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SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. Additionally we are shipping Speckle-Type POZ Protein Kits (20) and Speckle-Type POZ Protein Proteins (12) and many more products for this protein.
Showing 10 out of 57 products:
Cow (Bovine) Polyclonal SPOP Primary Antibody for WB - ABIN2784150
Bunce, Boronenkov, Anderson: Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. in The Journal of biological chemistry 2008
Dzip1 (show DZIP1 Antibodies)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Antibodies)/Ci proteins in the Hh pathway.
While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse distribution in the nucleus. SPOP oligomerizes through its BTB and BACK domains.
SPOP mutation activates both PI3K (show PIK3CA Antibodies)/mTOR (show FRAP1 Antibodies) and androgen receptor (show AR Antibodies) signaling, effectively uncoupling the normal negative feedback between these two pathways.
SPOP-containing complex regulates SETD2 (show SETD2 Antibodies) stability and H3K36me3-coupled alternative splicing.
The levels of SPOP significantly decreased, while the levels of SIRT2 (show SIRT2 Antibodies) significantly increased in non-small cell lung cancer (NSCLC) cell lines, compared to normal bronchial epithelial cell line and NSCLC specimens, compared to the paired non-tumor lung tissue.
hese findings reveal novel molecular events underlying the regulation of INF2 (show INF2 Antibodies) function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer.
Results show that SPOP is highly expressed in clear cell renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)) and associated with disease progression. In vitro, SPOP promotes the invasiveness of RCC (show XRCC1 Antibodies).
Data indicate that a mutation in the SPOP gene may not be associated with breast cancer, particularly in Chinese women.
SPOP acts as a tumor suppressor by promoting senescence through degrading SENP7 (show SENP7 Antibodies).
our findings emphasize the critical role of SPOP in the regulation of proliferation and migration in liver cancer
results suggest that SPOP plays a pivotal role in colorectal cancer (CRC (show CALR Antibodies)) through mesenchymal-epithelial transition and matrix metalloproteases.
These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.
miR (show MLXIP Antibodies)-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.
similar S/T-rich motifs are present in Gli (show GLI1 Antibodies) proteins as well as in numerous HIB-interacting proteins and mediate Gli (show GLI1 Antibodies) degradation by SPOP
MacroH2A1.2 (show H2AFY Antibodies) binds the nuclear protein Spop.
Interaction of endogenous PDX-1 (show PDX1 Antibodies) and PCIF1 in MIN6 insulinoma (show RPS15 Antibodies) cells, is demonstarted.
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
speckle-type POZ protein
, Speckle-type POZ protein
, speckle-type POZ protein-like
, HIB homolog 1
, speckle-type POZ protein B
, roadkill homolog 1
, PDX-1 C-terminal-interacting factor 1