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Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 Proteins (P2RX7)

The product of P2RX7 belongs to the family of purinoceptors for ATP. Additionally we are shipping P2RX7 Antibodies (119) and P2RX7 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
P2RX7 5027 Q99572
P2RX7 18439 Q9Z1M0
Rat P2RX7 P2RX7 29665 Q64663
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Top P2RX7 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$362.88
Details

P2RX7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) Interaction Partners

Zebrafish Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. Blockade of the P2X7 receptor reduces cyst formation via ERK (show MAPK1 Proteins)-dependent pathways in a zebrafish model of polycystic kidney disease.

Human Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. there is a relationship between the elevated expression of P2X3 (show P2RX3 Proteins) receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.

  2. a pivotal role of P2X7 receptor-pannexin-1 (show PANX1 Proteins) in oxysterols toxicity in retinal cells

  3. significant upregulation of P2X7R and increased IL-1beta (show IL1B Proteins) release seems to be a particular phenomenon in patients with neuropathic pain

  4. We identified potential nuclear and membrane biomarkers (increased expression of ZO-1 (show TJP1 Proteins), caveolin-1 (show CAV1 Proteins) and P2X7 receptor) of risks for placenta and pregnancy

  5. The association between independent P2X7R polymorphisms with stress fracture prevalence supports the role of a genetic predisposition in the development of stress fracture

  6. these data indicate that activation of EGFR (show EGFR Proteins) enhanced the expression of P2X7R in neuroblastoma (show ARHGEF16 Proteins) cells lacking trophic support, being PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/PKC (show PRRT2 Proteins) signaling pathway and Sp1 (show PSG1 Proteins) mediating this pro-survival outcome

  7. Result suggest the positive correlation between purinergic receptor P2X 7 (P2X7R) and T-complex protein 1 (TCP-1) in lymphoma patients.

  8. A gain-of-function mutation in P2X7R associated with autoimmune disease caused enhanced TG2 (show TGM2 Proteins) externalization from cells, and this correlated with increased pore activity.

  9. pancreatic ductal adenocarcinoma cell lines overexpress P2X7R and the receptor plays crucial roles in cell survival, migration and invasion.

  10. P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis.

Cow (Bovine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. For the inflammasome-dependent IL-1beta (show IL1B Proteins) release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta (show IL1B Proteins) release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.

Mouse (Murine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. P2X7R stimulation in macrophages is able to release potent anti-inflammatory proteins, such as Annexin A1 (show ANXA1 Proteins), independently of their polarization state suggesting for first time a potential role for P2X7R during resolution of the inflammation and not linked to the release of pro-inflammatory cytokines.

  2. These results indicate that activation of Panx1 (show PANX1 Proteins) and P2X7 R are required for apoptotic osteocytes in fatigued bone to trigger RANKL (show TNFSF11 Proteins) production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.

  3. A role for post-transcriptional regulation of the P2X7R in epilepsy

  4. We also demonstrate extracellular ATP participates in regulation of inflammatory responses of colitis, through P2 x 7 receptor and inflammasome and NFkappaB signaling.

  5. we reveal that neuronal vulnerability to ATP depends on the expression level of P2X7R

  6. Activation of P2X7 by ATP induced the release of TNFalpha (show TNF Proteins) from microglia which protected neurons from NMDA-induced excitotoxicity, might also account for neuroprotective properties of valproic acid

  7. Data provide mechanistic insights into the role of KHG26792 in the inhibition of TNF-alpha (show TNF Proteins) produced via purinergic receptor P2X7 receptor-mediated activation of NFAT (show NFATC1 Proteins) and MAPK (show MAPK1 Proteins) pathways in adenosine triphosphate-treated BV-2 cells.

  8. Results suggest that P2X7R is an important activator of the immune response that leads to type 1 diabetes.

  9. P2X7R plays a role in the neuroinflammation in a model of mania.

  10. Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (P2X7R) and plays a role in lymphoid neoplasm metastasis.

P2RX7 Protein Profile

Protein Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Gene names and symbols associated with P2RX7

  • purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7)
  • purinergic receptor P2X, ligand-gated ion channel, 7 (p2rx7)
  • purinergic receptor P2X, ligand-gated ion channel, 7 (P2rx7)
  • AI467586 protein
  • P2RX7 protein
  • P2X(7) protein
  • p2x7 protein
  • P2X7R protein
  • p2xr7 protein

Protein level used designations for P2RX7

P2X purinoceptor 7 , purinergic receptor P2X, ligand-gated ion channel, 7 , p2X purinoceptor 7-like , ATP receptor , P2X7 receptor , P2Z receptor , purinergic receptor P2X7 variant A , P2X7 purinoceptor , purinergic receptor P2X7

GENE ID SPECIES
100058464 Equus caballus
387298 Danio rerio
452318 Pan troglodytes
699455 Macaca mulatta
771952 Gallus gallus
100458463 Pongo abelii
100588362 Nomascus leucogenys
5027 Homo sapiens
448778 Canis lupus familiaris
286814 Bos taurus
18439 Mus musculus
29665 Rattus norvegicus
497623 Sus scrofa
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