SPOP-B antibody (AA 48-374) (FITC)
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- Target See all SPOP-B Antibodies
- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
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Binding Specificity
- AA 48-374
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SPOP-B antibody is conjugated to FITC
- Application
- Please inquire
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Speckle-type POZ protein (48-374AA)
- Isotype
- IgG
- Top Product
- Discover our top product SPOP-B Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
- Alternative Name
- SPOP (SPOP-B Products)
- Synonyms
- BTBD32 antibody, TEF2 antibody, AI315626 antibody, Pcif1 antibody, zgc:64140 antibody, spop antibody, tef2 antibody, speckle type BTB/POZ protein antibody, speckle-type POZ protein antibody, speckle type POZ protein S homeolog antibody, SPOP antibody, Spop antibody, spop antibody, spop.S antibody
- Background
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Background: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1, this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.
Aliases: BTBD32 antibody, HIB homolog 1 antibody, Roadkill homolog 1 antibody, Speckle type POZ protein antibody, Speckle-type POZ protein antibody, SPOP antibody, SPOP_HUMAN antibody, TEF 2 antibody, TEF2 antibody
- UniProt
- O43791
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