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The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010].. Additionally we are shipping RAP1GDS1 Antibodies (54) and RAP1GDS1 Kits (6) and many more products for this protein.
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Data suggest that SmgGDS-558 splice variant exhibits a fold containing tandem copies of armadillo (show PKP1 Proteins)-repeat motifs not present in other guanine nucleotide exchange factors (GEFs); SmgGDS harbors distinct positively and negatively charged regions, both of which play critical roles in binding to RhoA (show RHOA Proteins) and in GEF (show SLC2A4RG Proteins) activity. (SmgGDS = smg (show SNRPG Proteins) p21 (show CDKN1A Proteins) stimulatory GDP exchange protein; RhoA (show RHOA Proteins) = ras homolog gene family, member A (show CXCL14 Proteins))
Unlike Rap1B (show RAP1B Proteins), phosphorylation in the polybasic region of Rap1A (show RAP1A Proteins) does not detectably inhibit its prenylation or its binding to SmgGDS-607.
In addition, a PINK1 (show PINK1 Proteins) mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1, played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF (show SLC2A4RG Proteins) member.
results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 (show AKT1 Proteins) pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins
DiRas1 (show DIRAS1 Proteins) expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS
SmgGDS promotes cell cycle progression in multiple types of cancer, making SmgGDS a valuable target for cancer therapeutics.
TG2 (show TGM2 Proteins) contributes to apoptosis induction in Jurkat T cells by modulating Ca2 (show CA2 Proteins)+ homeostasis via cross-linking RAP1GDS1.
findings identify SmgGDS-558 as an activator of RhoA (show RHOA Proteins) and NF-kB in breast cancer, and demonstrate a functional role for SmgGDS-558 in the proliferation of breast cancer cells and tumorigenesis.
this study provides evidence that SmgGDS-607 associates with GTPases through recognition of the last amino acid in the CAAX motif.
These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
These results identify SmgGDS as a novel regulator of myosin organization and contraction in vascular smooth muscle cells.
The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993
rap1 GTPase-GDP dissociation stimulator 1
, RAP1, GTP-GDP dissociation stimulator 1
, SMG GDS protein
, SMG P21 stimulatory GDP/GTP exchange protein
, exchange factor smgGDS
, ralB-binding protein A
, rap1 GTPase-GDP dissociation stimulator 1-A