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Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity).. Additionally we are shipping SOHLH2 Proteins (5) and many more products for this protein.
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Human Polyclonal SOHLH2 Primary Antibody for WB - ABIN2781042
Rual, Venkatesan, Hao, Hirozane-Kishikawa, Dricot, Li, Berriz, Gibbons, Dreze, Ayivi-Guedehoussou, Klitgord, Simon, Boxem, Milstein, Rosenberg, Goldberg, Zhang, Wong, Franklin, Li, Albala, Lim et al.: Towards a proteome-scale map of the human protein-protein interaction network. ... in Nature 2005
Human Polyclonal SOHLH2 Primary Antibody for IF (p), IHC (p) - ABIN1713906
Ding, Wang, Wu, Zhao, Zhang, Li: Protection of Murine Spermatogenesis Against Ionizing Radiation-Induced Testicular Injury by a Green Tea Polyphenol. in Biology of reproduction 2014
The polymorphisms rs1328626 and rs6563386 of the SOHLH2 gene would be the genetic risk factors for nonobstructive azoospermia in the Chinese population. The SNP rs1328641 might influence testes development in the NOA (show DLAT Antibodies) patients.
Low Sohlh2 expression is associated with ovarian cancer.
Our identification of novel variants in the SOHLH2 gene, in women with POF (show POF1B Antibodies) of both Chinese and Serbian origin, strongly suggests an important role for SOHLH2 in human POF (show POF1B Antibodies) etiology.
Sohlh2 may inhibit oocyte apoptosis via c-kit (show KIT Antibodies)/PI3K/Akt (show AKT1 Antibodies)/Foxo3a (show FOXO3 Antibodies) signalling pathway
SOHLH1 (show SOHLH1 Antibodies) and SOHLH2 were able to directly and cooperatively repress STRA8 (show STRA8 Antibodies) expression in cell lines in vitro through binding to its promoter.
Our findings suggest that an SOHLH2/SOHLH1 (show SOHLH1 Antibodies)/SP1 (show SP1 Antibodies) ternary complex autonomously and cooperatively regulates Sohlh1 (show SOHLH1 Antibodies) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.
Effects of BMP4 (show BMP4 Antibodies) on mouse primordial follicle growth were assayed by follicle count and TUNEL labeling. The expression of phospho-SMAD1 (show SMAD1 Antibodies)/5/8, Sohlh2, and c-kit (show KIT Antibodies) were measured by immunohistochemistry, RT-PCR, and Western blotting.
SOHLH1 (show SOHLH1 Antibodies) and SOHLH2 directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression.
Data suggest that a dynamic DNA CpG methylation in Sohlh2 and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons.
SOHLH1 (show SOHLH1 Antibodies) and SOHLH2 suppress genes involved in spermatogonial stem cell maintenance, and induce genes important for spermatogonial differentiation.
The expression pattern of SOHLH2 suggests that it may be a critical regulator of early germ cell development.
Sohlh2 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis
SOHLH2 might coordinate with SOHLH1 (show SOHLH1 Antibodies) to control spermatogonial and oocyte genes, including Sohlh1 (show SOHLH1 Antibodies), to promote the differentiation of KIT(+) germ cells in vivo.
Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity).
spermatogenesis and oogenesis specific basic helix-loop-helix 2
, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2-like
, spermatogenesis associated 28
, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2