anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) Antibodies

KCNA1 encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. Additionally we are shipping KCNA1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNA1 16485 P16388
KCNA1 24520 P10499
KCNA1 3736 Q09470
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Top anti-KCNA1 Antibodies at antibodies-online.com

Showing 10 out of 98 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissuereacted with KCNA1 Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of KCNA1 Antibody (Center) in Hela cell line lysates (35ug/lane). This demonstrates the KCNA1 antibody detected the KCNA1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB KCNA1 Antibody (Center) (ABIN658604) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the KCNA1 antibody detected the KCNA1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated ELISA, WB Western Blot (WB) analysis of specific cells using KV1.1 Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/MCF-7/HeLa cells, using KCNA1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IHC (fro), IF, IP, WB 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Anti-KCNA1 / Kv1.1 antibody IHC staining of human brain, cerebellum, purine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959338 concentration 5 ug/ml. 50 μL Log in to see 7 to 9 Days
$451.00
Details
Dog Rabbit Un-conjugated IP, WB Western blot analysis of Kv1.1 expression in HEK293 (A), MCF7 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details

KCNA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-KCNA1 Antibodies

  1. Dog (Canine) Polyclonal KCNA1 Primary Antibody for WB - ABIN2776084 : Tan, Lennon, Klein, Boeve, Pittock: Clinical spectrum of voltage-gated potassium channel autoimmunity. in Neurology 2008 (PubMed)

  2. Human Polyclonal KCNA1 Primary Antibody for IHC (p), WB - ABIN658604 : Kim, Niethammer, Rothschild, Jan, Sheng: Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. in Nature 1995 (PubMed)

  3. Human Polyclonal KCNA1 Primary Antibody for WB - ABIN265021 : Baumann, Grupe, Ackermann, Pongs: Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems. in The EMBO journal 1989 (PubMed)

  4. Human Polyclonal KCNA1 Primary Antibody for EIA, IHC (p) - ABIN952993 : Graves, Rajakulendran, Zuberi, Morris, Schorge, Hanna, Kullmann: Nongenetic factors influence severity of episodic ataxia type 1 in monozygotic twins. in Neurology 2010 (PubMed)

More Antibodies against KCNA1 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. we identify Kvbeta1.1 (show KCNAB1 Antibodies) as a sensor of pyridine nucleotide changes and as a modulator of Kv4.2 (show KCND2 Antibodies) gating, action potential duration, and ECG in the mouse heart.

  2. This study provide new insights into the dynamic and differential distribution of Kv1 (show KCNA5 Antibodies) channels and associated proteins during myelination.

  3. age-associated changes in Sphingolipid composition or CerS2 (show CERS2 Antibodies) ablation upregulate K(Ca) 1.1 and impair Ca(2 (show CA2 Antibodies)+) mobilization, which thereby induces contractile dysfunction of gastric smooth muscle.

  4. Kcna-1 null mice initially expressed only a few of the most severe seizure types that progressively increased in frequency and decreased in seizure severity

  5. Kv1.2 (show KCNA2 Antibodies) channels represent an important physiological link in electric field-induced cell migration.

  6. Spontaneous seizures in Kcna1-null mice activate Fos expression in select limbic circuits

  7. Data suggest that the behavioral effect of Kv1.1 (show KCNA2 Antibodies) deletion is primarily to impede binaural integration and thus to mimic monaural hearing.

  8. The Kv1.1 (show KCNA2 Antibodies) null mouse is a potential model for sudden unexpected death in epilepsy in patients

  9. Kv1.1 (show KCNA2 Antibodies) is modulated by ANK3 (show ANK3 Antibodies) in conditions of high dietary magnesium

  10. these data indicate that loss of Kv1.1 (show KCNA2 Antibodies) enhances synaptic release in the CA3 (show CA3 Antibodies) region, which reduces spike timing precision of individual neurons leading to disorganization of network oscillatory activity and promotes the emergence of fast ripples.

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1, KCNA2 (show KCNA2 Antibodies), and KCNV2 (show KCNV2 Antibodies) in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1, KCNA2 (show KCNA2 Antibodies), and KCNV2 (show KCNV2 Antibodies) genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.

  2. we demonstrate that the pathophysiological impact of the I262T mutation entails altered channel gating and defective protein biosynthesis, both of which raise imperative questions that call for further elucidation of the structural and functional roles of the S3 transmembrane segment in Kv1.1 channels.

  3. Herein, we critically evaluate the molecular and biophysical characteristics of the KV1.1 protein in comparison with others and discuss their role in the greater penetrance of KCNA1 mutations in humans leading to the neurological signs of episodic ataxia (show USP14 Antibodies) type 1

  4. KCNA1 mutations should be considered in patients of all ages with episodic neurological phenotypes, even when ataxia (show USP14 Antibodies) is not present.

  5. These findings provide evidence of an intrinsic cardiac role of Kv1.1 channels and indicate that they may contribute to atrial repolarization and atrial fibrillation susceptibility.

  6. Fine-tuning of Kv1.1 surface expression by RNA editing might contribute to the complexity of neuronal Kv channel regulation.

  7. Novel mutations in KCNA1 genes are associated with episodic ataxia (show USP14 Antibodies) type 1.

  8. Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.

  9. The combination of copy number variant and SNPs in KCNA1 (and SCN1A (show SCN1A Antibodies)) genes increased the risk for both epilepsy and premature death.

  10. New mutations (R167M, C185W and I407M) were identified in three out of the four families. When expressed in human embryonic kidney cells, all three new mutations resulted in a loss of K(v)1.1 (show KCNA2 Antibodies) channel function.

KCNA1 Antigen Profile

Protein Summary

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Gene names and symbols associated with KCNA1

  • potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) (KCNA1) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (KCNA1) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (LOC100037722) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (Kcna1) antibody
  • AEMK antibody
  • AI840627 antibody
  • EA1 antibody
  • HBK1 antibody
  • HUK1 antibody
  • Kca1-1 antibody
  • Kcna antibody
  • KCNA1 antibody
  • Kcpvd antibody
  • KV1.1 antibody
  • MBK1 antibody
  • mceph antibody
  • Mk-1 antibody
  • MK1 antibody
  • RBK1 antibody
  • Shak antibody

Protein level used designations for KCNA1

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) , voltage-gated potassium channel Kv1.1 , potassium voltage-gated channel, shaker-related subfamily, member 1 , voltage-gated potassium channel , potassium voltage-gated channel subfamily A member 1 , potassium voltage-gated channel subfamily A member 1-like , MKI , brain potassium channel protein-1 , megencephaly , potassium voltage gated channel, shaker related subfamily, member 1 , voltage-gated potassium channel subunit Kv1.1 , IA , RBKI , RCK1 , potassium (K+) channel protein voltage dependent , potassium voltage gated channel shaker related subfamily member 1 , voltage-gated K(+) channel HuKI , voltage-gated potassium channel HBK1

GENE ID SPECIES
428101 Gallus gallus
466928 Pan troglodytes
538703 Bos taurus
711630 Macaca mulatta
100037717 Oryctolagus cuniculus
100037722 Oryctolagus cuniculus
100051648 Equus caballus
100395602 Callithrix jacchus
100431422 Pongo abelii
100469172 Ailuropoda melanoleuca
16485 Mus musculus
24520 Rattus norvegicus
3736 Homo sapiens
486732 Canis lupus familiaris
100048962 Sus scrofa
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