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SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. Additionally we are shipping SELPLG Kits (29) and SELPLG Proteins (13) and many more products for this protein.
Showing 10 out of 262 products:
Human Monoclonal SELPLG Primary Antibody for CyTOF, ELISA - ABIN262947
Walcheck, Leppanen, Cummings, Knibbs, Stoolman, Alexander, Mattila, McEver: The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin. in Blood 2002
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Human Polyclonal SELPLG Primary Antibody for EIA, FACS - ABIN951205
Elmas, Bugert, Popp, Lang, Weiss, Behnes, Borggrefe, Kälsch: The P-selectin gene polymorphism Val168Met: a novel risk marker for the occurrence of primary ventricular fibrillation during acute myocardial infarction. in Journal of cardiovascular electrophysiology 2010
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Human Monoclonal SELPLG Primary Antibody for FACS - ABIN489932
Marsik, Mayr, Cardona, Schaller, Wagner, Jilma: Endotoxin down-modulates P-selectin glycoprotein ligand-1 (PSGL-1, CD162) on neutrophils in humans. in Journal of clinical immunology 2004
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Human Monoclonal SELPLG Primary Antibody for Func, FACS - ABIN319877
Laszik, Jansen, Cummings, Tedder, McEver, Moore: P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. in Blood 1996
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Human Monoclonal SELPLG Primary Antibody for IHC (fro), IHC (p) - ABIN118928
Moore, Patel, Bruehl, Li, Johnson, Lichenstein, Cummings, Bainton, McEver: P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. in The Journal of cell biology 1995
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Human Polyclonal SELPLG Primary Antibody for FACS, WB - ABIN654425
Luan, Boulanger, Ye, Chanudet, Johnson, Hamoudi, Bacon, Liu, Huang, Said, Chu, Clemen, Cesarman, Chadburn, Isaacson, Du: Primary effusion lymphoma: genomic profiling revealed amplification of SELPLG and CORO1C encoding for proteins important for cell migration. in The Journal of pathology 2010
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Human Monoclonal SELPLG Primary Antibody for FACS - ABIN488144
Desai, Mitchison: A new role for motor proteins as couplers to depolymerizing microtubules. in The Journal of cell biology 1995
this study shows that PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment
Psgl-1 deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT (show AKT1 Antibodies) axis.
Circulating soluble P-selectin (show SELP Antibodies) must dimerize to promote inflammation and thrombosis in mice.
The results from the present study suggest that activated platelets secrete Pselectin to promote cardiac inflammation and fibrosis in Ang (show ANG Antibodies) IIinduced hypertension.
These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP Antibodies) in platelets, followed by activation and secretion of Asm (show SMPD1 Antibodies) and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 Antibodies) acts downstream from P-selectin (show SELP Antibodies) and is necessary for the secretion of Asm (show SMPD1 Antibodies).
Psgl-1 deficiency is protective against the prothrombotic effects of IL-1beta (show IL1B Antibodies) .
PSGL-1, CD43, and CD44 moved normally to the uropods of chemokine-stimulated C1galt1(-/-) neutrophils
these results demonstrate that P-selectin (show SELP Antibodies) expression on ECs is regulated in part by glycosylation mechanisms and that glycosylation inhibitors efficiently reduce the adhesion of sRBCs and leukocytes to ECs.
endothelial colony-forming cells interact with (show SELL Antibodies)activated neutrophils via PSGL-1 and L-selectin
In the absence of either PSGL-1 or E- and P-selectin (show SELP Antibodies).
The percentage of CXCR3 (show CXCR3 Antibodies)(+) CD4 (show CD4 Antibodies)(+) TEM (show CYLD Antibodies) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4 (show CD4 Antibodies)(+) TCM cells expressing CCR6 (show CCR6 Antibodies)(+) or CCR4 (show CCR4 Antibodies)(+)CXCR3 (show CXCR3 Antibodies)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Platelet-leukocyte aggregations increased in acute ischemic stroke patients rapidly within 3h. The I allele of PSGL-1 M62I was associated with risk of developing acute ischemic stroke, especially large artery atherosclerosis stroke and small artery occlusion stroke. Small artery occlusion stroke patients with the II genotype of PSGL-1 M62I have the higher level of platelet-neutrophil aggregates.
The significant presence of CLA+ T cells and E-selectin (show SELE Antibodies) expressions in the OLPG suggests their involvement in the etiopathogenesis of OLP; however, only a weak correlation between CLA+ T cells and E-selectin (show SELE Antibodies) was observed.
PSGL-1 is a novel receptor for S. pneumoniae that contributes to protection against invasive pneumococcal disease.
This study provides a better understanding of the biology of P-selectin (show SELP Antibodies) and PSGL-1 and their roles in dissemination and resensitization of Multiple myeloma treatment.
Report influence of SELPLG variation on leukocyte-platelet interactions in cardiovascular disease.
E-selectin (show SELE Antibodies) interactions with glycoprotein ligands (CD44 (show CD44 Antibodies)/hematopoietic cell E-/L-selectin (show SELL Antibodies) ligand and PSGL-1) mediate the initial capturing of cells out of flow.
CD162 staining and the staining degree, with the other standard immunohistochemical stains, were shown to be beneficial in the diagnosis of multiple myeloma disease.
The solution structure of CCL19 (show CCL19 Antibodies) is reported. It contains a canonical chemokine (show CCL1 Antibodies) domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 (show CCR7 Antibodies) have overlapping binding sites for CCL19 (show CCL19 Antibodies) and binding is competitive.
expression of P-selectin (show SELP Antibodies) and P-selectin glycoprotein ligand-1, forming an auto-augmented loop of porcine aortic endothelial cells and platelet activation
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
selectin P ligand
, P-selectin glycoprotein ligand 1
, P-selectin glycoprotein ligand 1 propeptide
, cutaneous lymphocyte-associated associated antigen
, leukocyte cell surface adhesion molecule
, selectin, platelet (p-selectin) ligand
, P-selectin glycoprotein ligand-1
, synaptotagmin-like protein 1