NOV Protein (AA 32-357)
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- Target See all NOV Proteins
- NOV (Nephroblastoma Overexpressed (NOV))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 32-357
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Origin
- Human
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Source
- CHO Cells
- Characteristics
- ED50 < 5 μg/mL, measured in a cell proliferation assay using 3T3 cells.
- Purity
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product NOV Protein
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Nephroblastoma Overexpressed (NOV) (AA 1-357) protein (GST tag)
NOV Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nephroblastoma Overexpressed (NOV) protein (His tag)NOV Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Nephroblastoma Overexpressed (NOV) (AA 28-357) protein (His tag)NOV Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Nephroblastoma Overexpressed (NOV) (AA 32-131) protein (GST tag)NOV Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nephroblastoma Overexpressed (NOV) (AA 32-357) protein (His tag)Crystallography grade NOV Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Nephroblastoma Overexpressed (NOV) (AA 22-354) protein (His tag)Crystallography grade NOV Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant Human NOV remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human NOV should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- NOV (Nephroblastoma Overexpressed (NOV))
- Alternative Name
- Nephroblastoma Overexpressed Gene Protein (NOV) (NOV Products)
- Synonyms
- CCN3 Protein, IBP-9 Protein, IGFBP-9 Protein, IGFBP9 Protein, NOVh Protein, nov-A Protein, xnov Protein, NovH Protein, C130088N23Rik Protein, nephroblastoma overexpressed Protein, nephroblastoma overexpressed L homeolog Protein, nephroblastoma overexpressed gene Protein, NOV Protein, nov.L Protein, Nov Protein
- Background
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Nephroblastoma Overexpressed Gene Protein (NOV), also known as CCN3, IGFBP9 and NOVH, is one of the CCN family of secreted proteins. It is expressed in bone marrow, thymic cells and nephroblastoma. NOV signals through integrin receptors, NOTCH1 and fibulin 1c to regulate multiple cellular activities, such as cell adhesion, migration, proliferation and differentiation. The reported functions of NOV are diverse. It has been reported to play a role in angiogenesis and stem cell self-renewal. It has also been implicated in osteogenic differentiation, embryo development and cancer pathogenesis.
Synonyms: Nephroblastoma Overexpressed gene, CCN3, IGFBP9, NovH - Molecular Weight
- 20-50 kDa, observed by reducing SDS-PAGE.
- UniProt
- P48745
- Pathways
- Smooth Muscle Cell Migration, Growth Factor Binding
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