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anti-Sirtuin 3 (SIRT3) Antibodies

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Kits (19) and SIRT3 Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top anti-SIRT3 Antibodies at antibodies-online.com

Showing 10 out of 231 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SIRT3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human Thymus 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-SIRT3 Antibody Titration: 2.5ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Hamster Rabbit Un-conjugated IHC (p), WB Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in mouse brain tissue lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of Sirt3 Antibody (C-term) (ABIN652184) in CHO cell line lysates (35 µg/lane).Sirt3 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT3 antibody (ABIN390178) in Y79 cell line lysates (35 µg/lane). SIRT3 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185498 (0.2µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Chicken Un-conjugated EIA, WB Western blot analysis of SIRT3 in mouse heart tissue lysate with SIRT3 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB Western Blot: SIRT3 Antibody [ABIN269822] - Western blot analysis of SIRT3 in Human Liver lysate using this antibody at 0.2 ug/ml. Western Blot: SIRT3 Antibody [ABIN269822] - HEK293 overexpressing SIRT3 and probed with (mock transfection in first lane). 0.1 mg Log in to see 7 to 9 Days
$408.19
Details

SIRT3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIRT3 Antibodies

  1. Human Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN390178 : Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010 (PubMed)
    Show all 11 references for ABIN390178

  2. Cow (Bovine) Polyclonal SIRT3 Primary Antibody for IHC, WB - ABIN2779610 : Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for ABIN2779610

  3. Human Polyclonal SIRT3 Primary Antibody for ELISA, WB - ABIN269822 : Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN269822

  4. Hamster Polyclonal SIRT3 Primary Antibody for IHC (p), WB - ABIN652184 : Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010 (PubMed)
    Show all 2 references for ABIN652184

  5. Cow (Bovine) Polyclonal SIRT3 Primary Antibody for WB - ABIN2779611 : Bellizzi, Rose, Cavalcante, Covello, Dato, De Rango, Greco, Maggiolini, Feraco, Mari, Franceschi, Passarino, De Benedictis: A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. in Genomics 2005 (PubMed)

  6. Human Polyclonal SIRT3 Primary Antibody for EIA, WB - ABIN783622 : Guarente: Sirtuins as potential targets for metabolic syndrome. in Nature 2006 (PubMed)

  7. Human Polyclonal SIRT3 Primary Antibody for EIA, IHC (p) - ABIN358732 : Sundaresan, Samant, Pillai, Rajamohan, Gupta: SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. in Molecular and cellular biology 2008 (PubMed)

More Antibodies against SIRT3 Interaction Partners

Human Sirtuin 3 (SIRT3) interaction partners

  1. SIRT3 promotes the malignancy of non-small cell lung cancer, showing an oncogenic preference towards squamous cell carcinoma, and that could represent a novel target for treatment.

  2. These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis.

  3. this article indicates a novel functional interplay between estrogen receptor beta (show ESR2 Antibodies) and sirtuin-3 counteracting reactive oxygen species production in TCam-2 cells. Our findings thus show that an important tumor-suppressive pathway through estrogen receptor beta (show ESR2 Antibodies) is target of E2, actually proposing a distinctive protecting action against seminoma.

  4. Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities.

  5. In conclusion, our data suggest that Sirt3 overexpression antagonize high glucose-induced apoptosis by controlling ROS (show ROS1 Antibodies) accumulation and ROS (show ROS1 Antibodies)-sensitive Akt (show AKT1 Antibodies)/FoxO (show FOXO3 Antibodies) signaling pathway in HK-2 (show HK2 Antibodies) cells.

  6. These results suggest that Sirt3 may inhibit retinal neovascularization by regulating the migration-, neovascularization- and autophagy-related factors expression. Thus we argue that Sirt3 may be a potential candidate drug for curing various eye diseases induced by retinal neovascularization.

  7. cells with low SIRT1 (show SIRT1 Antibodies) levels can maintain their resistance and survival by increasing SIRT3 expression.

  8. Our findings suggest that Sirt3 plays a tumor-progressive role in human RCC (show XRCC1 Antibodies) by regulating glutamine (show GFPT1 Antibodies)-derived mitochondrial respiration, particularly in cells where mitochondrial usage of cytosolic pyruvate is severely compromised.

  9. SIRT3 is decreased in the metastatic tissues and highly metastatic cell line of ovarian carcinoma. SIRT3 suppresses ovarian cancer cell migration and invasion in vitro.

  10. Interaction of SIRT3 with the palmitoyl group led to unfolding of the alpha3-helix. The myristoyl and palmitoyl groups bind to the C-pocket and an allosteric site near the alpha3-helix, respectively.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

  1. expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.

  2. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a (show FOXO3 Antibodies)-mediated mitochondria gene expression of PGC-1alpha (show PPARGC1A Antibodies) and SOD2 (show SOD2 Antibodies).

  3. These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis.

  4. NMNAT3 (show NMNAT3 Antibodies) regulates the activity of SIRT3 via synthesis of mitochondria NAD.

  5. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha (show PPARGC1A Antibodies)) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5 (show SIRT5 Antibodies)).

  6. These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 (show UCP2 Antibodies) and SirT3.

  7. despite pre-existing defects in cardiac function and mitochondrial respiratory capacity in SIRT3(-/-) mice, SIRT3 deficiency does not additionally impair cardiac function following myocardial ischemia-reperfusion injury or following myocardial infarction

  8. In the cochlea, the expression of SIRT1 (show SIRT1 Antibodies), 3, and 5 (both mRNA and protein) was decreased in the old mice

  9. SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration.

  10. Results point to an antioxidant defense mechanism presented by Sirt3 through the activation of Foxo3a (show FOXO3 Antibodies), in microglia

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

  1. The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. The expression profile of sirtuin 1 (show SIRT1 Antibodies) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with anti-Sirtuin 3 (SIRT3) Antibodies

  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (sirt3) antibody
  • sirtuin 3 (SIRT3) antibody
  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (SIRT3) antibody
  • sirtuin 3 (Sirt3) antibody
  • 2310003L23Rik antibody
  • AI848213 antibody
  • Sir2l3 antibody
  • sirtuin antibody
  • zgc:158774 antibody

Protein level used designations for anti-Sirtuin 3 (SIRT3) Antibodies

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPECIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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