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SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 2 Antibodies (125) and Sirtuin 2 Kits (26) and many more products for this protein.
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Sirt2 has an role in the regulation of mitochondrial energy metabolism.
SRT2 is important in fine-tuning mitochondrial energy metabolism.
AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (show TMEM37 Proteins) expression.
BEX4 (show BEX4 Proteins) overexpression causes an imbalance between TUB (show TUB Proteins) acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.
SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2 (show NFE2 Proteins)-related factor 2 (NRF2 (show GABPA Proteins)) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 (show GABPA Proteins) levels.
Identify the miR (show MLXIP Proteins)-200c-SIRT2 axis as a key regulator of metabolic reprogramming (Warburg-like effect), via regulation of glycolytic enzymes, during human induced pluripotency and pluripotent stem cell function.
Four novel heterozygous DNA sequence variants and five SNPs of sirt2 protein were found in both acute myocardial infarction patients and control with similar frequencies.
These results indicate overlapping and distinct functions of HDAC6 (show HDAC6 Proteins) and SIRT2.
ANKLE2 acetylation at K302 and phosphorylation at S662 are dynamically regulated throughout the cell cycle by SIRT2 and are essential for normal nuclear envelope reassembly.
our findings suggest that the tumor suppressor activity of SIRT2 requires its ability to restrict the antioxidant activity of Prdx-1 (show PRDX1 Proteins), thereby sensitizing breast cancer cells to reactive oxygen species -induced DNA damage and cell cytotoxicity
Data suggest that SIRT2 exhibits tumor-suppressive function in which somatic mutations in SIRT2 contribute to genomic instability by impairing deacetylase activity of SIRT2 or diminishing its protein levels in the DNA-damage/repair response.
Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.
the tissue from lymph node metastases appears to have a significant upregulation of SIRT2 relative to primary tumors across the nuclear, cytoplasmic, and whole cell data.
The results indicate that the variations in the class I sirtuin (show SIRT1 Proteins) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (show CALCA Proteins)-) diplotypes performed better than other combinations.
Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.
mitochondrial dysfunction triggers LKB1 (show STK11 Proteins)-mediated AMPK (show PRKAA1 Proteins) activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR (show FRAP1 Proteins)-RAPTOR (show RPTOR Proteins) and Glut1 (show SLC2A1 Proteins)-mediated glucose uptake.
SIRT-2 regulates microvascular inflammation in obese mice with sepsis.
Loss of SIRT2 expression is associated with breast Cancer.
QKI (show QKI Proteins) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 to facilitate oligodendrocyte differentiation.
Sirt2-knockout mice were less susceptible to the development of hepatic fibrosis induced by carbon tetrachloride or thioacetamide.
Results suggest a role for Hdac5 (show HDAC5 Proteins) and Sirt2 in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression
Sirt2 deletion results in radiation-induced alteration of the mouse brain proteome.
Sirt2 expression has a transitory effect in M. tuberculosis infection
we postulate that Sirt2 mediates myelin-dependent neuronal dysfunction during the early phase after ischemic stroke
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
, sirtuin 2
, NAD-dependent deacetylase SIRT2
, NAD-dependent deacetylase sirtuin-2
, histone NADC
, silent information regulator 2
, nicotinamide adenine dinucleotide-dependent histone deacetylase
, NAD-dependent deacetylase sirtuin 2 homolog
, NAD-dependent protein deacetylase sirtuin-2
, SIR2-like protein 2
, regulatory protein SIR2 homolog 2
, sir2-related protein type 2
, sirtuin type 2
, sirtuin-like protein 2
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
, 5E5 antigen