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The protein encoded by NUMB plays a role in the determination of cell fates during development. Additionally we are shipping NUMB Proteins (11) and NUMB Kits (1) and many more products for this protein.
Showing 10 out of 181 products:
Cow (Bovine) Polyclonal NUMB Primary Antibody for EIA, IF - ABIN374158
Sczaniecka, Gladstone, Pettersson, McLaren, Huart, Wallace: MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism. in The Journal of biological chemistry 2012
Show all 8 references for ABIN374158
Human Polyclonal NUMB Primary Antibody for EIA, IHC (p) - ABIN953787
Rennstam, McMichael, Berglund, Honeth, Hegardt, Rydén, Luts, Bendahl, Hedenfalk: Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer. in Breast cancer research and treatment 2010
Show all 5 references for ABIN953787
Human Polyclonal NUMB Primary Antibody for ELISA, WB - ABIN184679
Zhong, Feder, Jiang, Jan, Jan: Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. in Neuron 1996
Show all 3 references for ABIN184679
Human Polyclonal NUMB Primary Antibody for EIA, WB - ABIN783468
Wu, Kwon, Rattis, Blum, Zhao, Ashkenazi, Jackson, Gaiano, Oliver, Reya: Imaging hematopoietic precursor division in real time. in Cell stem cell 2008
Show all 2 references for ABIN783468
Human Polyclonal NUMB Primary Antibody for IHC (p), WB - ABIN655396
Kyriazis, Wei, Vandermey, Jo, Xin, Mattson, Chan: Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. in The Journal of biological chemistry 2008
Human Polyclonal NUMB Primary Antibody for IF (p), IHC (p) - ABIN744428
Mah, Soloff, Hedrick, Mariani: Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. in Stem cell reports 2015
role in the mediation of TCR degradation
miR (show MLXIP Antibodies)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (show NOTCH1 Antibodies) to separate stem and non-stem cell fates robustly.
Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (show TLR4 Antibodies).
Loss of Numb induces a p53 (show TP53 Antibodies)-dependent senescence following skeletal muscle injury.
Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (show GRM1 Antibodies).
we observed a glial reaction and an activity-dependent modification of Shh (show SHH Antibodies), Noggin (show NOG Antibodies), and Numb proteins. we found that Shh (show SHH Antibodies) and Noggin (show NOG Antibodies) could affect motor performance and that these proteins could be associated with both TDP-43 (show TARDBP Antibodies) and Numb
Numb ensures the asymmetric outcome of self-renewing divisions by partitioning into the progeny that retains the stem cell identity, where it sustains high p53 (show TP53 Antibodies) activity.
findings demonstrate that Nb and Nbl are intrinsic factors crucial for the renewal of CPCs in the PA2 and that the PA2 serves as a microenvironment for their expansion
Numb/Numbl (show NUMBL Antibodies) control VEGF receptor (show FLT1 Antibodies) endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels.
Nuclear localization of Numb in early thymocyte precursors favors p53 (show TP53 Antibodies) nuclear stabilization, whereas pre-T-cell receptor (show PTCRA Antibodies)-dependent Numb nuclear exclusion promotes the p53 (show TP53 Antibodies) downmodulation essential for further differentiation.
High expression of Numb is associated with radiation resistance in pancreatic cancer.
Upregulated expression of Numb is associated with reduced radiosensitivity of lung cancer.
Radiation sensitivity of NSCLC stem cells was enhanced with the increase of Numb expression.
PNA-antimiR-182 reduced the levels of NICD (show NOTCH1 Antibodies), Hes1, HIF-1alpha (show HIF1A Antibodies), and p-Akt (show AKT1 Antibodies) in both cell groups, while it augmented the intracellular content of FOXO1 (show FOXO1 Antibodies) and Numb suppressor proteins. In other words, PNA-antimiR-182-mediated upregulation of Numb was associated with downregulation of HIF-1alpha (show HIF1A Antibodies) and Hes1. Consequently, downregulation of miR (show MLXIP Antibodies)-182 might find therapeutical value for overcoming trastuzumab resistance
Dominant negative NUMB expression confers a high proliferative phenotype to chronic myeloid leukemia (show BCL11A Antibodies) cells.
Alternative splicing of APP (show APP Antibodies), VEGFA (show VEGFA Antibodies) and NUMB may play an important role in pathogenesis of pancreatic ductal adenocarcinoma.
Notch1 (show NOTCH1 Antibodies)/Numb/Snail (show SNAI1 Antibodies) signal pathway plays an important role in the pathogenesis of adenomyosis.
Numb polymorphisms are associated with coronary artery disease among Han Chinese and Uighur Chinese in Xinjiang, China.
Methylation of the Numb promoter contributed to hepatocarcinogenesis.
results indicated that both rs2108552 and rs17781919 in the Numb gene were associated with total cholesterol level and density lipoprotein-cholesterol level in Chinese subjects.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
protein numb homolog
, numb gene homolog