anti-Opsin 4 (OPN4) Antibodies

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. Additionally we are shipping OPN4 Kits (4) and OPN4 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OPN4 192223 Q8R456
OPN4 94233 Q9UHM6
OPN4 30044 Q9QXZ9
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Top anti-OPN4 Antibodies at

Showing 10 out of 22 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using OPN4 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, IF, WB Western Blot (WB) analysis of specific lysis using Melanopsin Polyclonal Antibody. 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated WB Western blot analysis of Melanopsin expression in HEK293T (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC, WB Figure 1 shows immunofluorescence staining of melanopsin in rat retinal ganglion cells using ABIN261558. Immunocytochemistry/Immunofluorescence: Melanopsin Antibody [ABIN2615580] - Staining in rat retinal ganglion cells. 0.1 mg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Melanopsin Antibody [NBP1-92105] - Staining of human placenta shows strong membrane positivity in trophoblastic cells. 0.1 mL Log in to see 18 to 20 Days
Human Rabbit Un-conjugated ICC, IF, WB Western Blot: Melanopsin Antibody [NBP1-00923] - Western blot (WB) analysis of Melanopsin (L470) antibody in extracts from COLO cells 0.1 mL Log in to see 7 to 9 Days

OPN4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)

Human ,

Mouse (Murine)

More Antibodies against OPN4 Interaction Partners

Zebrafish Opsin 4 (OPN4) interaction partners

  1. Melanopsin photostimulation triggers the phosphoinositide pathway through activation of a G-Protein, G11 (show STK19 Antibodies).

  2. The opn4.1 gene is not expressed in the brain until 3 dpf, when transcripts are located at the juncture between the caudal (show CAD Antibodies) hindbrain and anterior spinal cord, in cells in the ventricular region.

  3. description of the discovery and functional characterisation of a new melanopsin gene in fish, bird, and amphibian genomes, demonstrating that vertebrates have evolved two quite separate melanopsins

Turkey Opsin 4 (OPN4) interaction partners

  1. Expressed locally in the premammillary nucleus of the hypothalamus in temperate zone birds, melanopsin is an important regulator of reproductive activity.

Human Opsin 4 (OPN4) interaction partners

  1. The wide distribution of OPN4 in central areas of the human brain evokes a question whether ambient light has important straight targets in the human brain outside the retinohypothalamic tract.

  2. Trait-like individual differences in the melanopsin phototransduction circuitry contribute to individual differences in sleep timing. Blue light-sensitive young individuals are more prone to delayed sleep.

  3. The light-induced FOS response in melanopsin expressing HEK (show EPHA3 Antibodies)-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance.

  4. By broadening the tuning of intrinsically photosensitive retinal ganglion cells, melanopsin tristability produces signal integration.

  5. The response of the human pupil to the separate stimulation of the cones and melanopsin at a range of temporal frequencies under photopic conditions, was measured.

  6. Studied OPN4*Ile394Thr gene polymorphism in association with sleep/wake timing.

  7. The results of this study showed that the post illumination pupil response varied on the basis of OPN4 I394T genotype among individuals with seasonal affective disorder.

  8. Studied the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths.

  9. A comparison of melanopsin with the mechanisms documented for vertebrate (bovine) and invertebrate (squid) visual photoreceptors shows that such a mechanism is not affected by the diversity of the three chromophore cavities.

  10. An action spectrum for the calcium response in cells expressing human melanopsin had the predicted form for an opsin (show RHO Antibodies) : vitamin A1 pigment and peaked at 479 nm. The G-protein selectivity and spectral sensitivity of human melanopsin is similar to that previously described for rodents.

Mouse (Murine) Opsin 4 (OPN4) interaction partners

  1. Melanopsin contributes to irradiance modulation of narrowband oscillations in the retina and dorsal lateral geniculate nucleus.

  2. discovery that amino acid sequence features of melanopsin protein contribute to the functional properties of the intrinsically photosensitive retinal ganglion cells

  3. When compared with wildtype responses, sleep onset in melanopsin (OPN4-/-) mice was significantly advanced under blue light, whereas under violet and green light it was significantly delayed.

  4. Melanopsin overexpression in RGCs enhanced the amplitude and duration of their light response, and silencing them with Kir2.1 (show KCNJ2 Antibodies) significantly suppressed the increased mTOR (show FRAP1 Antibodies) signaling and axon regeneration that were induced by melanopsin

  5. mice null for melanopsin (Opn4-/-), lost significantly more weight than wild-type controls or mice lacking rod and cone photoreceptors.

  6. These results suggest GRK2 (show ADRBK1 Antibodies) contributes to melanopsin deactivation, but that other mechanisms account for most of modulation of melanopsin activity in ipRGCs.

  7. Using a combination of conventional knockout, chemogenetic, and receptor-silent substitution manipulations, we continued to show that, over higher irradiances, this increase in firing originates with inner-retinal melanopsin photoreception

  8. Opn4 mediates wavelength-specific, light-dependent vascular relaxation.

  9. Data indicate that retinal molecular circadian clock can be entrained by lighting cycles in vitro, but that rods, cones, and melanopsin (Opn4) are not required for this entrainment.

  10. critical phosphorylation sites on the carboxy tail of melanopsin

OPN4 Antigen Profile

Protein Summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with anti-Opsin 4 (OPN4) Antibodies

  • opsin 4.1 (opn4.1) antibody
  • opsin 4 (OPN4) antibody
  • melanopsin (LOC100303707) antibody
  • melanopsin-B-like L homeolog (LOC100485437.L) antibody
  • opsin 4a (melanopsin) (opn4a) antibody
  • opsin 4 (Opn4) antibody
  • opsin 4 (melanopsin) (Opn4) antibody
  • 1110007J02Rik antibody
  • cOpn4L antibody
  • Gm533 antibody
  • melanopsin antibody
  • MOP antibody
  • opn4 antibody
  • OPN4-2 antibody
  • opn4-A antibody
  • opn4d antibody
  • opn4l antibody
  • opn4m2 antibody
  • Xmop antibody

Protein level used designations for anti-Opsin 4 (OPN4) Antibodies

melanopsin opn4m2 , melanopsin-like , opn4c , opsin 4 (melanopsin) , opsin 4, like , melanopsin , melanopsin 2 , opsin 4 like , putative Opsin 4 , opsin 4 , putative photopigment melanopsin , mammalian-like melanopsin , melanopsin opn4m1 , melanopsin-A , melanopsin-M , opn4m1 , opsin-4-A , opsin-4M , opsin-4

352918 Danio rerio
423609 Gallus gallus
515152 Bos taurus
611027 Canis lupus familiaris
735531 Pan troglodytes
100303707 Meleagris gallopavo
373689 Xenopus laevis
571624 Danio rerio
192223 Rattus norvegicus
94233 Homo sapiens
493921 Felis catus
30044 Mus musculus
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