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The protein encoded by NLRP6 binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. Additionally we are shipping and many more products for this protein.
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this review discuss recent findings related to NLRP6 activity, while highlighting outstanding questions and future perspectives in elucidating its roles in health and disease
Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2 (show TAB2 Antibodies)/3 and TRIM38 (show TRIM38 Antibodies) in RA synoviocytes in response to TNFalpha (show TNF Antibodies). (NLRP6 = ; TAB2 (show TAB2 Antibodies)/3 = transforming growth factor-b (show ATP5S Antibodies)-activated kinase 1-binding protein 2/3; TRIM38 (show TRIM38 Antibodies) = tripartite motif 38)
Our results revealed an association between NLRP6/AVR and ADM (show ADM Antibodies) loci with male essential hypertension, suggesting the existence of sex-specific NLRP6/AVR and ADM (show ADM Antibodies) variants affecting male susceptibility to essential hypertension.
We will focus on NLRP6 and NLRP12 (show NLRP12 Antibodies).
NLRP6 is a newly characterized member of this family that inhibits NF-kappaB (show NFKB1 Antibodies) and MAP-kinase (show MAPK1 Antibodies) dependent immune signaling to hamper anti-microbial defense.
AVR is distinct from Nalp6/PYPAF5 based on different mRNA and protein sizes, subcellular localization, and tissue-specific expression patterns.
The dual AngII/AVP (show AVP Antibodies) receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model.
This publication deals with the rat ortholog of the human NLRP6 gene.
A. actinomycetemcomitans enhances NLRP3 (show NLRP3 Antibodies) and reduces NLRP6 inflammasome expression.
this study shows that Nlrp6-dependent Inflammasomes do not shape the commensal gut (show GUSB Antibodies) microbiota composition
Study identified a set of microbiota-modulated metabolites whose integrative activity drives NLRP6 inflammasome activation and downstream epithelial IL-18 (show IL18 Antibodies)-induced anti-microbial peptide secretion, thereby providing favorable conditions for WT microbiota colonization.
Nlrp6 contributes to recovery from peripheral nerve injury by dampening inflammatory responses independently of IL-1beta (show IL1B Antibodies) and inflammasomes
These data demonstrate that Nlrp6 functions with Dhx15 (show DHX15 Antibodies) as a viral RNA sensor to induce IFN-stimulated genes , and this effect is especially important in the intestinal tract.
Study demonstrates that NLRP6 is important in maintaining autophagy in the intestinal epithelium, a process previously shown to be critically important in intestinal granule exocytosis pathway.
Exposure of mice to stress inhibits NLRP6 and alters the composition of the gut (show GUSB Antibodies) microbiota, leading to intestinal inflammation.
This publication deals with the rat ortholog of the mouse Nlrp6 gene.
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation.
NLR family, pyrin domain containing 6
, NACHT, leucine rich repeat and PYD containing 6
, NLR family pyrin domain-containing protein 6
, NACHT, LRR and PYD domains-containing protein 6-like
, NACHT, LRR and PYD containing protein 6
, NACHT, LRR and PYD domains-containing protein 6
, PYRIN-containing APAF1-like protein 5
, angiotensin II/vasopressin receptor
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6
, NACHT/LRR/pyrin domain-containing protein 6
, non-angiotensin-vasopressin receptor
, angiotensin/vasopressin receptor
, dual angiotensin II/vasopressin receptor