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anti-Sirtuin 2 (SIRT2) Antibodies

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 2 Kits (23) and Sirtuin 2 Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Top anti-Sirtuin 2 Antibodies at antibodies-online.com

Showing 10 out of 124 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemical staining of human brain tissue using AP30786PU-N at 2.5 μg/ml. Western blot analysis of SIRT2 in human brain lysate with this product at (A) 2.5 and (B) 5 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemical staining of human brain tissue using AP30785PU-N SIRT2 antibody at 2.5 μg/ml. Western blot analysis of SIRT2 in Mouse brain lysate with AP30785PU-N SIRT2 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SIRT2 Picoband antibody,  IHC(P): Rat Brain Tissue Anti-SIRT2 Picoband antibody,  IHC(P): Mouse Brain Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB Immunofluorescence: Sirtuin 2/SIRT2 Antibody [NBP1-76879] - Human Brain tissue with SIRT2 antibody at 5 ug/mL. Immunohistochemistry: Sirtuin 2/SIRT2 Antibody [NBP1-76879] - Immunohistochemical staining of Human Brain tissue using SIRT2 antibody at 2.5 ug/mL. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rat Un-conjugated WB   100 μg Log in to see 1 to 2 Days
$495.83
Details

SIRT2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sirtuin 2 Antibodies

  1. Human Polyclonal SIRT2 Primary Antibody for EIA, IHC (p) - ABIN500724 : Yamamoto, Schoonjans, Auwerx: Sirtuin functions in health and disease. in Molecular endocrinology (Baltimore, Md.) 2007 (PubMed)
    Show all 5 references for ABIN500724

  2. Human Polyclonal SIRT2 Primary Antibody for EIA, IHC (p) - ABIN500726 : North, Marshall, Borra, Denu, Verdin: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. in Molecular cell 2003 (PubMed)
    Show all 4 references for ABIN500726

  3. Cow (Bovine) Polyclonal SIRT2 Primary Antibody for WB - ABIN493462 : Jing, Gesta, Kahn: SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. in Cell metabolism 2007 (PubMed)
    Show all 3 references for ABIN493462

  4. Cow (Bovine) Polyclonal SIRT2 Primary Antibody for WB - ABIN2779604 : Borra, Langer, Slama, Denu: Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. in Biochemistry 2004 (PubMed)
    Show all 2 references for ABIN2779604

  5. Human Monoclonal SIRT2 Primary Antibody for WB - ABIN2668612 : Pandithage, Lilischkis, Harting, Wolf, Jedamzik, Lüscher-Firzlaff, Vervoorts, Lasonder, Kremmer, Knöll, Lüscher: The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. in The Journal of cell biology 2008 (PubMed)

  6. Human Polyclonal SIRT2 Primary Antibody for ELISA, ICC - ABIN4353911 : Zhao, Mo, Li, Zou, Cheng, Sun, Xiong, Guan, Lei: NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. in The Journal of clinical investigation 2014 (PubMed)

  7. Human Polyclonal SIRT2 Primary Antibody for ELISA, WB - ABIN1452045 : Afshar, Murnane: Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. in Gene 1999 (PubMed)

More Antibodies against Sirtuin 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) interaction partners

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) interaction partners

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (show TMEM37 Antibodies) expression.

Human Sirtuin 2 (SIRT2) interaction partners

  1. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein (show SNCA Antibodies) acetylation, its aggregation, and autophagy.

  2. the tissue from lymph node metastases appears to have a significant upregulation of SIRT2 relative to primary tumors across the nuclear, cytoplasmic, and whole cell data.

  3. Data show that SIRT2 interacts with multiple intracellular trafficking proteins and showed that majority of its interactions are of transient nature. Also, It confirms its colocalization with ER-Golgi intermediate compartment.

  4. The levels of SPOP (show SPOP Antibodies) significantly decreased, while the levels of SIRT2 significantly increased in non-small cell lung cancer (NSCLC) cell lines, compared to normal bronchial epithelial cell line and NSCLC specimens, compared to the paired non-tumor lung tissue.

  5. SIRT2 is a promising marker of cellular senescence at least in cells with wild type p53 (show TP53 Antibodies) status.

  6. The results suggest that Sirt2 plays a crucial role in neuronal differentiation via the ERK (show EPHB2 Antibodies)-CREB (show CREB1 Antibodies) signaling pathway.

  7. Reduced SIRT2 expression during tumorigenesis failed to repress cyclindependent kinase 4 expression, which eventually led to accelerated cell proliferation.

  8. Sirt-2 is recruited to NF-kappaB (show NFKB1 Antibodies) target gene promoter via interaction with core histones.

  9. Study demonstrate that PRL (show PRL Antibodies) is necessary for the survival of (retinal pigment epithelium) RPE (show RPE Antibodies) under normal and advancing age conditions and, identified SIRT2 and TRPM2 (show CLU Antibodies) as molecular targets for the antioxidant and antiapoptotic actions of PRL (show PRL Antibodies) in the RPE (show RPE Antibodies).

  10. 4-oxo-2-nonenal reacts with histone lysine residues to form a new histone modification, gamma-oxononanoylation (Kgon). human Sirt2 catalyzes the removal of histone Kgon.

Cow (Bovine) Sirtuin 2 (SIRT2) interaction partners

  1. The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (show CALCA Antibodies)-) diplotypes performed better than other combinations.

  3. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) interaction partners

  1. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein (show SNCA Antibodies) acetylation, its aggregation, and autophagy.

  2. QKI (show QKI Antibodies) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 to facilitate oligodendrocyte differentiation.

  3. Sirt2-knockout mice were less susceptible to the development of hepatic fibrosis induced by carbon tetrachloride or thioacetamide.

  4. Results suggest a role for Hdac5 (show HDAC5 Antibodies) and Sirt2 in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression

  5. Sirt2 deletion results in radiation-induced alteration of the mouse brain proteome.

  6. Sirt2 expression has a transitory effect in M. tuberculosis infection

  7. we postulate that Sirt2 mediates myelin-dependent neuronal dysfunction during the early phase after ischemic stroke

  8. The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha (show PLA2G4A Antibodies)) acts as a bridge in this complex to promote binding of SIRT2 to cyclin A (show CCNA2 Antibodies)-Cdk2 (show CDK2 Antibodies).

  9. Lipopolysaccharide-induced increases in microglia NOS (show NOS Antibodies) and cytokine mRNA were attenuated in the cells with SIRT2 silencing-produced decreases in the SIRT2 level. This suggests that SIRT2 is required for lipopolysaccharide-induced microglial activation

  10. Disruption of the SIRT2-beta-catenin (show CTNNB1 Antibodies) interaction represents an endogenous therapeutic target to prevent transformation and preserve the integrity of aging cells against exogenous stressors such as reactive oxygen species.

Sirtuin 2 (SIRT2) Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Gene names and symbols associated with anti-Sirtuin 2 (SIRT2) Antibodies

  • CG5085 gene product from transcript CG5085-RA (Sirt2) antibody
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2) antibody
  • sirtuin 2 (sir2) antibody
  • sirtuin 2 (SIRT2) antibody
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2) antibody
  • sirtuin 2 (SRT2) antibody
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2) antibody
  • sirtuin 2 (Sirt2) antibody
  • 5730427M03Rik antibody
  • AtSRT2 antibody
  • BmSirt2 antibody
  • CG5085 antibody
  • D.mel2 antibody
  • Dmel\\CG5085 antibody
  • dSIRT2 antibody
  • SIR2 antibody
  • Sir2l antibody
  • SIR2L2 antibody
  • Sirt2 antibody
  • sirtuin 2 antibody
  • T2K12.8 antibody
  • wu:fb57d05 antibody
  • zgc:55966 antibody
  • zgc:77003 antibody

Protein level used designations for anti-Sirtuin 2 (SIRT2) Antibodies

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

GENE ID SPECIES
42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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