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anti-Shugoshin-Like 2 (S. Pombe) (SGOL2) Antibodies

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SGOL2 151246 Q562F6
SGOL2 68549 Q7TSY8
SGOL2    
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Top anti-Shugoshin-Like 2 (S. Pombe) Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using SGOL2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IP Western Blot: SGO2 Antibody [ABIN253072] - Detection of Human SGO2 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SGO2 antibody ABIN253072 used for IP at 3 mcg/mg lysate. SGO2 was also immunoprecipitated by rabbit anti-SGO2 antibody ABIN253073, which recognizes a downstream epitope. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated WB SGOL2 Antibody (Center) (ABIN1881800) western blot analysis in U-937 cell line lysates (35 µg/lane). This demonstrates the SGOL2 antibody detected the SGOL2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: SGOL2 Antibody [NBP1-83567] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: SGOL2 Antibody [NBP1-83567] - Staining of human testis shows strong nuclear positivity in cells of seminiferus ducts. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IP, WB Western Blot and Immunoprecipitation: SGO2 Antibody [ABIN253073] - Detection of Human SGO2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- SGO2 antibody ABIN253073 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. SGO2 was also immunoprecipitated by rabbit anti-SGO2 antibody ABIN253072, which recognizes an upstream epitope.  Detection: Chemiluminescence with exposure times of 10 seconds (A) and 3 minutes (B). 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 14 Days
$175.80
Details
Human Rabbit Un-conjugated ELISA, IHC (p)   100 μL Log in to see 7 to 9 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 7 to 9 Days
$713.17
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 7 to 9 Days
$969.83
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 7 to 9 Days
$969.83
Details

SGOL2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,


, , , , ,
Mouse (Murine)


Monkey


Top referenced anti-Shugoshin-Like 2 (S. Pombe) Antibodies

  1. Human Polyclonal SGOL2 Primary Antibody for WB - ABIN1881800 : Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres. in Genes & development 2010 (PubMed)
    Show all 5 references for ABIN1881800

  2. Human Polyclonal SGOL2 Primary Antibody for IHC, ELISA - ABIN1535371 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)

  3. Human Polyclonal SGOL2 Primary Antibody for ICC, IF - ABIN4353216 : Lindsey, Byrnes, Eller, Rosa, Dabas, Escandon, Grichnik: Potential role of meiosis proteins in melanoma chromosomal instability. in Journal of skin cancer 2013 (PubMed)

  4. Human Polyclonal SGOL2 Primary Antibody for IP - ABIN253072 : Deeraksa, Pan, Sha, Liu, Eissa, Lin, Yu-Lee: Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis. in Oncogene 2013 (PubMed)

More Antibodies against Shugoshin-Like 2 (S. Pombe) Interaction Partners

Human Shugoshin-Like 2 (S. Pombe) (SGOL2) interaction partners

  1. Sgol2's ability to protect cohesin depends on its interaction with PP2A (show PPP2R4 Antibodies), as is its ability to silence the SAC (show ADCY10 Antibodies), with the latter being mediated by direct binding to Mad2 (show MAD2L1 Antibodies)

  2. identified the phosphorylation of hSgo2 by Aurora B (show AURKB Antibodies) at the N-terminal coiled-coil region and the middle region, and showed that these phosphorylations separately promote binding of hSgo2 to PP2A (show PPP2R4 Antibodies) and MCAK (show KIF2C Antibodies)

Mouse (Murine) Shugoshin-Like 2 (S. Pombe) (SGOL2) interaction partners

  1. Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body 'knob'.

  2. Results show that shugoshin Sgo2 is expressed in germ cells.

  3. SGOL2 is necessary for protecting centromeric cohesion during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a premature release of the meiosis-specific REC8 cohesin complexes from anaphase I centromeres

  4. Shugoshin 2 is necessary for the loading of MCAK (show KIF2C Antibodies) at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 (show BUB1B Antibodies) and CENP-E (show CENPE Antibodies).

Shugoshin-Like 2 (S. Pombe) (SGOL2) Antigen Profile

Protein Summary

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Gene names and symbols associated with SGOL2

  • shugoshin-like 2 (S. pombe) (SGOL2) antibody
  • shugoshin-like 2 (S. pombe) (Sgol2) antibody
  • 1110007N04Rik antibody
  • 4932411A20Rik antibody
  • 5730576N04Rik antibody
  • AU018846 antibody
  • AV008062 antibody
  • D1Ertd8e antibody
  • SGO2 antibody
  • Tripin antibody

Protein level used designations for SGOL2

shugoshin-2 , shugoshin-like 2 , sgo2

GENE ID SPECIES
151246 Homo sapiens
68549 Mus musculus
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