Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (19) and SIRT3 Proteins (15) and many more products for this protein.
Showing 10 out of 231 products:
Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178
Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010
Show all 11 references for ABIN390178
Cow (Bovine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610
Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 3 references for ABIN2779610
Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822
Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005
Show all 2 references for ABIN269822
Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184
Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010
Show all 2 references for ABIN652184
Cow (Bovine) Polyclonal SIRT3 Primary Antibody for WB - ABIN2779611
Bellizzi, Rose, Cavalcante, Covello, Dato, De Rango, Greco, Maggiolini, Feraco, Mari, Franceschi, Passarino, De Benedictis: A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. in Genomics 2005
Human Polyclonal SIRT3 Primary Antibody for EIA, WB - ABIN783622
Guarente: Sirtuins as potential targets for metabolic syndrome. in Nature 2006
Human Polyclonal SIRT3 Primary Antibody for EIA, IHC (p) - ABIN358732
Sundaresan, Samant, Pillai, Rajamohan, Gupta: SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. in Molecular and cellular biology 2008
SIRT3 promotes the malignancy of non-small cell lung cancer, showing an oncogenic preference towards squamous cell carcinoma, and that could represent a novel target for treatment.
These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis.
this article indicates a novel functional interplay between estrogen receptor beta (show ESR2 Antibodies) and sirtuin-3 counteracting reactive oxygen species production in TCam-2 cells. Our findings thus show that an important tumor-suppressive pathway through estrogen receptor beta (show ESR2 Antibodies) is target of E2, actually proposing a distinctive protecting action against seminoma.
Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities.
In conclusion, our data suggest that Sirt3 overexpression antagonize high glucose-induced apoptosis by controlling ROS (show ROS1 Antibodies) accumulation and ROS (show ROS1 Antibodies)-sensitive Akt (show AKT1 Antibodies)/FoxO (show FOXO3 Antibodies) signaling pathway in HK-2 (show HK2 Antibodies) cells.
These results suggest that Sirt3 may inhibit retinal neovascularization by regulating the migration-, neovascularization- and autophagy-related factors expression. Thus we argue that Sirt3 may be a potential candidate drug for curing various eye diseases induced by retinal neovascularization.
cells with low SIRT1 (show SIRT1 Antibodies) levels can maintain their resistance and survival by increasing SIRT3 expression.
Our findings suggest that Sirt3 plays a tumor-progressive role in human RCC (show XRCC1 Antibodies) by regulating glutamine (show GFPT1 Antibodies)-derived mitochondrial respiration, particularly in cells where mitochondrial usage of cytosolic pyruvate is severely compromised.
SIRT3 is decreased in the metastatic tissues and highly metastatic cell line of ovarian carcinoma. SIRT3 suppresses ovarian cancer cell migration and invasion in vitro.
Interaction of SIRT3 with the palmitoyl group led to unfolding of the alpha3-helix. The myristoyl and palmitoyl groups bind to the C-pocket and an allosteric site near the alpha3-helix, respectively.
expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a (show FOXO3 Antibodies)-mediated mitochondria gene expression of PGC-1alpha (show PPARGC1A Antibodies) and SOD2 (show SOD2 Antibodies).
NMNAT3 (show NMNAT3 Antibodies) regulates the activity of SIRT3 via synthesis of mitochondria NAD.
Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha (show PPARGC1A Antibodies)) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5 (show SIRT5 Antibodies)).
These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 (show UCP2 Antibodies) and SirT3.
despite pre-existing defects in cardiac function and mitochondrial respiratory capacity in SIRT3(-/-) mice, SIRT3 deficiency does not additionally impair cardiac function following myocardial ischemia-reperfusion injury or following myocardial infarction
In the cochlea, the expression of SIRT1 (show SIRT1 Antibodies), 3, and 5 (both mRNA and protein) was decreased in the old mice
SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration.
Results point to an antioxidant defense mechanism presented by Sirt3 through the activation of Foxo3a (show FOXO3 Antibodies), in microglia
The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
The expression profile of sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
, NAD-dependent deacetylase sirtuin-3, mitochondrial
, NAD-dependent protein deacetylase sirtuin-3, mitochondrial
, SIR2-like protein 3
, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
, regulatory protein SIR2 homolog 3
, silent mating type information regulation 2, S.cerevisiae, homolog 3
, sir2-like 3
, sirtuin type 3
, SIRT3 mitochondrial
, NAD-dependent deacetylase sirtuin-3
, NAD-dependent protein deacetylase sirtuin-3
, SIRT3L mitochondrial
, mitochondrial protein lysine deacetylase
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3