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K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. Additionally we are shipping Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Proteins (8) and Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Kits (1) and many more products for this protein.
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Human Monoclonal SLC12A5 Primary Antibody for ICC, IF - ABIN1027708
Lee, Walker, Williams, Goodier, Payne, Moss: Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. in The Journal of biological chemistry 2007
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Our network model suggested the loss of KCC2 in a critical number of pyramidal cells increased external potassium and intracellular chloride concentrations leading to seizure-like field potential oscillations. These oscillations included transient discharges leading to ictal-like field events with frequency spectra as in vitro Restoration of KCC2 function suppressed seizure activity and thus may present a useful therapeut
The KCC2 exerts specific functions for the maturation of glycinergic synapses in cultured spinal cord neurons.
SLC12A5 plays a pivotal oncogenic role in colorectal carcinogenesis; its overexpression is an independent prognostic factor of patients with CRC (show CALR Antibodies).
the functional deficit of KCC2 may offer an explanation for the delayed onset of Rett symptoms.
A KCC2 mutation causes epilepsy of infancy with migrating focal seizures. Decreased KCC2 expression, reduced protein glycosylation and impaired Cl- extrusion contribute to loss of KCC2 activity, impairing synaptic inhibition and promoting excitability.
these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1 (show WNK1 Antibodies)-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.
a novel signaling pathway that couples KCC2 to the cytoskeleton and regulates the formation of glutamatergic synapses.
These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE.
KCC2-R952H from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.
Functional characterization of mutant SLC12A5 revealed its potential oncogenic effect in colon cancer.
TGF-beta2 (show TGFB2 Antibodies) is a new regulatory factor for KCC2 functional activation and membrane trafficking.
GABAA (show GABRg1 Antibodies) receptor (GABAAR (show GABRG2 Antibodies)) and the Na(+)-K(+)-2Cl(-) cotransporter (show SLC12A1 Antibodies) (NKCC1 (show SLC12A2 Antibodies)), but not the K(+)-Cl(-) cotransporter (show SLC12A4 Antibodies) (KCC2), were expressed in the terminals of the CRH (show CRH Antibodies) neurons at the median eminence (ME). In contrast, CRH (show CRH Antibodies) neuronal somata were enriched with KCC2 but not with NKCC1 (show SLC12A2 Antibodies).
GluK2 (show GRIK2 Antibodies)-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).
KCC2 expression supersedes NKCC1 (show SLC12A2 Antibodies) in mature fiber cells in mouse and rabbit lenses.
Repeated stress decreased KCC2 expression and increased NKCC1 (show SLC12A2 Antibodies) expression in membranes of granular and pyramidal cells in the hippocampus.
Decreasing [Cl(-)]i levels caused by increasing KCC2 levels in the 12 N could play important roles in regulating the frequency of respiration-related rhythmic activity during development.
Results showed that the fast functional up-regulation of KCC2 in the mouse hippocampus following neonatal status epilepticus is dependent on BDNF (show BDNF Antibodies)
In these neurons, the plasmalemmal expression of KCC2, which establishes the low [Cl(-) ]i required for GABAA R (show GABRG2 Antibodies)-mediated inhibition
Decreased KCC2 protein expression, serine 940 dephosphorylation in motoneurons was found in mice with post-stroke spasticity.
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.
solute carrier family 12 (potassium/chloride transporter), member 5
, K-Cl cotransporter 2
, electroneutral potassium-chloride cotransporter 2
, furosemide-sensitive K-Cl cotransporter
, neuronal K-Cl cotransporter
, neuronal-specific K-Cl cotransporter
, solute carrier family 12 member 5
, solute carrier family 12, member 5
, erythroid K-Cl cotransporter 2