Sirtuin 3 Proteins (SIRT3)

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping SIRT3 Antibodies (235) and SIRT3 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top SIRT3 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$701.00
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$560.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$364.64
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$656.00
Details
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 11 to 18 Days
$893.75
Details

SIRT3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced SIRT3 Proteins

  1. Human SIRT3 Protein expressed in Wheat germ - ABIN1320045 : Pacella-Ince, Zander-Fox, Lan: Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. in Human reproduction (Oxford, England) 2014 (PubMed)

More Proteins for Sirtuin 3 (SIRT3) Interaction Partners

Human Sirtuin 3 (SIRT3) interaction partners

  1. survival curves showed that higher SIRT3 expression is correlated to a poorer prognosis for patients with grade 3 breast cancer. In conclusion, SIRT3 could be a therapeutic target for breast cancer, improving the effectiveness of CDDP and TAM (show CCNA1 Proteins) treatments.

  2. There were no significant correlations between LRP130, SIRT3, or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130, SIRT3, and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.

  3. In human myometrium, SIRT3 expression decreases with term labor and regulates the mediators involved in the terminal effector pathways of human labor and delivery through the NFkappaB1 pathway.

  4. Mitochondria-targeted esculetin has anti-atherosclerotic effects by inhibiting PAI-1 (show SERPINE1 Proteins) levels by modulating miR (show MLXIP Proteins)-19b and -30c expression and affecting SIRT3- and STAT3 (show STAT3 Proteins)-mediated signaling pathways.

  5. the activation of the SIRT3 axis of the UPRmt is linked to metastasis.

  6. these results suggest a potential relationship between SIRT3 enzymatic activity, IDH2 (show IDH2 Proteins)-K413 acetylation-determined dimerization, and a cancer-permissive phenotype

  7. These data suggest a novel role for SIRT3 deficiency in mediating alveolar epithelial cell mtDNA damage, apoptosis, and lung fibrosis.-

  8. Data suggested a protective role of the SIRT3 single-nucleotide polymorphism rs4980329 in ALS risk.

  9. Low SIRT3 expression is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.

  10. Low SIRT3 expression is associated with Prostate Cancer.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

  1. Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC (show PGC Proteins)-1a-SOD2 (show SOD2 Proteins)-mediated regulation of mitochondrial function

  2. findings reveal an unexpected mechanism for SIRT3 regulation via SIRT1 (show SIRT1 Proteins)-mediated deacetylation. Improving mitochondrial SIRT3 functions by inhibiting SIRT3 acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.

  3. Sirt3 expression in bone marrow cells increases during aging, suggesting that Sirt3 promotes age-related adipogenesis and osteoclastogenesis associated with bone loss. These findings identify Sirt3 as an important regulator of adipogenesis and skeletal homeostasis in vivo and identify Sirt3 as a potential target for the treatment of osteoporosis.

  4. These data suggest a novel role for SIRT3 deficiency in mediating alveolar epithelial cell mtDNA damage, apoptosis, and lung fibrosis.-

  5. Diminished Sirt3 expression and redox inactivation of Sirt3 led to SOD2 (show SOD2 Proteins) inactivation and contributes to hypertension.

  6. Data suggest that negative regulatory effect of Sirt3 on Nlrp3 (show NLRP3 Proteins) inflammasome assembly in macrophages due to prolonged fasting occurs via Sirt3-mediated deacetylation of mitochondrial Sod2 (show SOD2 Proteins), leading to Sod2 (show SOD2 Proteins) activation; prolonged fasting blunts inflammasomes in wild-type mice but not in Sirt3 knock-out mice. (Sirt3 = sirtuin 3; Nlrp3 (show NLRP3 Proteins) = NLR (show CXCR5 Proteins) family, pyrin domain containing 3 protein; Sod2 (show SOD2 Proteins) = superoxide dismutase 2 (show SOD2 Proteins))

  7. Results reveal a potential mechanism by which SIRT3 deletion exacerbates post-MI cardiac dysfunction and impairment of cardiac recovery involving microvascular rarefaction and pre-existing coronary microvascular dysfunction.

  8. expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.

  9. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a (show FOXO3 Proteins)-mediated mitochondria gene expression of PGC-1alpha and SOD2 (show SOD2 Proteins).

  10. These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis.

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

  1. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.

  2. The results indicate that the variations in the class I sirtuin (show SIRT1 Proteins) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  3. The expression profile of sirtuin 1 (show SIRT1 Proteins) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with Sirtuin 3 Proteins (SIRT3)

  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (sirt3)
  • sirtuin 3 (SIRT3)
  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (SIRT3)
  • sirtuin 3 (Sirt3)
  • 2310003L23Rik protein
  • AI848213 protein
  • Sir2l3 protein
  • sirtuin protein
  • zgc:158774 protein

Protein level used designations for Sirtuin 3 Proteins (SIRT3)

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPECIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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