Selectin P Ligand Proteins (SELPLG)

SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. Additionally we are shipping SELPLG Antibodies (262) and SELPLG Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SELPLG 12720  
SELPLG 6404 Q14242
SELPLG 363930  
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Top SELPLG Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Human Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Mammalian Cells Mouse Fc Tag   50 μg Log in to see 4 Days
$313.50
Details
HOST_Human Mouse Fc Tag   10 μg Log in to see 15 to 16 Days
$212.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 2 to 3 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Mouse GST tag,S tag,His tag   100 μg Log in to see 15 to 18 Days
$640.00
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 15 to 18 Days
$672.00
Details

SELPLG Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , , ,
, , ,
Human , ,
, ,
Rat (Rattus)

Top referenced SELPLG Proteins

  1. Mouse (Murine) SELPLG Protein expressed in Human Cells - ABIN2008293 : Sako, Chang, Barone, Vachino, White, Shaw, Veldman, Bean, Ahern, Furie: Expression cloning of a functional glycoprotein ligand for P-selectin. in Cell 1994 (PubMed)
    Show all 5 references for 2008293

  2. Human SELPLG Protein expressed in Human Cells - ABIN2002955 : Pouyani, Seed: PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. in Cell 1995 (PubMed)
    Show all 5 references for 2002955

More Proteins for Selectin P Ligand (SELPLG) Interaction Partners

Mouse (Murine) Selectin P Ligand (SELPLG) interaction partners

  1. this study shows that PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment

  2. Psgl-1 deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT (show AKT1 Proteins) axis.

  3. Circulating soluble P-selectin (show SELP Proteins) must dimerize to promote inflammation and thrombosis in mice.

  4. The results from the present study suggest that activated platelets secrete Pselectin to promote cardiac inflammation and fibrosis in Ang (show ANG Proteins) IIinduced hypertension.

  5. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP Proteins) in platelets, followed by activation and secretion of Asm (show SMPD1 Proteins) and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 Proteins) acts downstream from P-selectin (show SELP Proteins) and is necessary for the secretion of Asm (show SMPD1 Proteins).

  6. Psgl-1 deficiency is protective against the prothrombotic effects of IL-1beta (show IL1B Proteins) .

  7. PSGL-1, CD43, and CD44 moved normally to the uropods of chemokine-stimulated C1galt1(-/-) neutrophils

  8. these results demonstrate that P-selectin (show SELP Proteins) expression on ECs is regulated in part by glycosylation mechanisms and that glycosylation inhibitors efficiently reduce the adhesion of sRBCs and leukocytes to ECs.

  9. endothelial colony-forming cells interact with (show SELL Proteins)activated neutrophils via PSGL-1 and L-selectin

  10. In the absence of either PSGL-1 or E- and P-selectin (show SELP Proteins).

Human Selectin P Ligand (SELPLG) interaction partners

  1. The percentage of CXCR3 (show CXCR3 Proteins)(+) CD4 (show CD4 Proteins)(+) TEM (show CYLD Proteins) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4 (show CD4 Proteins)(+) TCM cells expressing CCR6 (show CCR6 Proteins)(+) or CCR4 (show CCR4 Proteins)(+)CXCR3 (show CXCR3 Proteins)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

  2. Platelet-leukocyte aggregations increased in acute ischemic stroke patients rapidly within 3h. The I allele of PSGL-1 M62I was associated with risk of developing acute ischemic stroke, especially large artery atherosclerosis stroke and small artery occlusion stroke. Small artery occlusion stroke patients with the II genotype of PSGL-1 M62I have the higher level of platelet-neutrophil aggregates.

  3. The significant presence of CLA+ T cells and E-selectin (show SELE Proteins) expressions in the OLPG suggests their involvement in the etiopathogenesis of OLP; however, only a weak correlation between CLA+ T cells and E-selectin (show SELE Proteins) was observed.

  4. PSGL-1 is a novel receptor for S. pneumoniae that contributes to protection against invasive pneumococcal disease.

  5. This study provides a better understanding of the biology of P-selectin (show SELP Proteins) and PSGL-1 and their roles in dissemination and resensitization of Multiple myeloma treatment.

  6. Report influence of SELPLG variation on leukocyte-platelet interactions in cardiovascular disease.

  7. E-selectin (show SELE Proteins) interactions with glycoprotein ligands (CD44 (show CD44 Proteins)/hematopoietic cell E-/L-selectin (show SELL Proteins) ligand and PSGL-1) mediate the initial capturing of cells out of flow.

  8. CD162 staining and the staining degree, with the other standard immunohistochemical stains, were shown to be beneficial in the diagnosis of multiple myeloma disease.

  9. The solution structure of CCL19 (show CCL19 Proteins) is reported. It contains a canonical chemokine (show CCL1 Proteins) domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 (show CCR7 Proteins) have overlapping binding sites for CCL19 (show CCL19 Proteins) and binding is competitive.

  10. expression of P-selectin (show SELP Proteins) and P-selectin glycoprotein ligand-1, forming an auto-augmented loop of porcine aortic endothelial cells and platelet activation

SELPLG Protein Profile

Protein Summary

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Selectin P Ligand Proteins (SELPLG)

  • selectin P ligand (SELPLG)
  • clasper (cla)
  • selectin P ligand (Selplg)
  • selectin, platelet (p-selectin) ligand (Selplg)
  • synaptotagmin-like 1 (Sytl1)
  • 9030417L18 protein
  • CD162 protein
  • CLA protein
  • Psgl-1 protein
  • Psgl1 protein
  • Selp1 protein
  • SELPG protein
  • Selpl protein
  • SELPLG protein
  • Slp1 protein

Protein level used designations for Selectin P Ligand Proteins (SELPLG)

selectin P ligand , P-selectin glycoprotein ligand 1 , P-selectin glycoprotein ligand 1 propeptide , cutaneous lymphocyte-associated associated antigen , leukocyte cell surface adhesion molecule , selectin, platelet (p-selectin) ligand , P-selectin glycoprotein ligand-1 , exophilin-7 , synaptotagmin-like protein 1

GENE ID SPECIES
452211 Pan troglodytes
611673 Canis lupus familiaris
617434 Bos taurus
100034025 Equus caballus
100125963 Sus scrofa
12720 Mus musculus
6404 Homo sapiens
363930 Rattus norvegicus
20345 Mus musculus
269589 Mus musculus
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