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NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping N-Myc Downstream Regulated 1 Antibodies (160) and N-Myc Downstream Regulated 1 Kits (6) and many more products for this protein.
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Human NDRG1 Protein expressed in Escherichia coli (E. coli) - ABIN2006062
de Zamaroczy, Bernardi: The GC clusters of the mitochondrial genome of yeast and their evolutionary origin. in Gene 1986
Show all 2 references for ABIN2006062
Human NDRG1 Protein expressed in Escherichia coli (E. coli) - ABIN666891
Ellen, Ke, Zhang, Costa: NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. in Carcinogenesis 2008
Show all 2 references for ABIN666891
NDRG1 role in proliferation, invasion and migration of pancreatic cancer
Cell proliferation and invasion effect were remarkably enhanced when NDRG1 was silencing.
NDRG1 appears to prevent epithelial-mesenchymal transition (EMT (show ITK Proteins))-induced metastasis by attenuating NF-kappaB (show NFKB1 Proteins) signaling in metastasis of colorectal cancer (CRC (show CALR Proteins)).
The positive rates of NDRG1expression was 63. 83.33% (40/48)and 27.78% (5/18) in the controls, respectively. High expressions of NDRG1 and VEGF, NDRG1 and VEGF influenced both the occurrence and development of CA
Also, overexpression of AHR facilitated cell proliferation and migration via up-regulation of NDRG1.
NDRG1 inhibits stemness of colorectal cancer via down-regulation of nuclear beta-catenin (show CTNNB1 Proteins) and CD44 (show CD44 Proteins)
Data suggest that, in colonic/prostatic neoplasm cells, increased expression of NDRG1 decreases activating phosphorylation of FAK and paxillin; silencing/inhibition of NDRG1 results in opposite effect and inhibits neoplasm cell migration/adhesion.
Data indicate that N-myc downstream regulated gene 1 (NDRG1) competitively bind to glycogen synthase kinase 3beta (GSK-3beta) and orphan nuclear receptor (Nur77 (show NR4A1 Proteins)) to prevent beta-catenin (show CTNNB1 Proteins) degradation.
Data suggest that NDRG1 down-regulates expression and activation of HER1/EGFR (show EGFR Proteins), HER2/ERBB2 (show ERBB2 Proteins), and HER3/ERBB3 (show ERBB3 Proteins) in response to epidermal growth factor (EGF (show EGF Proteins)) ligand in pancreatic/colonic neoplasm cells.
pomegranate juice-mediated decrease in cell death in hypoxia is partially mediated by NDRG1 in BeWo cells but not in primary trophoblasts.
NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.
Using double knockout of NDR1 (show STK38 Proteins) and 2 shows that NDRs acted downstream of MST1 (show MST1 Proteins) to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.
Ndrg1 is phosphorylated and degraded by CD28 (show CD28 Proteins) signalling in a proteasome-dependent manner.
Ndr1 (show STK38 Proteins)/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR (show STK38 Proteins) kinases are critically required during the early phase of organogenesis
Rassf5 (show RASSF5 Proteins) and Ndr1 (show STK38 Proteins) or Ndr2 (show STK38L Proteins) kinases regulate neuronal polarity through Par3 (show F2RL2 Proteins) phosphorylation.
NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner
early growth response 1 (show EGR1 Proteins), a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2 (show PKD2 Proteins).
Our findings do not support the proposed roles of NDRG1 in growth arrest, terminal differentiation, gene expression regulation and proteasomal degradation.
Nickel induces HIF-1 (show HIF1A Proteins) transactivation and Cap43 protein expression through a PI-3K/Akt (show AKT1 Proteins)-dependent and p70(S6k (show RPS6KB1 Proteins))-independent pathway.
results indicate that NDRG1 deficiency leads to Schwann cell dysfunction, suggesting that NDRG1 is essential for maintenance of the myelin sheaths in peripheral nerves
NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.
SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.
The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.
Sequence analysis and mass spectrometry suggest that NDR1 (show STK38 Proteins) is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI (show GPI Proteins)) anchor.
demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae
Mutations in NDR1 (show STK38 Proteins) abolished the enhanced resistance of dnd (show DND1 Proteins) mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
N-myc downstream regulated gene 1
, N-myc downstream regulated 1
, N-myc downstream-regulated gene 1 protein
, differentiation-related gene 1 protein
, nickel-specific induction protein Cap43
, protein NDRG1
, protein regulated by oxygen-1
, reducing agents and tunicamycin-responsive protein
, protein NDRG1-B
, protein Ndr1