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Sirtuin 3 Proteins (SIRT3)

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Antibodies (236) and SIRT3 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top SIRT3 Proteins at

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 16 Days

SIRT3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

Top referenced SIRT3 Proteins

  1. Human SIRT3 Protein expressed in Escherichia coli (E. coli) - ABIN667166 : Schwer, North, Frye, Ott, Verdin: The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. in The Journal of cell biology 2002 (PubMed)
    Show all 2 references for ABIN667166

  2. Human SIRT3 Protein expressed in Wheat germ - ABIN1320045 : Pacella-Ince, Zander-Fox, Lan: Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. in Human reproduction (Oxford, England) 2014 (PubMed)

More Proteins for Sirtuin 3 (SIRT3) Interaction Partners

Human Sirtuin 3 (SIRT3) interaction partners

  1. This study underscores an essential role of SIRT3 in the antitumor effect of Bcl-2 (show BCL2 Proteins) inhibitors in human ovarian cancer through regulating both metabolism and apoptosis. The manipulation of Bcl-2 (show BCL2 Proteins) inhibitors combined with the use of classic glycolysis inhibitors may be rational strategies to improve ovarian cancer therapy.

  2. Results elucidated the function of SIRT3 in hepatocellular carcinoma development and suggested that SIRT3 might function as tumor suppressor in hepatocellular carcinoma by targeting PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway.

  3. Dissection of subnetwork architecture led to identification of a fundamental role for SIRT3 in homeostasis of mitochondrial membrane potential. In total, 89 interacting proteins were identified, and extensive validation points to the robustness of the derived network.

  4. SIRT3 overexpression dramatically increased cell viability in a cell model of Parkinson's disease.

  5. Insufficient expression of Sirt3 leads to inefficient mitochondrial biogenesis with decreased developmental competence of human in vitro matured oocytes.

  6. SIRT3 overexpression disrupts mitochondrial proteostasis that causes overproduction of reactive oxygen species and the cell cycle arrest to suppress cell proliferation.

  7. Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Proteins)), endometrial cancer (EC) showed SIRT7 (show SIRT7 Proteins) mRNA overexpression, whereas SIRT1 (show SIRT1 Proteins), SIRT2 (show SIRT2 Proteins), SIRT4 (show SIRT4 Proteins) and SIRT5 (show SIRT5 Proteins) were underexpressed, and no significant differences were observed for SIRT3 and SIRT6 (show SIRT6 Proteins).

  8. microseed matrix seeding (MMS) was used to obtain crystals of human Sirt3 in its apo form and of human Sirt2 in complex with ADP ribose (ADPR).

  9. The results suggest that NRF-2 (show GABPA Proteins) is a regulator of SIRT3 expression and may shed light on how SIRT3 is upregulated during nutrient stress.

  10. Data suggest that DNA sequence variants (DSVs) identified in myocardial infarction (MI) patients may change sirtuin 3 (SIRT3) level by affecting the transcriptional activity of SIRT3 gene promoter, contributing to the MI development as a risk factor.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

  1. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5 (show SIRT5 Proteins)).

  2. These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 (show UCP2 Proteins) and SirT3.

  3. despite pre-existing defects in cardiac function and mitochondrial respiratory capacity in SIRT3(-/-) mice, SIRT3 deficiency does not additionally impair cardiac function following myocardial ischemia-reperfusion injury or following myocardial infarction

  4. In the cochlea, the expression of SIRT1 (show SIRT1 Proteins), 3, and 5 (both mRNA and protein) was decreased in the old mice

  5. SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration.

  6. Results point to an antioxidant defense mechanism presented by Sirt3 through the activation of Foxo3a (show FOXO3 Proteins), in microglia

  7. Sirt3 activation protects the heart from doxorubicin-induced cardiotoxicity by maintaining OGG1 (show OGG1 Proteins) levels and protecting mitochondria from DNA damage.

  8. CerS1 (show CERS1 Proteins), -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice.

  9. as compared to Sirt3 overexpressed and normal groups, the acetylation of IDH2 (show IDH2 Proteins) and accumulation of ox-LDL were significantly higher in the Sirt3 inhibited group

  10. Sirt3-dependent deacetylation of SOD2 (show SOD2 Proteins) plays a protective role against oxidative stress and meiotic defects in oocytes under maternal obese conditions.

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

  1. The results indicate that the variations in the class I sirtuin (show SIRT1 Proteins) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. The expression profile of sirtuin 1 (show SIRT1 Proteins) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with Sirtuin 3 Proteins (SIRT3)

  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (sirt3)
  • sirtuin 3 (SIRT3)
  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (SIRT3)
  • sirtuin 3 (Sirt3)
  • 2310003L23Rik protein
  • AI848213 protein
  • Sir2l3 protein
  • sirtuin protein
  • zgc:158774 protein

Protein level used designations for Sirtuin 3 Proteins (SIRT3)

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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