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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Proteins (5) and many more products for this protein.
Showing 10 out of 68 products:
Human Polyclonal KCNA2 Primary Antibody for WB - ABIN265022
Stühmer, Ruppersberg, Schröter, Sakmann, Stocker, Giese, Perschke, Baumann, Pongs: Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. in The EMBO journal 1989
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Rat (Rattus) Polyclonal KCNA2 Primary Antibody for IHC, WB - ABIN350378
Kim, Niethammer, Rothschild, Jan, Sheng: Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. in Nature 1995
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Human Polyclonal KCNA2 Primary Antibody for EIA, IHC (p) - ABIN952994
Denning, Crozier, Sachs, Woolf: From the gating charge response to pore domain movement: initial motions of Kv1.2 dynamics under physiological voltage changes. in Molecular membrane biology 2009
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Cow (Bovine) Polyclonal KCNA2 Primary Antibody for ICC, IF - ABIN449234
Joseph, Thakali, Pathan, Kang, Rusch, Rhee: Postsynaptic density-95 scaffolding of Shaker-type K? channels in smooth muscle cells regulates the diameter of cerebral arteries. in The Journal of physiology 2011
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Cow (Bovine) Polyclonal KCNA2 Primary Antibody for BP, IP - ABIN452088
Zhou, Ma, Huang: Specific antibodies to the external vestibule of voltage-gated potassium channels block current. in The Journal of general physiology 1998
Human Polyclonal KCNA2 Primary Antibody for IHC (p), WB - ABIN658605
Stirling, Williams, Morielli: Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel. in Molecular biology of the cell 2009
Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1 (show KCNA1 Antibodies), KCNA2, and KCNV2 (show KCNV2 Antibodies) in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1 (show KCNA1 Antibodies), KCNA2, and KCNV2 (show KCNV2 Antibodies) genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.
In the asymptomatic mother, the mutated copy of the CDKL5 (show CDKL5 Antibodies) gene was inactivated in 90% of blood cells. We also identified a premature stop codon (p.Arg926*) in IQSEC2 (show IQSEC2 Antibodies) in a patient with a Rett-like phenotype. Finally, exome sequencing enabled us to characterize a heterozygous de novo missense (p.Val408Ala) in KCNA2 in a girl with infantile-onset seizures variant of Rett syndrome (RTT)
Novel recurrent missense mutation within the Kv1.2 voltage sensor associated with variable phenotypes, including hereditary spastic paraplegia, ataxia (show USP14 Antibodies), and intellectual disability.
This study demonstrated that KCNA2 mutation causes episodic ataxia (show USP14 Antibodies) and pharmacoresponsive epilepsy.
Use-dependent activation of Kv1.2 channels is mediated by an extrinsic regulator that binds preferentially to the channel closed state, with Thr252 being necessary but not sufficient for this interaction to alter channel function.
This gene has not been previously described as a cause of disease in humans, but mutations of the orthologous gene in mice (Kcna2) are known to cause both ataxia (show USP14 Antibodies) and convulsions
KCNA2 is a new gene involved in human neurodevelopmental disorders through two different mechanisms, predicting either hyperexcitability or electrical silencing of KV1.2-expressing neurons.
the inhibition of two K(+) channel (show KCNC4 Antibodies) isoforms, Kv1.2 and KCa3.1 (show KCNN4 Antibodies), by two drug molecules, lidocaine and TRAM (show TRAM1 Antibodies)-34, is examined in atomic detail using molecular dynamics simulations.
isoform betaII plays a central role in the PKC (show PRRT2 Antibodies)-dependent regulation of Kv1.5 (show KCNA5 Antibodies)/Kvbeta1.2 channels.
Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.
Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 (show CA3 Antibodies) pyramidal cells
analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics
This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines.
Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38 (show CRK Antibodies)/Mk2 is involved in this inflammatory response.
The dynamic Sig-1R (show SIGMAR1 Antibodies)-Kv1.2 complex represents a mechanism that shapes neuronal and behavioral response to cocaine.
Overlapping patterns with differential expression and precise localization of Kv1.1 and Kv1.2 channels targeted to specialized subcellular compartments contribute to distinctive patterns of neuronal excitability --REVIEW
the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated.
These results suggest that independent of known mutations in Kcna1 (show KCNA1 Antibodies) encoding Kv1.1, Kcna2 mutations may be important molecular correlates underlying human cerebellar ataxic disease.
Data show that PSD-95 (show DLG4 Antibodies) colocalizes precisely with Kv1 (show KCNA5 Antibodies) potassium channels and Caspr2 (show CNTNAP2 Antibodies) at juxtaparanodes, and that a macromolecular complex of Kv1 (show KCNA5 Antibodies) channels and PSD-95 (show DLG4 Antibodies) can be immunopurified from mammalian brain and spinal cord.
Kcna2-null mice exhibited increased seizure susceptibility but, in contrast to Kcna1 (show KCNA1 Antibodies)-null mice, hypoexcitability and enlarged Kv1 (show KCNA5 Antibodies) currents in auditory neurons.
When mapped onto the X-ray structure of the K(v)1.2 channel the large number of permissive mutations support the notion of relatively independent domains, consistent with crystallographic studies
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
potassium voltage-gated channel, shaker-related subfamily, member 2
, potassium voltage-gated channel subfamily A member 2-like
, potassium voltage-gated channel subfamily A member 2
, voltage-gated potassium channel Kv1.2
, shaker subfamily potassium channel Kv1.2 alpha subunit
, voltage-gated K(+) channel HuKIV
, voltage-gated potassium channel HBK5
, voltage-gated potassium channel protein Kv1.2
, voltage-gated potassium channel subunit Kv1.2
, Potassium (K+) channel protein alpha 2, voltage dependent
, potassium voltage gated channel shaker related subfamily member 2
, Kv1.2' potassium channel
, Voltage-gated potassium channel subunit Kv1.2
, potassium voltage-gated channel, shaker-related subfamily, member 2 a
, delayed rectifier K+ channel
, voltage-dependent K channel
, voltage-gated channel, shaker-related subfamily, member 2
, potassium channel (BGK5)