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N-Myc Downstream Regulated 1 Proteins (NDRG1)

NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping N-Myc Downstream Regulated 1 Antibodies (119) and N-Myc Downstream Regulated 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NDRG1 10397 Q92597
Rat NDRG1 NDRG1 299923 Q6JE36
NDRG1 17988 Q62433
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Top N-Myc Downstream Regulated 1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$309.75
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$273.57
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NDRG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced N-Myc Downstream Regulated 1 Proteins

  1. Human NDRG1 Protein expressed in Escherichia coli (E. coli) - ABIN2006062 : de Zamaroczy, Bernardi: The GC clusters of the mitochondrial genome of yeast and their evolutionary origin. in Gene 1986 (PubMed)
    Show all 2 references for ABIN2006062

  2. Human NDRG1 Protein expressed in Escherichia coli (E. coli) - ABIN666891 : Ellen, Ke, Zhang, Costa: NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. in Carcinogenesis 2008 (PubMed)
    Show all 2 references for ABIN666891

More Proteins for N-Myc Downstream Regulated 1 (NDRG1) Interaction Partners

Human N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. NDRG1 inhibits stemness of colorectal cancer via down-regulation of nuclear beta-catenin (show CTNNB1 Proteins) and CD44 (show CD44 Proteins)

  2. Data suggest that, in colonic/prostatic neoplasm cells, increased expression of NDRG1 decreases activating phosphorylation of FAK and paxillin; silencing/inhibition of NDRG1 results in opposite effect and inhibits neoplasm cell migration/adhesion.

  3. Data indicate that N-myc downstream regulated gene 1 (NDRG1) competitively bind to glycogen synthase kinase 3beta (GSK-3beta) and orphan nuclear receptor (Nur77 (show NR4A1 Proteins)) to prevent beta-catenin (show CTNNB1 Proteins) degradation.

  4. Data suggest that NDRG1 down-regulates expression and activation of HER1/EGFR (show EGFR Proteins), HER2/ERBB2 (show ERBB2 Proteins), and HER3/ERBB3 (show ERBB3 Proteins) in response to epidermal growth factor (EGF (show EGF Proteins)) ligand in pancreatic/colonic neoplasm cells.

  5. pomegranate juice-mediated decrease in cell death in hypoxia is partially mediated by NDRG1 in BeWo cells but not in primary trophoblasts.

  6. Results show that aberrant methylation of NDRG1 promoter is an important mechanism for gene silencing, playing a major role in tumor occurrence and progression of protate cancer (Pca (show FLVCR1 Proteins)). Reversing this process may be used for PCa (show FLVCR1 Proteins) treatment.

  7. NDRG1 could increase the resistance of neuroblastoma (show ARHGEF16 Proteins) cells to chemotherapeutic drugs, with its positive regulation on drug resistant proteins.

  8. NDRG1 decreases phosphorylation of c-Src at Tyr416 by down-regulating EGFR expression and activation. It also affected Rac1, p130Cas, CrkII, and c-Abl. NDRG1 decreases cell migration via c-src inhibition.

  9. Overexpression of NDRG1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT (show AKT1 Proteins) pathways.

  10. TP53 loss leads to abnormal centrosome numbers and genomic instability mediated by NDRG1

Mouse (Murine) N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. Using double knockout of NDR1 (show STK38 Proteins) and 2 shows that NDRs acted downstream of MST1 (show MST1 Proteins) to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.

  2. Ndrg1 is phosphorylated and degraded by CD28 (show CD28 Proteins) signalling in a proteasome-dependent manner.

  3. Ndr1 (show STK38 Proteins)/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR (show STK38 Proteins) kinases are critically required during the early phase of organogenesis

  4. Rassf5 (show RASSF5 Proteins) and Ndr1 (show STK38 Proteins) or Ndr2 (show STK38L Proteins) kinases regulate neuronal polarity through Par3 (show F2RL2 Proteins) phosphorylation.

  5. NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner

  6. early growth response 1 (show EGR1 Proteins), a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2 (show PKD2 Proteins).

  7. Our findings do not support the proposed roles of NDRG1 in growth arrest, terminal differentiation, gene expression regulation and proteasomal degradation.

  8. Nickel induces HIF-1 (show HIF1A Proteins) transactivation and Cap43 protein expression through a PI-3K/Akt (show AKT1 Proteins)-dependent and p70(S6k (show RPS6KB1 Proteins))-independent pathway.

  9. results indicate that NDRG1 deficiency leads to Schwann cell dysfunction, suggesting that NDRG1 is essential for maintenance of the myelin sheaths in peripheral nerves

  10. NDRG1 may play an important role in the terminal differentiation of Schwann cells during nerve regeneration.

Arabidopsis thaliana N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.

  2. SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.

  3. The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.

  4. Sequence analysis and mass spectrometry suggest that NDR1 (show STK38 Proteins) is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI (show GPI Proteins)) anchor.

  5. demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae

  6. Mutations in NDR1 (show STK38 Proteins) abolished the enhanced resistance of dnd (show DND1 Proteins) mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.

N-Myc Downstream Regulated 1 (NDRG1) Protein Profile

Protein Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NDRG1

  • N-myc downstream regulated 1 (NDRG1)
  • N-myc downstream regulated 1 (ndrg1-b)
  • N-myc downstream regulated 1 (Ndrg1)
  • N-myc downstream regulated gene 1 (Ndrg1)
  • N-myc downstream regulated gene 1a (ndrg1a)
  • protein NDR1 (NDR1)
  • cap43 protein
  • cb775 protein
  • cmt4d protein
  • DRG-1 protein
  • drg1 protein
  • gc4 protein
  • hmsnl protein
  • Ndr1 protein
  • ndrg1 protein
  • Ndrl protein
  • nmsl protein
  • NON-RACE SPECIFIC DISEASE RESISTANCE PROTEIN protein
  • non race-specific disease resistance 1 protein
  • proxy1 protein
  • rit42 protein
  • rtp protein
  • targ1 protein
  • tdd5 protein
  • wu:fb60h02 protein
  • xndrg1 protein
  • zgc:63944 protein

Protein level used designations for NDRG1

N-myc downstream regulated gene 1 , N-myc downstream regulated 1 , N-myc downstream-regulated gene 1 protein , differentiation-related gene 1 protein , nickel-specific induction protein Cap43 , protein NDRG1 , protein regulated by oxygen-1 , reducing agents and tunicamycin-responsive protein , protein NDRG1-B , xNDRG1-B , protein Ndr1

GENE ID SPECIES
100068997 Equus caballus
697752 Macaca mulatta
482049 Canis lupus familiaris
10397 Homo sapiens
380319 Xenopus laevis
420321 Gallus gallus
504499 Bos taurus
299923 Rattus norvegicus
464411 Pan troglodytes
17988 Mus musculus
792085 Danio rerio
821607 Arabidopsis thaliana
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