You are viewing an incomplete version of our website. Please click to reload the website as full version.

Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 Proteins (P2RX7)

The product of P2RX7 belongs to the family of purinoceptors for ATP. Additionally we are shipping P2RX7 Antibodies (95) and P2RX7 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
P2RX7 5027 Q99572
P2RX7 18439 Q9Z1M0
Rat P2RX7 P2RX7 29665 Q64663
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top P2RX7 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$362.88
Details

P2RX7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) Interaction Partners

Zebrafish Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. Blockade of the P2X7 receptor reduces cyst formation via ERK (show MAPK1 Proteins)-dependent pathways in a zebrafish model of polycystic kidney disease.

Human Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. these data indicate that activation of EGFR (show EGFR Proteins) enhanced the expression of P2X7R in neuroblastoma (show ARHGEF16 Proteins) cells lacking trophic support, being PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/PKC (show PRRT2 Proteins) signaling pathway and Sp1 (show PSG1 Proteins) mediating this pro-survival outcome

  2. Result suggest the positive correlation between purinergic receptor P2X 7 (P2X7R) and T-complex protein 1 (TCP-1) in lymphoma patients.

  3. A gain-of-function mutation in P2X7R associated with autoimmune disease caused enhanced TG2 (show TGM2 Proteins) externalization from cells, and this correlated with increased pore activity.

  4. pancreatic ductal adenocarcinoma cell lines overexpress P2X7R and the receptor plays crucial roles in cell survival, migration and invasion.

  5. P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis.

  6. Report association between elevated expression of P2X7 receptor in monocytes and high serum CRP (show CRP Proteins) and cytokine levels in type 2 diabetics.

  7. The altered function and expression of P2X7 and ART1 (show ART1 Proteins) in the human CD39 (show ENTPD1 Proteins)+ Treg or CD39 (show ENTPD1 Proteins)- Treg cells could participate in the resistance against cell death induced by ATP or NAD.

  8. signaling through purinergic receptors, particularly P2X7R, drives an adaptive Th17 response in human visceral adipose tissue underlying the metabolic changes in obesity.

  9. This chapter describes structural features of P2X7, chemical properties of its agonist, antagonist, and allosteric modulators and summarizes recent advances on P2X7 receptor as therapeutic target in the aforementioned diseases

  10. High P2X7R expression is a good prognostic factor for glioma radiosensitivity and survival probability in humans.

Cow (Bovine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. For the inflammasome-dependent IL-1beta (show IL1B Proteins) release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta (show IL1B Proteins) release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.

Mouse (Murine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. Activation of P2X7 by ATP induced the release of TNFalpha (show TNF Proteins) from microglia which protected neurons from NMDA-induced excitotoxicity, might also account for neuroprotective properties of valproic acid

  2. Data provide mechanistic insights into the role of KHG26792 in the inhibition of TNF-alpha (show TNF Proteins) produced via purinergic receptor P2X7 receptor-mediated activation of NFAT (show NFATC1 Proteins) and MAPK (show MAPK1 Proteins) pathways in adenosine triphosphate-treated BV-2 cells.

  3. Results suggest that P2X7R is an important activator of the immune response that leads to type 1 diabetes.

  4. P2X7R plays a role in the neuroinflammation in a model of mania.

  5. Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (P2X7R) and plays a role in lymphoid neoplasm metastasis.

  6. IL-17 (show IL17A Proteins) production in the hearts of M2AChR mice is dependent on P2x7 expression in dilated cardiomyopathy.

  7. unveiled the critical role of adenosine triphosphate-P2X7 receptor (ATP-P2X7R)in brain damage in radiation-induced brain injury (RBI), suggesting that inhibition of ATP-P2X7R axis might be a potential strategy for the treatment of patients with RBI.

  8. High P2X7R expression is a good prognostic factor for glioma radiosensitivity and survival probability.

  9. P2X7 is a protective factor and therapeutic target for the amelioration of hyperoxia-induced lung injury.

  10. Neutrophils express functional cell-surface P2X7R, which leads to ATP-induced loss of intracellular K(+), NLRP3 (show NLRP3 Proteins) inflammasome activation and IL-1beta (show IL1B Proteins) secretion.

P2RX7 Protein Profile

Protein Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Gene names and symbols associated with P2RX7

  • purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7)
  • purinergic receptor P2X, ligand-gated ion channel, 7 (p2rx7)
  • purinergic receptor P2X, ligand-gated ion channel, 7 (P2rx7)
  • AI467586 protein
  • P2RX7 protein
  • P2X(7) protein
  • p2x7 protein
  • P2X7R protein
  • p2xr7 protein

Protein level used designations for P2RX7

P2X purinoceptor 7 , purinergic receptor P2X, ligand-gated ion channel, 7 , p2X purinoceptor 7-like , ATP receptor , P2X7 receptor , P2Z receptor , purinergic receptor P2X7 variant A , P2X7 purinoceptor , purinergic receptor P2X7

GENE ID SPECIES
100058464 Equus caballus
387298 Danio rerio
452318 Pan troglodytes
699455 Macaca mulatta
771952 Gallus gallus
100458463 Pongo abelii
100588362 Nomascus leucogenys
5027 Homo sapiens
448778 Canis lupus familiaris
286814 Bos taurus
18439 Mus musculus
29665 Rattus norvegicus
497623 Sus scrofa
Selected quality suppliers for P2RX7 Proteins (P2RX7)
Did you look for something else?