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anti-Ryanodine Receptor 2 (Cardiac) (RYR2) Antibodies

RYR2 encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. Additionally we are shipping RYR2 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RYR2 6262 Q92736
RYR2 689560 B0LPN4
RYR2 20191 E9Q401
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Top anti-RYR2 Antibodies at antibodies-online.com

Showing 10 out of 36 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using RyR2 (Phospho-Ser2808) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RyR2 (Ab-2808) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Ryanodine Receptor 2 (pS2808) staining in U251 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Ryanodine Receptor 2 (pS2808) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$575.00
Details
Human Rabbit Un-conjugated IF, IHC (p) Immunohistochemistry analyzes of RyR2 antibody in paraffin-embedded human brain tissue. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$448.47
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$527.15
Details
Human Rabbit Un-conjugated IF, IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated IF, IHC   100 μL Log in to see 8 to 10 Days
$522.50
Details
Mouse Rabbit Un-conjugated WB 200 μL Log in to see 9 Days
$588.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC 100 μL Log in to see 14 Days
$201.19
Details

RYR2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,


Rat (Rattus) , , ,


Mouse (Murine) , , ,


More Antibodies against RYR2 Interaction Partners

Rabbit Ryanodine Receptor 2 (Cardiac) (RYR2) interaction partners

  1. Two regions of the ryanodine receptor (show RYR3 Antibodies) calcium channel are involved in Ca(2 (show CA2 Antibodies)+)-dependent inactivation

  2. [REVIEW] The efficacy of divalent calcium ion (Ca2 (show CA2 Antibodies)+) release in the myocardium depends on the amount of Ca2 (show CA2 Antibodies)+ loaded into the Ca2 (show CA2 Antibodies)+ store and the way in which this Ca2 (show CA2 Antibodies)* load influences the activity of the ryanodine receptor (show RYR3 Antibodies) Ca2+ release channel (RyR2).

  3. There were substantial transmural gradients in Cav1.2 (show CACNA1C Antibodies), KChIP2 (show KCNIP2 Antibodies), ERG (show KCNH2 Antibodies), KvLQT1 (show KCNQ1 Antibodies), Kir2.1 (show KCNJ2 Antibodies), NCX1 (show SLC8A1 Antibodies), SERCA2a (show ATP2A2 Antibodies) and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.

  4. phosphorylation and K201 acted similarly to change the conformation of RyR1 (show RYR1 Antibodies)/2 and regulate FKBP12 (show FKBP1A Antibodies)/12.6 binding.

Human Ryanodine Receptor 2 (Cardiac) (RYR2) interaction partners

  1. Studies indicate that the ryanodine receptors (RyRs: RyR1 (show RYR1 Antibodies), RyR2, RyR3 (show RYR3 Antibodies)) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1 (show ITPR1 Antibodies), IP3R2 (show ITPR2 Antibodies), IP3R3 (show ITPR3 Antibodies)) are the major Ca(2 (show CA2 Antibodies)+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).

  2. although the EF-hand domain is not required for RyR2 activation by cytosolic Ca(2 (show CA2 Antibodies)+), it plays an important role in luminal Ca(2 (show CA2 Antibodies)+) activation and SOICR

  3. Half of the RYR2 mutations in catecholaminergic polymorphic ventricular tachycardia cohort were de novo, and most of the remaining mutations were inherited from mothers.

  4. A deletion of exon 3 of the RYR2 gene was found in a family with catecholaminergic polymorphic ventricular tachycardia.

  5. G357S_RyR2 mutation in the cardiac ryanodine receptor was identified in 179 family members with Catecholaminergic polymorphic ventricular tachycardia and in 6 Sudden cardiac death cases.

  6. We propose a mechanism in which RYR2 sequence variants result in aberrant stress-induced calcium release into the mitochondria of autonomic neurons, resulting in an increased risk to develop autonomic/functional disease such as cyclic vomiting syndrome.

  7. Our study identifies a significant role of RyR2 rs3766871 minor allele for increased susceptibility to VT/VF in a population of implanted with a cardioverter defibrillator patients with heart failure.

  8. unlike RyR1 (show RYR1 Antibodies) normal WT RyR2 does not bind dantrolene in spite of the fact that the RyR1 (show RYR1 Antibodies) dantrolene-binding site (residues 590-609) is conserved in RyR2

  9. How phosphorylation of RyR (show RYR1 Antibodies) affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 (show FKBP1A Antibodies) and FKBP12.6 (show FKBP1B Antibodies)) are involved in heart failure

  10. induced Pluripotent Stem Cell-derived cardiomyocytes are useful for investigating the similarities/differences in the pathophysiological consequences of RyR2 versus CASQ2 (show CASQ2 Antibodies) mutations underlying Catecholaminergic polymorphic ventricular tachycardia.

Mouse (Murine) Ryanodine Receptor 2 (Cardiac) (RYR2) interaction partners

  1. Inhibition of RyR2 phosphorylation can suppress sarcoplasmic reticulum Ca(2 (show CA2 Antibodies)+) leak in mdx (show DMD Antibodies) mouse hearts in part by reducing RyR2 oxidation.

  2. Interacting network of the gap junction protein connexin43 (show GJA1 Antibodies), which includes Ryr2 and Cox1 (show COX1 Antibodies), is modulated by ischemia and reperfusion in the heart.

  3. While CASQ2 (show CASQ2 Antibodies) stabilizes RyR2 rendering it refractory in the diastolic phase, HRC (show HRC Antibodies) enhances RyR2 activity facilitating RyR2 recovery from refractoriness.

  4. These results provide no evidence that the H29D mutation enhances the cytosolic Ca2 (show CA2 Antibodies)+ activation of RyR2.

  5. CaMK2d (show CAMK2B Antibodies)-dependent phosphorylation of RyR2-S2814 is significant in cardiomyopathy, independent of hypertrophy, induced by prolonged beta-adrenergic receptor stimulation.

  6. RyR2 activity determines the potency of open-state blockers flecainide and R-propafenone for suppressing arrhythmogenic Ca2 (show CA2 Antibodies)+ waves in cardiomyocytes.

  7. Flecainide (1 mum) rescues the RyR2-P2328S atrial arrhythmogenic phenotype by restoring compromised INa (show INA Antibodies) and lambda, changes recently attributed to increased sarcoplasmic reticular Ca(2 (show CA2 Antibodies)+) release.

  8. The data suggest that the uneven distribution of dyads or calcium release sites within the cells resulting from an overall reduction in RyR2 content may contribute to the poor cardiac performance and early death of Ryr2 (ADA/ADA (show ADA Antibodies)) mice

  9. Data indicate that leaky ryanodine receptor 2 cardiac calcium release channel RyR2 cause mitochondrial Ca2 (show CA2 Antibodies)+ overload and dysfunction in heart failure (HF).

  10. Simultaneous detection of GFP-RyR2 clusters and Ca(2 (show CA2 Antibodies)+) sparks showed that Ca(2 (show CA2 Antibodies)+) sparks originated exclusively from RyR2 clusters. Ca(2 (show CA2 Antibodies)+) sparks from RyR2 clusters induced no detectable changes in mitochondrial Ca(2 (show CA2 Antibodies)+) level

RYR2 Antigen Profile

Protein Summary

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

Gene names and symbols associated with RYR2

  • ryanodine receptor 2 (cardiac) (RYR2) antibody
  • ryanodine receptor 2-like (LOC537376) antibody
  • cardiac ryanodine receptor (RYR-2) antibody
  • ryanodine receptor 2 (cardiac) (Ryr2) antibody
  • ryanodine receptor 2, cardiac (Ryr2) antibody
  • 9330127I20Rik antibody
  • ARVC2 antibody
  • ARVD2 antibody
  • RyR antibody
  • RYR-2 antibody
  • RYR2 antibody
  • VTSIP antibody

Protein level used designations for RYR2

cardiac muscle ryanodine receptor , ryanodine receptor 2 (cardiac) , ryanodine receptor 2-like , Ca2+ release channel , cardiac muscle ryanodine receptor-calcium release channel , cardiac muscle-type ryanodine receptor , ryanodine receptor 2 , type 2 ryanodine receptor , cardiac ryanodine receptor 2 , cardiac-type ryanodine receptor , islet-type ryanodine receptor , kidney-type ryanodine receptor , ryanodine receptor type II , calcium release channel , ryanodine receptor type 2

GENE ID SPECIES
457846 Pan troglodytes
100028207 Monodelphis domestica
100057437 Equus caballus
100406916 Callithrix jacchus
537376 Bos taurus
100009536 Oryctolagus cuniculus
403615 Canis lupus familiaris
100731307 Cavia porcellus
6262 Homo sapiens
689560 Rattus norvegicus
20191 Mus musculus
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