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anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) Antibodies

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Additionally we are shipping NUDT15 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NUDT15 55270 Q9NV35
NUDT15 214254 Q8BG93
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Top anti-NUDT15 Antibodies at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Immunohistochemistry analysis in human breast tissuee (Formalin-fixed, Paraffin-embedded) using NUDT15  Antibody  (C-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the NUDT15 antibody  for IHC. Clinical relevance has not been evaluated. Western blot analysis in HepG2 cell line lysates (35ug/lane) using NUDT15  Antibody (C-term). This demonstrates the NUDT15 antibody detected the NUDT15 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB NUDT15 antibody (C-term) (ABIN654983) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissuee followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit APC FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit APC FACS, IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit FITC FACS, IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

NUDT15 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,


, , , , ,
Mouse (Murine)


Top referenced anti-NUDT15 Antibodies

  1. Human Polyclonal NUDT15 Primary Antibody for EIA, FACS - ABIN953779 : Hori, Satou, Harashima, Kamiya: Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. in Free radical biology & medicine 2010 (PubMed)
    Show all 2 references for ABIN953779

More Antibodies against NUDT15 Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) interaction partners

  1. NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.

  2. Patients with defective NUDT15 alleles showed excessive levels of thiopurine active metabolites and toxicity. [meta-analysis]

  3. Depletion of NUDT15 has no effect on incorporation of 8-oxo-dGTP into DNA and does not impact cancer cell survival in cell lines tested. NUDT15 is not a biologically relevant 8-oxo-dGTPase (show NUDT1 Antibodies)

  4. Event-free survival did not significantly differ by NUDT15 genotype. rs116855232 is an important determinant of 6-MP myelotoxicity in Japanese children with ALL and may represent the most robust toxicity-related locus in Asians to date.

  5. Describe a germline variant in NUDT15 strongly associated with mercaptopurine intolerance in childhood acute lymphoblastic leukemia, which may have implications for treatment individualization in this disease.

  6. Authros identified a nonsynonymous SNP in NUDT15 (encoding p.Arg139Cys) that was strongly associated with thiopurine-induced early leukopenia (odds ratio (OR) = 35.6; P(combined) = 4.88 x 10(-94)).

  7. human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP.

  8. Data demonstrate for the first time that PCNA (show PCNA Antibodies) is protected by this newly identified partner molecule MTH2, which is related to DNA synthesis and cell cycle progression.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) interaction partners

  1. These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.

  2. MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 (show NUDT1 Antibodies) redundancy factor [MTH2]

NUDT15 Antigen Profile

Protein Summary

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.

Gene names and symbols associated with NUDT15

  • nudix (nucleoside diphosphate linked moiety X)-type motif 15 (NUDT15) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 15 (Nudt15) antibody
  • 6530403O17 antibody
  • A730068G11Rik antibody
  • MTH2 antibody
  • RP11-90M2.1 antibody

Protein level used designations for NUDT15

7,8-dihydro-8-oxoguanine-triphosphatase NUDT15 , 8-oxo-dGTPase NUDT15 , A730068G11Rik , mutT homolog 2 , nucleoside diphosphate-linked moiety X motif 15 , nudix motif 15 , nudix-type motif 15 , probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 , probable 8-oxo-dGTP diphosphatase NUDT15 , MutT homolog 2 , mMTH2

GENE ID SPECIES
55270 Homo sapiens
214254 Mus musculus
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