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SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (18) and SIRT3 Proteins (15) and many more products for this protein.
Showing 10 out of 236 products:
Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178
Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010
Show all 11 references for ABIN390178
Dog (Canine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610
Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 3 references for ABIN2779610
Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822
Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005
Show all 2 references for ABIN269822
Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184
Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010
Show all 2 references for ABIN652184
Human Polyclonal SIRT3 Primary Antibody for EIA, IHC (p) - ABIN358732
Sundaresan, Samant, Pillai, Rajamohan, Gupta: SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. in Molecular and cellular biology 2008
Human Polyclonal SIRT3 Primary Antibody for EIA, WB - ABIN783622
Guarente: Sirtuins as potential targets for metabolic syndrome. in Nature 2006
Human Polyclonal SIRT3 Primary Antibody for WB - ABIN2779611
Bellizzi, Rose, Cavalcante, Covello, Dato, De Rango, Greco, Maggiolini, Feraco, Mari, Franceschi, Passarino, De Benedictis: A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. in Genomics 2005
This study underscores an essential role of SIRT3 in the antitumor effect of Bcl-2 (show BCL2 Antibodies) inhibitors in human ovarian cancer through regulating both metabolism and apoptosis. The manipulation of Bcl-2 (show BCL2 Antibodies) inhibitors combined with the use of classic glycolysis inhibitors may be rational strategies to improve ovarian cancer therapy.
Results elucidated the function of SIRT3 in hepatocellular carcinoma development and suggested that SIRT3 might function as tumor suppressor in hepatocellular carcinoma by targeting PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway.
Dissection of subnetwork architecture led to identification of a fundamental role for SIRT3 in homeostasis of mitochondrial membrane potential. In total, 89 interacting proteins were identified, and extensive validation points to the robustness of the derived network.
SIRT3 overexpression dramatically increased cell viability in a cell model of Parkinson's disease.
Insufficient expression of Sirt3 leads to inefficient mitochondrial biogenesis with decreased developmental competence of human in vitro matured oocytes.
SIRT3 overexpression disrupts mitochondrial proteostasis that causes overproduction of reactive oxygen species and the cell cycle arrest to suppress cell proliferation.
Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Antibodies)), endometrial cancer (EC) showed SIRT7 (show SIRT7 Antibodies) mRNA overexpression, whereas SIRT1 (show SIRT1 Antibodies), SIRT2 (show SIRT2 Antibodies), SIRT4 (show SIRT4 Antibodies) and SIRT5 (show SIRT5 Antibodies) were underexpressed, and no significant differences were observed for SIRT3 and SIRT6 (show SIRT6 Antibodies).
microseed matrix seeding (MMS) was used to obtain crystals of human Sirt3 in its apo form and of human Sirt2 in complex with ADP ribose (ADPR).
The results suggest that NRF-2 (show GABPA Antibodies) is a regulator of SIRT3 expression and may shed light on how SIRT3 is upregulated during nutrient stress.
Data suggest that DNA sequence variants (DSVs) identified in myocardial infarction (MI) patients may change sirtuin 3 (SIRT3) level by affecting the transcriptional activity of SIRT3 gene promoter, contributing to the MI development as a risk factor.
Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha (show PPARGC1A Antibodies)) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5 (show SIRT5 Antibodies)).
These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 (show UCP2 Antibodies) and SirT3.
despite pre-existing defects in cardiac function and mitochondrial respiratory capacity in SIRT3(-/-) mice, SIRT3 deficiency does not additionally impair cardiac function following myocardial ischemia-reperfusion injury or following myocardial infarction
In the cochlea, the expression of SIRT1 (show SIRT1 Antibodies), 3, and 5 (both mRNA and protein) was decreased in the old mice
SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration.
Results point to an antioxidant defense mechanism presented by Sirt3 through the activation of Foxo3a (show FOXO3 Antibodies), in microglia
Sirt3 activation protects the heart from doxorubicin-induced cardiotoxicity by maintaining OGG1 (show OGG1 Antibodies) levels and protecting mitochondria from DNA damage.
CerS1 (show CERS1 Antibodies), -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice.
as compared to Sirt3 overexpressed and normal groups, the acetylation of IDH2 (show IDH2 Antibodies) and accumulation of ox-LDL were significantly higher in the Sirt3 inhibited group
Sirt3-dependent deacetylation of SOD2 (show SOD2 Antibodies) plays a protective role against oxidative stress and meiotic defects in oocytes under maternal obese conditions.
The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
The expression profile of sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
, NAD-dependent deacetylase sirtuin-3, mitochondrial
, NAD-dependent protein deacetylase sirtuin-3, mitochondrial
, SIR2-like protein 3
, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
, regulatory protein SIR2 homolog 3
, silent mating type information regulation 2, S.cerevisiae, homolog 3
, sir2-like 3
, sirtuin type 3
, SIRT3 mitochondrial
, NAD-dependent deacetylase sirtuin-3
, NAD-dependent protein deacetylase sirtuin-3
, SIRT3L mitochondrial
, mitochondrial protein lysine deacetylase
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3