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SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (19) and SIRT3 Proteins (15) and many more products for this protein.
Showing 10 out of 235 products:
Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178
Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010
Show all 11 references for 390178
Cow (Bovine) Polyclonal SIRT3 Primary Antibody for WB - ABIN493464
Jing, Gesta, Kahn: SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. in Cell metabolism 2007
Show all 4 references for 493464
Cow (Bovine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610
Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822
Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005
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Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184
Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010
Show all 2 references for 652184
Dog (Canine) Polyclonal SIRT3 Primary Antibody for WB - ABIN2779609
Bellizzi, Rose, Cavalcante, Covello, Dato, De Rango, Greco, Maggiolini, Feraco, Mari, Franceschi, Passarino, De Benedictis: A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. in Genomics 2005
Human Polyclonal SIRT3 Primary Antibody for EIA, IHC (p) - ABIN358732
Sundaresan, Samant, Pillai, Rajamohan, Gupta: SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. in Molecular and cellular biology 2008
These data suggest a novel role for SIRT3 deficiency in mediating alveolar epithelial cell mtDNA damage, apoptosis, and lung fibrosis.-
Data suggested a protective role of the SIRT3 single-nucleotide polymorphism rs4980329 in ALS risk.
Low SIRT3 expression is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.
Low SIRT3 expression is associated with Prostate Cancer.
SIRT3 expression was significantly associated with overall survival in gastric cancer (HR = 0.62, 95% CI = 0.43-0.89, P = 0.009) and hepatocellular carcinoma patients (HR = 0.56, 95% CI = 0.42-0.74, P<0.0001), cancer/non-cancer tissues in hepatocellular carcinoma patients (OR = 0.04, 95% CI = 0.01-0.16, P<0.0001), lymph node metastasis in breast cancer patients (OR = 2.20, 95% CI = 1.49-3.26, P<0.0001).
he data demonstrated that linalool exhibited inhibitory effect on glioma cells through regulation of SIRT3-SOD2 (show SOD2 Antibodies)-ROS (show ROS1 Antibodies) signaling
SIRT3 promotes the malignancy of non-small cell lung cancer, showing an oncogenic preference towards squamous cell carcinoma, and that could represent a novel target for treatment.
These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis.
this article indicates a novel functional interplay between estrogen receptor beta (show ESR2 Antibodies) and sirtuin-3 counteracting reactive oxygen species production in TCam-2 cells. Our findings thus show that an important tumor-suppressive pathway through estrogen receptor beta (show ESR2 Antibodies) is target of E2, actually proposing a distinctive protecting action against seminoma.
Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities.
Diminished Sirt3 expression and redox inactivation of Sirt3 led to SOD2 (show SOD2 Antibodies) inactivation and contributes to hypertension.
Data suggest that negative regulatory effect of Sirt3 on Nlrp3 (show NLRP3 Antibodies) inflammasome assembly in macrophages due to prolonged fasting occurs via Sirt3-mediated deacetylation of mitochondrial Sod2 (show SOD2 Antibodies), leading to Sod2 (show SOD2 Antibodies) activation; prolonged fasting blunts inflammasomes in wild-type mice but not in Sirt3 knock-out mice. (Sirt3 = sirtuin 3; Nlrp3 (show NLRP3 Antibodies) = NLR (show CXCR5 Antibodies) family, pyrin domain containing 3 protein; Sod2 (show SOD2 Antibodies) = superoxide dismutase 2 (show SOD2 Antibodies))
Results reveal a potential mechanism by which SIRT3 deletion exacerbates post-MI cardiac dysfunction and impairment of cardiac recovery involving microvascular rarefaction and pre-existing coronary microvascular dysfunction.
expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a (show FOXO3 Antibodies)-mediated mitochondria gene expression of PGC-1alpha (show PPARGC1A Antibodies) and SOD2 (show SOD2 Antibodies).
NMNAT3 (show NMNAT3 Antibodies) regulates the activity of SIRT3 via synthesis of mitochondria NAD.
Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha (show PPARGC1A Antibodies)) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5 (show SIRT5 Antibodies)).
These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 (show UCP2 Antibodies) and SirT3.
The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
The expression profile of sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
, NAD-dependent deacetylase sirtuin-3, mitochondrial
, NAD-dependent protein deacetylase sirtuin-3, mitochondrial
, SIR2-like protein 3
, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
, regulatory protein SIR2 homolog 3
, silent mating type information regulation 2, S.cerevisiae, homolog 3
, sir2-like 3
, sirtuin type 3
, SIRT3 mitochondrial
, NAD-dependent deacetylase sirtuin-3
, NAD-dependent protein deacetylase sirtuin-3
, SIRT3L mitochondrial
, mitochondrial protein lysine deacetylase
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3