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SH3 and Multiple Ankyrin Repeat Domains 2 Proteins (SHANK2)

SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Additionally we are shipping SHANK2 Antibodies (136) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SHANK2 22941 Q9UPX8
Rat SHANK2 SHANK2 171093 Q9QX74
SHANK2 210274 Q80Z38
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Top SHANK2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SHANK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Interaction Partners

Human SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. variants in the SHANK2 gene in a schizophrenia patient cohort

  2. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR (show CFTR Proteins).

  3. syndapin I (show PACSIN1 Proteins) functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2.

  4. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.

  5. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate receptors at the synapse and increased levels of ProSAP2/Shank3

  6. we confirmed that de novo SHANK2 deletions are present in patients with ASD (show ARSD Proteins) and showed that several SHANK2 variants reduce the number of synapses in vitro

  7. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD (show ARSD Proteins)

  8. we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD (show ARSD Proteins)) and mental retardation

  9. betaPix (show ARHGEF7 Proteins) up-regulates NHE3 (show SLC9A3 Proteins) membrane expression and activity by Shank2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells

  10. Shank2 increased the membrane expression and basal activity of NHE3 (show SLC9A3 Proteins) and attenuated the cAMP-dependent inhibition of NHE3 (show SLC9A3 Proteins) activity.

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1 (show TBR1 Proteins)+/- mice

  2. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW}

  3. Shank2 appears to be a key molecule regulating epithelial fluid secretion.

  4. syndapin I (show PACSIN1 Proteins) functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2.

  5. Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses.

  6. Shank2 negatively regulates CFTR (show CFTR Proteins) and this may play a significant role in maintaining epithelial homeostasis

  7. Data suggest that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina.

SHANK2 Protein Profile

Protein Summary

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Gene names and symbols associated with SHANK2

  • SH3 and multiple ankyrin repeat domains 2 (SHANK2)
  • SH3/ankyrin domain gene 2 (shank2)
  • SH3 and multiple ankyrin repeat domains 2 (LOC100338286)
  • SH3 and multiple ankyrin repeat domains 2 (Shank2)
  • SH3 and multiple ankyrin repeat domains 2 (shank2)
  • SH3/ankyrin domain gene 2 (Shank2)
  • auts17 protein
  • cortbp1 protein
  • cttnbp1 protein
  • MGC122482 protein
  • mKIAA1022 protein
  • prosap1 protein
  • SHANK protein
  • SHANK2 protein
  • spank-3 protein

Protein level used designations for SHANK2

SH3 and multiple ankyrin repeat domains 2 , SH3 and multiple ankyrin repeat domains protein 2-like , GKAP/SAPAP interacting protein , SH3 and multiple ankyrin repeat domains protein 2 , cortactin SH3 domain-binding protein , cortactin-binding protein 1 , proline-rich synapse associated protein 1 , proline-rich synapse-associated protein 1 , GKAP/SAPAP-interacting protein , SH3/ankyrin domain gene 2 , proline rich synapse associated protein 1 , cortBP1

GENE ID SPECIES
428858 Gallus gallus
100124731 Xenopus (Silurana) tropicalis
100338286 Oryctolagus cuniculus
100412179 Callithrix jacchus
466694 Pan troglodytes
708192 Macaca mulatta
747845 Pan troglodytes
100031879 Monodelphis domestica
100438523 Pongo abelii
100579795 Nomascus leucogenys
22941 Homo sapiens
171093 Rattus norvegicus
483677 Canis lupus familiaris
618649 Bos taurus
734458 Xenopus laevis
210274 Mus musculus
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