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anti-Mucolipin 1 (MCOLN1) Antibodies

MCOLN1 encodes a memberof the transient receptor potential (TRP) cation channel gene family. Additionally we are shipping Mucolipin 1 Proteins (3) and Mucolipin 1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MCOLN1 57192 Q9GZU1
MCOLN1 94178 Q99J21
MCOLN1 288371  
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Top anti-Mucolipin 1 Antibodies at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MCOLN1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB MCOLN1 Antibody (C-term) (ABIN657474) western blot analysis in Jurkat ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Brain, cortex 50 μg Log in to see 8 to 10 Days
$676.50
Details
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB Mucolipin 1 antibody used at 0.5 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$510.36
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Sheep Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details

MCOLN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced anti-Mucolipin 1 Antibodies

  1. Mouse (Murine) Polyclonal MCOLN1 Primary Antibody for IHC, WB - ABIN350483 : Bargal, Avidan, Ben-Asher, Olender, Zeigler, Frumkin, Raas-Rothschild, Glusman, Lancet, Bach: Identification of the gene causing mucolipidosis type IV. in Nature genetics 2000 (PubMed)
    Show all 10 references for ABIN350483

  2. Human Polyclonal MCOLN1 Primary Antibody for IHC, WB - ABIN350482 : Bassi, Manzoni, Monti, Pizzo, Ballabio, Borsani: Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. in American journal of human genetics 2000 (PubMed)
    Show all 10 references for ABIN350482

  3. Human Polyclonal MCOLN1 Primary Antibody for IHC, WB - ABIN350480 : Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: The transcriptional landscape of the mammalian genome. ... in Science (New York, N.Y.) 2005 (PubMed)
    Show all 10 references for ABIN350480

  4. Human Polyclonal MCOLN1 Primary Antibody for IHC, WB - ABIN350479 : Falardeau, Kennedy, Acierno, Sun, Stahl, Goldin, Slaugenhaupt: Cloning and characterization of the mouse Mcoln1 gene reveals an alternatively spliced transcript not seen in humans. in BMC genomics 2003 (PubMed)
    Show all 10 references for ABIN350479

  5. Mouse (Murine) Polyclonal MCOLN1 Primary Antibody for IHC, WB - ABIN350481 : Lee, Xu, Chen, Sprung, Kim, Xie, Zhao: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. in Molecular & cellular proteomics : MCP 2007 (PubMed)
    Show all 5 references for ABIN350481

  6. Human Polyclonal MCOLN1 Primary Antibody for IHC (p), WB - ABIN657474 : Eichelsdoerfer, Evans, Slaugenhaupt, Cuajungco: Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN657474

  7. Cow (Bovine) Polyclonal MCOLN1 Primary Antibody for WB - ABIN2776233 : LaPlante, Ye, Quinn, Goldin, Brown, Slaugenhaupt, Vassilev: Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV. in Biochemical and biophysical research communications 2004 (PubMed)

More Antibodies against Mucolipin 1 Interaction Partners

Zebrafish Mucolipin 1 (MCOLN1) interaction partners

  1. study characterized mcoln1.1 and mcoln1.2, the putative co-orthologs of human MCOLN1 gene

Human Mucolipin 1 (MCOLN1) interaction partners

  1. This review summarizes the current understanding of TRPML1 activation and regulation

  2. target of rapamycin (TOR), a nutrient-sensitive protein kinase that negatively regulates autophagy, directly targets and inactivates the TRPML1 channel and thereby functional autophagy, through phosphorylation

  3. lysosomal adaptation to environmental cues such as nutrient levels requires mTOR (show FRAP1 Antibodies)/TFEB (show TFEB Antibodies)-dependent, lysosome-to-nucleus regulation of lysosomal ML1 channels and Ca(2 (show CA2 Antibodies)+) signaling.

  4. TRPML1 has a novel role in protecting against lysosomotropic amine toxicity.

  5. Retinal pigmented epithelial cells develop a punctate phenotype within 48 hours of small interfering (si)RNA-induced TRPML1-knockdown.

  6. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

  7. TRPML1 works in concert with ZnT4 (show SLC30A4 Antibodies) to regulate zinc translocation between the cytoplasm and lysosomes.

  8. findings show that TRPML1-mediated lysosomal Ca(2 (show CA2 Antibodies) ) release is dramatically reduced in Niemann-Pick disease cells; propose that abnormal accumulation of luminal lipids causes secondary lysosome storage by blocking TRPML1- and Ca(2 (show CA2 Antibodies) )-dependent lysosomal trafficking

  9. PI(4,5)P(2) may serve as a negative cofactor for intracellular channels such as TRPML1

  10. an acute siRNA-mediated loss of TRPML1 specifically causes a leak of lysosomal protease cathepsin B (show CTSB Antibodies) (CatB) into the cytoplasm. CatB leak is associated with apoptosis, which can be prevented by CatB inhibition.

Cow (Bovine) Mucolipin 1 (MCOLN1) interaction partners

  1. an NAADP-sensitive Ca(2 (show CA2 Antibodies)+) release channel is characteristic of TRP-ML1 channels

Mouse (Murine) Mucolipin 1 (MCOLN1) interaction partners

  1. Silencing of TRPML1 hindered phagosome fusion with lysosomes.

  2. These results demonstrate that the PtdIns(3,5)P2-Mcoln1 axis has an important role in ssRNA transportation into lysosomes in DCs.

  3. ML1-null mice develop a primary, early-onset muscular dystrophy independent of neural degeneration. Dystrophin-glycoprotein complex and known membrane repair proteins are expressed normally, but membrane resealing was defective in ML1-null muscle fibers.

  4. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

  5. Transfection of CAMs with plasmids containing a full-length TRP-ML1 gene enhanced FasL (show FASL Antibodies)-induced two-phase Ca2 (show CA2 Antibodies)+ release.

  6. Loss of Trpml1 causes reduced levels and mislocalization of the gastric proton pump and alters the secretory canaliculi, causing hypochlorhydria and hypergastrinemia.

  7. This study describes, for the first time, a defect in macroautophagy in mucolipin-1-deficient mouse neurons.

  8. the loss of TRPML1 function results in intracellular chelatable zinc dyshomeostasis.

  9. TRPML1 is expressed in the mouse inner ear.

  10. there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 (show MCOLN2 Antibodies) dictate the localization of TRPML3 (show Mcoln3 Antibodies) and not vice versa

Mucolipin 1 (MCOLN1) Antigen Profile

Protein Summary

This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.

Gene names and symbols associated with anti-Mucolipin 1 (MCOLN1) Antibodies

  • mucolipin 1a (mcoln1a) antibody
  • mucolipin 1 (MCOLN1) antibody
  • mucolipin 1 (mcoln1) antibody
  • mucolipin 1 (LOAG_04987) antibody
  • mucolipin 1 (Mcoln1) antibody
  • 2210015I05Rik antibody
  • MCOLN1 antibody
  • mcoln1.1 antibody
  • MG-2 antibody
  • ML4 antibody
  • MLIV antibody
  • mln1 antibody
  • MST080 antibody
  • mucolipidin antibody
  • mucolipin-1 antibody
  • TRP-ML1 antibody
  • TRPM-L1 antibody
  • TRPML1 antibody
  • zgc:63619 antibody

Protein level used designations for anti-Mucolipin 1 (MCOLN1) Antibodies

mucolipin 1 , mucolipin 1.1 , mucolipidin , mucolipidosis type IV protein , mucolipin-1

GENE ID SPECIES
406689 Danio rerio
426164 Gallus gallus
444113 Xenopus laevis
455656 Pan troglodytes
496811 Xenopus (Silurana) tropicalis
9942391 Loa loa
100601142 Nomascus leucogenys
57192 Homo sapiens
611517 Canis lupus familiaris
505738 Bos taurus
94178 Mus musculus
288371 Rattus norvegicus
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