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Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Additionally we are shipping SIK2 Proteins (10) and SIK2 Kits (8) and many more products for this protein.
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Human Monoclonal SIK2 Primary Antibody for FACS - ABIN2666364
Horike, Takemori, Katoh, Doi, Min, Asano, Sun, Yamamoto, Kasayama, Muraoka, Nonaka, Okamoto: Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. in The Journal of biological chemistry 2003
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Human Polyclonal SIK2 Primary Antibody for IP, WB - ABIN4354919
Küser-Abali, Ozcan, Ugurlu, Uysal, Fuss, Bugra-Bilge: SIK2 is involved in the negative modulation of insulin-dependent muller cell survival and implicated in hyperglycemia-induced cell death. in Investigative ophthalmology & visual science 2013
Data, including data from studies conducted with knockout mice, suggest that Pin1 (show PIN1 Antibodies) (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 (show PIN1 Antibodies) appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (show INS Antibodies); Pin1 (show PIN1 Antibodies) interacts with Sik2 (salt-inducible kinase 2) to regulate calcium signaling.
The data highlight an integral role for SIK2 and SIK3 in innate immunity by preventing the differentiation of macrophages into a potent and stable anti-inflammatory phenotype.
SIK2 acts directly on CRTC2 (show CRTC2 Antibodies), CRTC3 (show CRTC3 Antibodies) and HDAC4 (show HDAC5 Antibodies), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (show CREB1 Antibodies)-regulated transcription co-activators and PP2A (show PPP2R2B Antibodies). Downstream, SIK2 increases GLUT4 (show SLC2A4 Antibodies) levels and glucose uptake in adipocytes.
Sik1 (show SIK1 Antibodies), Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 Antibodies) in the liver.
Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (show CRTC2 Antibodies)-CREB (show CREB1 Antibodies) function of the white adipocytes.
The SIK2-p35 (show CDK5R1 Antibodies)-PJA2 (show PJA2 Antibodies) complex is essential for glucose homeostasis and provides a link between p35 (show CDK5R1 Antibodies)-CDK5 (show CDK5 Antibodies) and the AMPK (show PRKAA1 Antibodies) family in excitable cells.
tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (show CAMK2G Antibodies) I/IV, and regulates CREB (show CREB1 Antibodies) via TORC1 (show CRTC1 Antibodies).
SIK2 represses eumelanogenesis in mice.
low SIK2 activity was associated with increased p300 HAT (show EP300 Antibodies) activity, ChREBP (show MLXIPL Antibodies) hyperacetylation, and hepatic steatosis
Activated SIK2 plays a dual role in augmenting AMPK (show PRKAA1 Antibodies)-induced phosphorylation of acetyl-CoA carboxylase and in activating the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway through p85alpha-S154 phosphorylation. These findings identify SIK2 at the apex (show APEX1 Antibodies) of the adipocyte-induced signaling cascades in cancer cells.
Findings suggest that SIK2 restricts autophagic flux which in the claudin-low subtype is essential for viability of triple-negative breast cancer cells.
Data show that microRNA miR (show MLXIP Antibodies)-203 and the salt-inducible kinase 2 (SIK2) are reverse expressed in colorectal tumors.
Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (show C13orf15 Antibodies) progression and a negative regulator of CREB1 (show CREB1 Antibodies) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.
this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (show PPP2R4 Antibodies) and CaMKI (show CAMK1 Antibodies) and PME-1 (show PPME1 Antibodies) networks may function in fine-tuning cell proliferation and stress response.
a mechanism by which the interplay between SIK2 and p97/VCP (show vcp Antibodies) contributes to the regulation of ERAD in mammalian cells.
These findings revealed a new function of LKB1 (show STK11 Antibodies) and salt-inducible kinases as negative regulators of HTLV-1 transcription.
findings uncover SIK2 as a critical determinant in autophagy progression and further suggest a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis.
In adipocytes, Ser358 (not Ser587) is the main site phosphorylated and responsible for the binding of SIK2 to 14-3-3 (show YWHAQ Antibodies) proteins.
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
salt-inducible kinase 2
, SNF1-like kinase 2
, salt induceable kinase 2
, salt-inducible protein kinase 2
, serine/threonine-protein kinase SIK2
, serine/threonine-protein kinase SNF1-like kinase 2
, qin-induced kinase
, salt-inducible serine/threonine kinase 2