You are viewing an incomplete version of our website. Please click to reload the website as full version.

PTK2 Protein tyrosine Kinase 2 Proteins (PTK2)

PTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Additionally we are shipping FAK Antibodies (650) and FAK Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top FAK Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Chicken GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human His tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus Human GST-His-Tag   10 μg Log in to see 1 to 2 Days
$443.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

PTK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Rat (Rattus)
Mouse (Murine)

More Proteins for PTK2 Protein tyrosine Kinase 2 (PTK2) Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. Data suggest that simultaneous targeting of mammalian target of rapamycin (mTOR (show FRAP1 Proteins))- and adhesion kinase (FAK)-related pathways might offer a strategy for treating acute lymphoblastic leukemia (ALL).

  2. it was also observed that miR-7 (show LILRB1 Proteins) regulated the proliferation and migration of colon cancer by regulating the protein expression of FAK, therefore, regulating the expression of matrix metalloproteinase (MMP)-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins)

  3. Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle

  4. CEP-37440 decreased the cell proliferation of FC-IBC02, SUM190, and KPL4 by blocking the autophosphorylation kinase activity of FAK1 (Tyr (show TYR Proteins) 397).

  5. Bit1 (show PTRH2 Proteins) may be an important regulator in cell growth, apoptosis, migration and invasion of esophageal squamous cell carcinoma via targeting FAK-paxillin (show PXN Proteins) pathway.

  6. In human colon cancer cells, Akt1 (show AKT1 Proteins) binds focal adhesion kinase via the Akt1 kinase (show AKT1 Proteins) domain independently of the pleckstrin (show PLEK Proteins) homology domain

  7. FAK enhances glycolysis and decreases mitochondrial respiration and increases key glycolytic proteins. Active/tyrosine-phosphorylated FAK directly binds to PKM2 and promotes PKM2-mediated glycolysis.

  8. Our findings suggest that the targets of FAK play a key role in metastasis

  9. Data suggest that, in colonic/prostatic neoplasm cells, increased expression of NDRG1 decreases activating phosphorylation of FAK and paxillin; silencing/inhibition of NDRG1 results in opposite effect and inhibits neoplasm cell migration/adhesion.

  10. Collectively, our data demonstrate that DCMF induces cell migration and promotes wound healing through activation of Src (show SRC Proteins)/FAK, ERK (show EPHB2 Proteins), AKT (show AKT1 Proteins), and p38 MAPK (show MAPK14 Proteins) signaling.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  2. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  3. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  4. These data suggest an important role for the FERM domain in the activation of FAK.

  5. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Proteins), while phosphorylation at Y925 controls the rate of point contact turnover.

  6. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  7. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. results suggest that LPS (show TLR4 Proteins)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Proteins) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Proteins) on osteoblast performance

  2. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

  3. data indicate that PTPalpha (show PTPRA Proteins) and FAK, which are enriched in FAs (show FAS Proteins), interact with IP3R1 (show ITPR1 Proteins) at adjacent ER sites to spatially sequester IL-1 (show IL1A Proteins)-induced Ca(2 (show CA2 Proteins)+) signalling

  4. FAK-regulated signalling module PDK1 (show PDPK1 Proteins)-Akt (show AKT1 Proteins)-p70S6K (show RPS6KB1 Proteins) that controls Src's intracellular trafficking operates at Src (show SRC Proteins)-containing autophagosomes.

  5. Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.

  6. FAK deletion correlates with increased phosphorylation of Tks-5 (tyrosine kinase substrate with five SH3 domain) and reactive oxygen species production.

  7. Par4 (show F2RL3 Proteins), CEBPB (show CEBPB Proteins) and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT (show ITK Proteins) and self-renewal

  8. LPS (show TLR4 Proteins)-induced increases in intestinal TJP and intestinal inflammation were regulated by TLR4 (show TLR4 Proteins)-dependent activation of the FAK/MyD88 (show MYD88 Proteins)/IL-1R-associated kinase 4 signaling pathway.

  9. Inactivation of the FAK signaling pathway by either genetic or pharmacologic methods significantly sensitizes both murine and human PTEN-null T-ALL cells to PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) inhibition when cultured in vitro on feeder layer cells or a matrix and in vivo

  10. These data indicate that FAK might exaggerate NMDAR (show GRIN1 Proteins)-mediated synaptic transmission in the spinal dorsal horn to sensitize nociceptive behaviors.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK activation in response to shear stress.

  2. XIAP (show XIAP Proteins) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C

  4. These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Proteins)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Proteins)-induced vascular smooth muscle cell migration.

FAK (PTK2) Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Gene names and symbols associated with PTK2

  • PTK2 protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (Ptk2)
  • protein tyrosine kinase 2 (ptk2)
  • PTK2 protein tyrosine kinase 2 (Ptk2)
  • Fadk protein
  • FAK protein
  • FAK1 protein
  • FRNK protein
  • mKIAA4203 protein
  • p125FAK protein
  • pp125FAK protein
  • PPP1R71 protein

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

GENE ID SPECIES
100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
Selected quality suppliers for FAK Proteins (PTK2)
Did you look for something else?