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The protein encoded by SNRPA associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. Additionally we are shipping Small Nuclear Ribonucleoprotein Polypeptide A Proteins (18) and Small Nuclear Ribonucleoprotein Polypeptide A Kits (4) and many more products for this protein.
Showing 10 out of 101 products:
Human Polyclonal SNRPA Primary Antibody for ICC, IF - ABIN4354950
Tanikawa, Sanjiv, Helleday, Herr, Mortusewicz: The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing. in Oncogenesis 2016
Human Monoclonal SNRPA Primary Antibody for IF, WB - ABIN396058
Tresini, Warmerdam, Kolovos, Snijder, Vrouwe, Demmers, van IJcken, Grosveld, Medema, Hoeijmakers, Mullenders, Vermeulen, Marteijn: The core spliceosome as target and effector of non-canonical ATM signalling. in Nature 2015
Cow (Bovine) Polyclonal SNRPA Primary Antibody for IHC, WB - ABIN2778901
Shajani, Varani: 13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. in Journal of molecular biology 2005
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SNRPA Primary Antibody for WB - ABIN2778831
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
p65 (show GORASP1 Antibodies) activation triggered by TCR signaling could promote SNRPA transcription and 3' UTR (show UTS2R Antibodies) shortening of STAT5B (show STAT5B Antibodies). Thus we propose that the alternative polyadenylation switching of STAT5B (show STAT5B Antibodies) induced by TCR activation is mediated by SNRPA.
Data suggest that protein-protein interactions localize U2A' (SNRPA1) to the U2 snRNP (show LSM2 Antibodies) (U2 small nuclear ribonucleoprotein) and exclude it from the U1 snRNP (show LSM2 Antibodies), rather than to enhance U2 snRNA (U2 small nuclear RNA; RNU2-1) binding of U2B'' (SNRPB2 (show SNRPB2 Antibodies)).
a new mechanism for regulating SMN (show STMN1 Antibodies) levels and provides new insight into the roles of U1A in 3' processing of mRNAs.
An analysis of the kinetic data suggests three phases of U1A-SL2 (show MMP10 Antibodies) RNA complex dissociation with time scales of approximately 100 mus (show TRPV6 Antibodies), approximately 50 ms, and approximately 2 s. We propose that the first step of dissociation is a fast rearrangement of the complex to form a loosely bound complex.
structural analysis of U1A protein-stem loop 2 RNA recognition
study shows that the yellow fever virus (YFV) NS5 (show RAF1 Antibodies) protein is able to interact with U1A, a protein involved in splicing and polyadenylation; a region between amino acids 368 and 448 was identified as the site of interaction of the NS5 (show RAF1 Antibodies) protein with U1A
13)C NMR relaxation studies of base and ribose dynamics for the RNA internal loop target of human U1A protein located within the 3'-untranslated region (3'-UTR (show UTS2R Antibodies)) of the mRNA coding for U1A itself
Identification of PSF (show IGFBP7 Antibodies), p54(nrb (show NONO Antibodies)), PTB (show PTBP1 Antibodies), and U1A as proteins specifically bound to the COX-2 (show COX2 Antibodies) polyadenylation signal upstream sequence elements .
Functional U1A site in a cellular gene and of a single gene containing two dissimilar elements that inhibit nuclear polyadenylation.
tissue expression analysis indicated that that swine SDHB (show SDHB Antibodies), SNRPA and CRYBB1 (show CRYBB1 Antibodies) gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver
We found that only the modified U1 snRNA (IVS-AAA (show AAAS Antibodies)) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC (show DDC Antibodies) gene could correct splicing errors of either the mutated human DDC (show DDC Antibodies) minigene or the mouse artificial splicing construct in vitro
Endogenous non-snRNP associated U1A inhibits poly(A) polymerase activity proportional to U1A recovered, suggesting that available U1A level alone is responsible for changes in its inhibitory effect at the secretory IgM poly (A) site.
Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation.
U1 small nuclear ribonucleoprotein A
, U1 snRNP A
, U1 snRNP protein A
, sans fille
, U1 small nuclear RNP-specific A
, U1 snRNP-specific protein A
, protein A of the U1 small nuclear RNA
, U2 small nuclear ribonucleoprotein A'
, small nuclear ribonucleoprotein A
, U2 small nuclear ribonucleoprotein polypeptide A'
, U2 snRNP A'
, U2 snRNP-A'