anti-Sirtuin 3 (SIRT3) Antibodies

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (27) and SIRT3 Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top anti-SIRT3 Antibodies at antibodies-online.com

Showing 10 out of 235 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIRT3 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: Human Thymus 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB <b>WB Suggested Anti-SIRT3 Antibody Titration: </b>2.5ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Hamster Rabbit Un-conjugated IHC (p), WB Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in mouse brain tissue lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in CHO cell line lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Anti-SIRT3 Picoband antibody,  All lanes: Anti SIRT3  at 0.5ug/ml WB: Recombinant Human SIRT3 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD Observed bind size: 44KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT3 antibody (ABIN390178) in Y79 cell line lysates (35 µg/lane). SIRT3 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185498 (0.2µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Goat Un-conjugated ELISA, WB Western Blot: SIRT3 Antibody [ABIN269822] - Western blot analysis of SIRT3 in Human Liver lysate using this antibody at 0.2 ug/ml. Western Blot: SIRT3 Antibody [ABIN269822] - HEK293 overexpressing SIRT3 and probed with (mock transfection in first lane). 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Dog Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details

SIRT3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIRT3 Antibodies

  1. Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178 : Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010 (PubMed)
    Show all 11 Pubmed References

  2. Cow (Bovine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610 : Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822 : Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 Pubmed References

  4. Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184 : Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010 (PubMed)
    Show all 2 Pubmed References

More Antibodies against SIRT3 Interaction Partners

Human Sirtuin 3 (SIRT3) interaction partners

  1. Contrary to what has been known in solid tumors, in K562 human leukemia cells, Sirt3 plays an opposite role in relieving oxidative stress. Basal but not enhanced autophagy activity maintains ubiquitination-proteasomal degradation of Sirt3 to limit reactive oxygen species level.

  2. SIRT3 whole muscle protein content was unaltered after fasting.

  3. Current study reveal Sirt3 as a novel regulator coupling mitophagy and apoptosis, two important cellular processes that determine cellular survival and death.

  4. The function of the three mitochondrial sirtuins (SIRT3, SIRT4 (show SIRT4 Antibodies), SIRT5 (show SIRT5 Antibodies)) and their role in disease are reviewed.

  5. Results show that curcumin at low doses can increase the level of sirtuins including sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3) without delaying senescence of vascular smooth muscle (VSMC) cells.

  6. survival curves showed that higher SIRT3 expression is correlated to a poorer prognosis for patients with grade 3 breast cancer. In conclusion, SIRT3 could be a therapeutic target for breast cancer, improving the effectiveness of CDDP and TAM (show CCNA1 Antibodies) treatments.

  7. There were no significant correlations between LRP130 (show LRPPRC Antibodies), SIRT3, or PGC-1alpha (show PPARGC1A Antibodies) mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130 (show LRPPRC Antibodies), SIRT3, and PGC-1alpha (show PPARGC1A Antibodies) were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.

  8. In human myometrium, SIRT3 expression decreases with term labor and regulates the mediators involved in the terminal effector pathways of human labor and delivery through the NFkappaB1 pathway.

  9. Mitochondria-targeted esculetin has anti-atherosclerotic effects by inhibiting PAI-1 (show SERPINE1 Antibodies) levels by modulating miR (show MLXIP Antibodies)-19b and -30c expression and affecting SIRT3- and STAT3 (show STAT3 Antibodies)-mediated signaling pathways.

  10. the activation of the SIRT3 axis of the UPRmt is linked to metastasis.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

  1. conclude that Sirt3 does not considerably impact NET formation, platelet function, or venous thrombosis in healthy young mice

  2. vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 expression and AMPK (show PRKAA1 Antibodies) phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3/AMPK (show PRKAA1 Antibodies)/autophagy network orchestrates in the protective effect of resveratrol in macrophages.

  3. Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC (show PGC Antibodies)-1a-SOD2 (show SOD2 Antibodies)-mediated regulation of mitochondrial function

  4. findings reveal an unexpected mechanism for SIRT3 regulation via SIRT1 (show SIRT1 Antibodies)-mediated deacetylation. Improving mitochondrial SIRT3 functions by inhibiting SIRT3 acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.

  5. Sirt3 expression in bone marrow cells increases during aging, suggesting that Sirt3 promotes age-related adipogenesis and osteoclastogenesis associated with bone loss. These findings identify Sirt3 as an important regulator of adipogenesis and skeletal homeostasis in vivo and identify Sirt3 as a potential target for the treatment of osteoporosis.

  6. These data suggest a novel role for SIRT3 deficiency in mediating alveolar epithelial cell mtDNA damage, apoptosis, and lung fibrosis.-

  7. Diminished Sirt3 expression and redox inactivation of Sirt3 led to SOD2 (show SOD2 Antibodies) inactivation and contributes to hypertension.

  8. Data suggest that negative regulatory effect of Sirt3 on Nlrp3 (show NLRP3 Antibodies) inflammasome assembly in macrophages due to prolonged fasting occurs via Sirt3-mediated deacetylation of mitochondrial Sod2 (show SOD2 Antibodies), leading to Sod2 (show SOD2 Antibodies) activation; prolonged fasting blunts inflammasomes in wild-type mice but not in Sirt3 knock-out mice. (Sirt3 = sirtuin 3; Nlrp3 (show NLRP3 Antibodies) = NLR (show CXCR5 Antibodies) family, pyrin domain containing 3 protein; Sod2 (show SOD2 Antibodies) = superoxide dismutase 2 (show SOD2 Antibodies))

  9. Results reveal a potential mechanism by which SIRT3 deletion exacerbates post-MI cardiac dysfunction and impairment of cardiac recovery involving microvascular rarefaction and pre-existing coronary microvascular dysfunction.

  10. expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

  1. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.

  2. The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  3. The expression profile of sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with anti-Sirtuin 3 (SIRT3) Antibodies

  • sirtuin 3 (sirt3) antibody
  • sirtuin 3 (SIRT3) antibody
  • sirtuin 3 (Sirt3) antibody
  • 2310003L23Rik antibody
  • AI848213 antibody
  • Sir2l3 antibody
  • sirtuin antibody
  • zgc:158774 antibody

Protein level used designations for anti-Sirtuin 3 (SIRT3) Antibodies

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPECIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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