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Nephroblastoma Overexpressed Proteins (NOV)

The protein encoded by NOV is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. Additionally we are shipping Nephroblastoma Overexpressed Antibodies (83) and Nephroblastoma Overexpressed Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NOV 4856 P48745
NOV 81526 Q9QZQ5
NOV 18133 Q64299
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Top Nephroblastoma Overexpressed Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$657.80
Details
HOST_Baculovirus infected Insect Cells Cynomolgus His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Dog His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_CHO Cells Human Un-conjugated   10 μg Log in to see 2 to 3 Days
$168.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 7 to 9 Days
$328.21
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,874.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,889.33
Details

NOV Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Rat (Rattus)

Mouse (Murine) ,

Top referenced Nephroblastoma Overexpressed Proteins

  1. Human NOV Protein expressed in Wheat germ - ABIN1312819 : Janune, Kubota, Nishida, Kawaki, Perbal, Iida, Takigawa: Novel effects of CCN3 that may direct the differentiation of chondrocytes. in FEBS letters 2011 (PubMed)
    Show all 2 references for ABIN1312819

More Proteins for Nephroblastoma Overexpressed (NOV) Interaction Partners

Human Nephroblastoma Overexpressed (NOV) interaction partners

  1. Studies indicate that the CYR61 (show CYR61 Proteins) CTGF (show CTGF Proteins) NOV matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Proteins), CCN2 (show CTGF Proteins), CCN3, CCN4 (show WISP1 Proteins), CCN5 (show WISP2 Proteins) and CCN6 (show WISP3 Proteins) and have been identified in various types of cancer.

  2. NOV expression was highly increased in biopsies of patients with tubulointerstitial nephritis.

  3. Results revealed that NOV regulates the tumor growth of osteosarcoma cells through activation of the MAPK (show MAPK1 Proteins) signaling pathway and promotes osteosarcoma cell migration in vitro.

  4. our results argue that MZF-1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma.

  5. Overexpression of CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment.

  6. NOV may promote carcinogenesis via promotion of EMT (show ITK Proteins) and association with increased mTOR (show FRAP1 Proteins) activity

  7. CCN3 can promote dentinogenesis by coordinating proliferation and odontoblastic differentiation of dental pulp stem cells via modulating Notch (show NOTCH1 Proteins) and BMP2 (show BMP2 Proteins) signaling pathways.

  8. over-expression of NOV in pancreatic cancer cells promoted cell proliferation and migration, while knock down the expression of NOV impaired the tumorigenecity of pancreatic cancer cells in vitro and in vivo

  9. CCN3 may play an important role in cervical carcinogenesis and therefore may have potential as a biomarker for prognosis and as a therapeutic target in cervical cancer.

  10. Our findings establish a tumor-suppressive role of NOV in prostate cancer

Mouse (Murine) Nephroblastoma Overexpressed (NOV) interaction partners

  1. Study showed that progenitor cells lining the telencephalic ventricles express PlexinA1 (show PLXNA1 Proteins) and that absence of this receptor impairs neurogenesis in the developing forebrain

  2. Genetic and pharmacological approaches implicated the ERK1/2 pathway as a critical regulator of CCN3-dependent AAA (show AAAS Proteins) development.

  3. Reduced NOV expression limits inflammation and interstitial renal fibrosis after obstructive nephropathy in mice.

  4. NOV is required for the maintenance of articular cartilage and for joint homeostasis, with disruption of NOV in ageing Nov(del3)-/- male mice causing osteoarthritis-like disease.

  5. tight regulation of CCN3 expression is necessary for normal cortical neuronal connectivity during development, and RAB25 (show RAB25 Proteins) negatively regulates neuronal differentiation as a downstream effector of CCN3

  6. CCN3 overexpression is associated with control of inflammatory processes and reversion of dyslipidemia in the process of atherosclerosis, which implies that CCN3 may be a promising target in the treatment of atherosclerosis.

  7. PlexinA1 (show PLXNA1 Proteins) mediates both Semaphorin and Slit signaling

  8. genetic findings demonstrate that Sema3a (show SEMA3A Proteins) repellent signaling plays a role in the establishment of proper afferent projections in SAG (show RNF7 Proteins) neurons, and this signaling likely occurs through a receptor complex involving Npn1 (show NRP1 Proteins) and either plexinA1 (show PLXNA1 Proteins) or plexinA3 (show PLXNA3 Proteins)

  9. A novel direct interaction between the Sema3a (show SEMA3A Proteins) signaling receptor plexinA1 (show PLXNA1 Proteins) and nephrin (show NPHS1 Proteins), linking extracellular Sema3a (show SEMA3A Proteins) signals to the slit-diaphragm signaling complex, was identified.

  10. in obese humans and mice plasma NOV levels positively correlated with NOV expression in adipose tissue, and support a possible contribution of NOV to obesity-related inflammation.

Nephroblastoma Overexpressed (NOV) Protein Profile

Protein Summary

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.

Gene names and symbols associated with NOV

  • nephroblastoma overexpressed (NOV)
  • nephroblastoma overexpressed (Nov)
  • nephroblastoma overexpressed (nov)
  • nephroblastoma overexpressed gene (NOV)
  • nephroblastoma overexpressed gene (Nov)
  • plexin A1 (Plxna1)
  • 2600013D04Rik protein
  • C130088N23Rik protein
  • CCN3 protein
  • IBP-9 protein
  • IGFBP-9 protein
  • IGFBP9 protein
  • mKIAA4053 protein
  • NOV protein
  • nov-A protein
  • NovH protein
  • PlexA1 protein
  • Plxn1 protein
  • xnov protein

Protein level used designations for NOV

CCN family member 3 , IGF-binding protein 9 , insulin-like growth factor-binding protein 9 , nephroblastoma-overexpressed gene protein homolog , protein NOV homolog , nephroblastoma overexpressed gene protein homolog , novH , nephroblastoma overexpressed gene protein , nephroblastoma-overexpressed gene protein , protein NOV , plex 1 , plexin 1 , plexin-1 , plexin-A1

GENE ID SPECIES
4856 Homo sapiens
81526 Rattus norvegicus
373662 Xenopus laevis
475083 Canis lupus familiaris
505727 Bos taurus
18133 Mus musculus
396204 Gallus gallus
18844 Mus musculus
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