated with hypergonadotropic hypogonadism (show LHCGR Proteins) and short stature.
Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 (show MCM8 Proteins) and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 (show RAD51 Proteins) recruitment.
A novel alternatively spliced variant of MCM9 is specifically induced after exposure to Mitomycin C. Expression is cell-cycle regulated and induced in S-phase.
Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.
We also show that the very recently reported human MCM9 protein (HsMCM9), which resembles a truncated MCM-like protein missing a part of the MCM2-7 (show MCM2 Proteins) signature domain, is an incomplete form of the full length HsMCM9 described here.
Cdt1 (show CDT1 Proteins), with its two opposing regulatory binding factors MCM9 and geminin (show GMNN Proteins), appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals.
genetic studies of DNA damage response pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9
MCM8 (show MCM8 Proteins) and MCM9 form a complex and that they coregulate their stability.
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1.
DNA helicase MCM9
, DNA replication licensing factor MCM9
, mini-chromosome maintenance deficient domain-containing protein 1
, minichromosome maintenance deficient domain containing 1
, mini-chromosome maintenance deficient 9
, minichromosome maintenance 9
, Mini-chromosome maintenance deficient domain-containing protein 1
, Minichromosome maintenance 9