Minichromosome Maintenance Deficient 9 Proteins (MCM9)

The protein encoded by MCM9 is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Additionally we are shipping MCM9 Antibodies (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCM9 254394 Q9NXL9
MCM9 71567 Q2KHI9
Rat MCM9 MCM9 361852  
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Top MCM9 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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MCM9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Minichromosome Maintenance Deficient 9 (MCM9) Interaction Partners

Human Minichromosome Maintenance Deficient 9 (MCM9) interaction partners

  1. Significant number of potentially damaging and novel variants in MCM9 in primary ovarian insufficiency; multiallelic association with variants in DDR (show DDR1 Proteins) and MCM8 (show MCM8 Proteins)-MCM9 interactome genes.

  2. Study identified fifteen variants that included six common SNPs and nine variants of unknown significance (VUS) in MCM9 gene. However VUS occur in MCM9 in a small proportion of Lynch-like syndrome (LLS) patients and MCM9 mutations are unlikely to explain most LLS cases.

  3. Data show that the two affected sisters were homozygous for the mutation of MCM9 gene, encoding the minichromosome maintenance complex component 9.

  4. MCM9 loading onto chromatin is MSH2-dependent, and in turn MCM9 stimulates the recruitment of MLH1 to chromatin, revealing a role for MCM9 and its helicase activity in DNA mismatch repair.

  5. Autosomal-recessive variants in MCM9 cause a genomic-instability syndrome associated with hypergonadotropic hypogonadism (show LHCGR Proteins) and short stature.

  6. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 (show MCM8 Proteins) and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 (show RAD51 Proteins) recruitment.

  7. A novel alternatively spliced variant of MCM9 is specifically induced after exposure to Mitomycin C. Expression is cell-cycle regulated and induced in S-phase.

  8. Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.

  9. We also show that the very recently reported human MCM9 protein (HsMCM9), which resembles a truncated MCM-like protein missing a part of the MCM2-7 (show MCM2 Proteins) signature domain, is an incomplete form of the full length HsMCM9 described here.

  10. Cdt1 (show CDT1 Proteins), with its two opposing regulatory binding factors MCM9 and geminin (show GMNN Proteins), appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals.

Mouse (Murine) Minichromosome Maintenance Deficient 9 (MCM9) interaction partners

  1. genetic studies of DNA damage response pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9

  2. MCM8 (show MCM8 Proteins) and MCM9 form a complex and that they coregulate their stability.

  3. Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.

  4. Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.

MCM9 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1.

Gene names and symbols associated with MCM9

  • minichromosome maintenance complex component 9 (MCM9)
  • minichromosome maintenance complex component 9 (Mcm9)
  • minichromosome maintenance deficient domain containing 1 (Mcmdc1)
  • 9030408O17Rik protein
  • C6orf61 protein
  • dJ329L24.1 protein
  • dJ329L24.3 protein
  • Gm235 protein
  • MCM9 protein
  • Mcmdc1 protein

Protein level used designations for MCM9

DNA helicase MCM9 , DNA replication licensing factor MCM9 , mini-chromosome maintenance deficient domain-containing protein 1 , minichromosome maintenance deficient domain containing 1 , mini-chromosome maintenance deficient 9 , minichromosome maintenance 9 , Mini-chromosome maintenance deficient domain-containing protein 1 , Minichromosome maintenance 9

GENE ID SPECIES
254394 Homo sapiens
71567 Mus musculus
361852 Rattus norvegicus
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