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Catalyzes the transfer of phosphatidylcholine between membranes. Additionally we are shipping PCTP Antibodies (54) and PCTP Proteins (8) and many more products for this protein.
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Mutations in PCTP gene is associated with prostate cancer
PC-TP contributes to the racial difference in PAR4 (show PAWR ELISA Kits)-mediated platelet activation.
crystal structures of human PC-TP in complex with dilinoleoyl-PtdCho or palmitoyl-linoleoyl-PtdCho reveal that a single well-ordered PtdCho molecule occupies a centrally located tunnel
phosphatidylcholine transfer protein gene variants are associated with LDL-peak particle size
Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2 (show ACOT13 ELISA Kits)) and the homeodomain transcription factor Pax3 (paired box gene 3 (show PAX3 ELISA Kits)), respectively, as PC-TP-interacting proteins.
These observations suggest that PC-TP promotes liver injury by mediating the intermembrane transfer of phosphatidylcholines, thus stabilizing more pathogenic microvesicular lipid droplets.
Improved glucose tolerance in Pctp(-/-);ob/ob mice in the absence of increases in energy expenditure or core body temperature indicates a direct pathogenic role for Phosphatidylcholine transfer protein in diabetes in leptin (show LEP ELISA Kits) deficient mice
Them2 (show ACOT13 ELISA Kits) and phosphatidylcholine transfer protein regulate lipid and glucose metabolism
PC-TP-THEM2 (show ACOT13 ELISA Kits) complex reduces phosphorylation and stability of IRS2 (show IRS2 ELISA Kits) and increases stability of the TSC1 (show TSC1 ELISA Kits)-TSC2 (show TSC2 ELISA Kits) complex
Findings support a key role for Pctp in limiting mitochondrial oxidation of fatty acids and thus regulating adaptive thermogenesis in BAT (show BAAT ELISA Kits).
regulation of cholesterol homeostasis is a physiological function of PC-TP in liver, which can be overcome with a cholesterol-rich lithogenic diet
In Pctp(-/-) mice, there was an accumulation of small alpha-migrating HDL (show HSD11B1 ELISA Kits) particles. PC-TP participates in HDL (show HSD11B1 ELISA Kits) reverse cholesterol transport.
PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations
NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains.
Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.
START domain-containing protein 2
, StAR-related lipid transfer (START) domain containing 2
, stAR-related lipid transfer protein 2