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PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Additionally we are shipping PCSK9 Antibodies (160) and PCSK9 Proteins (64) and many more products for this protein.
Showing 10 out of 77 products:
Human PCSK9 ELISA Kit for Sandwich ELISA - ABIN2345049
Jin, Park, Kim, Vaziri: Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2014
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Mouse (Murine) PCSK9 ELISA Kit for Sandwich ELISA - ABIN2685159
Seidah, Benjannet, Wickham, Marcinkiewicz, Jasmin, Stifani, Basak, Prat, Chretien: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Human PCSK9 ELISA Kit for Sandwich ELISA - ABIN820112
Dogan, Akman, Simsek, Ozdem, Comak, Gokceoglu, Kardelen, Koyun: Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease. in Renal failure 2015
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These studies provide a definitive characterization of the composition and activity of the truncated form of PCSK9 found in human serum
PCSK9 loss-of-function variants were associated with a pooled odds ratio for coronary heart disease of 0.51 in blacks and 0.82 in whites.
Mature PCSK9 associated with atheroma volume and impaired vessel remodeling in HeFH patients with coronary artery disease
Despite having lower LDL-C, circulating PCSK9 levels were increased in patients coinfected with HIV and HCV in parallel with elevations in the inflammatory, proatherogenic cytokine interleukin-6 (show IL6 ELISA Kits).
Circulating PCSK9 is associated with New-onset diabetes after transplantation (NODAT) in renal transplant recipients. The PCSK9 pathway may contribute to the pathogenesis of NODAT.
PCSK9 inhibits hepatitis C virus replication through interacting with NS5A.
PCSK9 levels were significantly higher in patients with peripheral artery disease (PAD), especially those with advanced PAD.
In statin treated asymptomatic familial hypercholesterolemia patients, elevated PCSK9 and Lp(a (show APOA ELISA Kits)) levels are independently associated with the presence and severity of coronary artery calcification, a good predictor of coronary artery disease
PCSK9 has a role in cardiovascular health; PCSK9 levels are modestly but significantly associated with increased risk of total CV events [review and meta-analysis]
LY3015014 is a humanized immunoglobulin G4 (IgG4) monoclonal antibody that binds to the catalytic domain of PCSK9.
PCSK9, by sustaining smooth muscle cell synthetic phenotype, proliferation, and migration, may play a pro-atherogenic role in the arterial wall
PCSK9 inhibits lipoprotein(a) clearance through the LDLR (show LDLR ELISA Kits).
Use Crispr-Cas (show CTNND1 ELISA Kits) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.
Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.
These observations suggest positive feedback interplay between SMC (show DYM ELISA Kits)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.
AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (show APOE ELISA Kits)(-/-) mice.
Adeno (show ADORA2A ELISA Kits)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.
conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (show CA2 ELISA Kits)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (show LDLR ELISA Kits) degradation and promoting LDLR (show LDLR ELISA Kits)-dependent hepatic cholesterol uptake.
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor (show LDLR ELISA Kits) Degradation.
PCSK9 increases hepatic lipid and lipoprotein production via apoE (show APOE ELISA Kits)- and LDLR (show LDLR ELISA Kits)-dependent mechanisms
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
proprotein convertase subtilisin/kexin type 9
, convertase subtilisin/kexin type 9 preproprotein
, neural apoptosis regulated convertase 1
, subtilisin/kexin-like protease PC9
, convertase subtilisin
, neural apoptosis-regulated convertase 1
, proprotein convertase 9
, proprotein convertase PC9
, proprotein convertase subtilisin/kexin type 9 preproprotein
, Proprotein convertase 9
, Subtilisin/kexin-like protease PC9