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PTK2 Protein tyrosine Kinase 2 Proteins (PTK2)

PTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Additionally we are shipping FAK Antibodies (679) and FAK Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152
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Top FAK Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Chicken GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human His tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus Human GST-His-Tag   10 μg Log in to see 1 to 2 Days
$466.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

PTK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Rat (Rattus)
Mouse (Murine)

More Proteins for PTK2 Protein tyrosine Kinase 2 (PTK2) Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. Periostin (show POSTN Proteins) expression in human periodontal ligament fibroblasts promotes the migration of human mesenchymal stem cells through the alphavbeta3 integrin/FAK/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway in vitro.

  2. High FAK expression is associated with cervical cancer.

  3. Studies propose that localization of FAK Y407, rather than FAK expression and overall FAK Y407 phosphorylation levels, is crucial for the control of cell motility of triple-negative breast cancer (TNBC) cell lines and suggest that subcellular localization, next to expression and activity levels, are important for understanding TNBC progression.

  4. FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.

  5. Identify integrin alphavbeta3 (show ITGAV Proteins) as a receptor ofNC1 domain of collagen XIX. NC1(XIX) inhibits the FAK/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway, by decreasing the phosphorylation and activity of the major proteins involved in this pathway.

  6. Low GAS7C increases cancer cell motility by promoting N-WASP (show WASL Proteins)/FAK/F-actin cytoskeleton dynamics. It also enhances beta-catenin (show CTNNB1 Proteins) stability via hnRNP U (show HNRNPU Proteins)/beta-TrCP (show BTRC Proteins) complex formation.

  7. analysis of a novel mechanism that regulates the expression of FAK via miR138 in Ewing's sarcoma cells

  8. FAK-regulated SRC_SH2 domain plays an important role in directing SRC (show SRC Proteins) into FAs (show FAS Proteins) and that this SRC (show SRC Proteins)-mediated FA signaling drives cell migration.

  9. Data suggest that simultaneous targeting of mammalian target of rapamycin (mTOR (show FRAP1 Proteins))- and adhesion kinase (FAK)-related pathways might offer a strategy for treating acute lymphoblastic leukemia (ALL).

  10. it was also observed that miR-7 (show LILRB1 Proteins) regulated the proliferation and migration of colon cancer by regulating the protein expression of FAK, therefore, regulating the expression of matrix metalloproteinase (MMP)-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins)

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  2. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  3. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  4. These data suggest an important role for the FERM domain in the activation of FAK.

  5. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Proteins), while phosphorylation at Y925 controls the rate of point contact turnover.

  6. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  7. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK promotes nascent integrin adhesions (NA) assembly and timely turnover to couple lamellipodial protrusion to adhesions for efficient advance of the leading edge. Phosphorylation on Y397 of FAK promotes dense NA formation but is dispensable for transient NA stabilization and leading edge advance.

  2. this manuscript shows that endothelial cell FAK activity induces VCAM-1 (show VCAM1 Proteins) expression and contributes to atherosclerosis

  3. FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.

  4. Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.

  5. results suggest that LPS (show TLR4 Proteins)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Proteins) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Proteins) on osteoblast performance

  6. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

  7. data indicate that PTPalpha (show PTPRA Proteins) and FAK, which are enriched in FAs (show FAS Proteins), interact with IP3R1 (show ITPR1 Proteins) at adjacent ER sites to spatially sequester IL-1 (show IL1A Proteins)-induced Ca(2 (show CA2 Proteins)+) signalling

  8. FAK-regulated signalling module PDK1 (show PDPK1 Proteins)-Akt (show AKT1 Proteins)-p70S6K (show RPS6KB1 Proteins) that controls Src's intracellular trafficking operates at Src (show SRC Proteins)-containing autophagosomes.

  9. Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.

  10. FAK deletion correlates with increased phosphorylation of Tks-5 (tyrosine kinase substrate with five SH3 domain) and reactive oxygen species production.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK activation in response to shear stress.

  2. XIAP (show XIAP Proteins) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C

  4. These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Proteins)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Proteins)-induced vascular smooth muscle cell migration.

FAK (PTK2) Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Gene names and symbols associated with PTK2

  • PTK2 protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (Ptk2)
  • protein tyrosine kinase 2 (ptk2)
  • PTK2 protein tyrosine kinase 2 (Ptk2)
  • Fadk protein
  • FAK protein
  • FAK1 protein
  • FRNK protein
  • mKIAA4203 protein
  • p125FAK protein
  • pp125FAK protein
  • PPP1R71 protein

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

GENE ID SPECIES
100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
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