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SPHK2 encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Additionally we are shipping Sphingosine Kinase 2 Proteins (7) and Sphingosine Kinase 2 Kits (4) and many more products for this protein.
Showing 10 out of 149 products:
Human Polyclonal SPHK2 Primary Antibody for IHC (p), WB - ABIN391348
Liu, Sugiura, Nava, Edsall, Kono, Poulton, Milstien, Kohama, Spiegel: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. in The Journal of biological chemistry 2000
Show all 8 references for ABIN391348
Human Polyclonal SPHK2 Primary Antibody for EIA, WB - ABIN265069
Zhang, Chung, Oldenburg: A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. in Journal of biomolecular screening 2000
Show all 5 references for ABIN265069
Human Polyclonal SPHK2 Primary Antibody for EIA, IHC (p) - ABIN359440
Xia, Wang, Moretti, Albanese, Chai, Pitson, DAndrea, Gamble, Vadas: Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. in The Journal of biological chemistry 2002
Show all 5 references for ABIN359440
Human Polyclonal SPHK2 Primary Antibody for EIA, IHC (p) - ABIN359441
Shu, Wu, Mosteller, Broek: Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. in Molecular and cellular biology 2002
Show all 4 references for ABIN359441
Human Polyclonal SPHK2 Primary Antibody for IHC (p), WB - ABIN391349
Shutler, Glassco, Kang, Korneluk, Mueller: Genomic structure of the human D-site binding protein (DBP) gene. in Genomics 1996
Show all 4 references for ABIN391349
Human Polyclonal SPHK2 Primary Antibody for EIA, WB - ABIN265189
Okada, Ding, Sonoda, Kajimoto, Haga, Khosrowbeygi, Gao, Miwa, Jahangeer, Nakamura: Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis. in The Journal of biological chemistry 2005
Sk1 (show SPHK1 Antibodies) and Sk2 (show KCNN2 Antibodies) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 and dihydroceramide desaturase (show DEGS1 Antibodies).
increased SK and SPL (show SGPL1 Antibodies) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
Because of the unique relationship observed after serum depletion, we examined effects of siRNA for SPHK2, and found the role of SPHK2 as a growth or survival factor but not a cell proliferation inhibitor in FCS(-) culture
Targeting of SphK2 by ABC294640 potently inhibits colorectal cancer cell growth both in vitro and in vivo.
results define new mechanistic insights for EGF (show EGF Antibodies)-mediated invasion and novel actions of SK2 (show KCNN2 Antibodies)
These data illuminate a novel survival mechanism and potential therapeutic target for KSHV-infected endothelial cells: SphK2-associated maintenance of viral latency
Down-regulation of SphK2 increased the effects of all-trans-retinoic acid on colon cancer cells.
SphK2 plays a controversial role in arthritis.
IGF1R (show IGF1R Antibodies) mediates insulin (show INS Antibodies)-stimulated phosphorylation of both SphK1 (show SPHK1 Antibodies) and SphK2.
Data show that sphingosine kinase SphK1 (show SPHK1 Antibodies) and sphingosine-1-phosphate (S1P (show MBTPS1 Antibodies)) receptors S1P1 (show S1PR1 Antibodies), S1P2 (show S1PR2 Antibodies), S1P3 (show S1PR3 Antibodies), and S1P5 (show S1PR5 Antibodies) were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 levels were highest in primary tumors.
Results show that Sphk2/S1P (show S1PR1 Antibodies) has an important role to play in the survival of the dopaminergic neurons, in the pathogenesis of Parkinson's disease
Demonstrate that Sphk2 is the major Sphk (show SPHK1 Antibodies) isoform responsible for the generation of S1P (show S1PR1 Antibodies) in platelets and plays a pivotal intrinsic role in the control of platelet activation.
transcriptionally up-regulated by acute endoplasmic reticulum stress through activation of ATF4 (show ATF4 Antibodies) and improves perturbed hepatic glucose and fatty acid metabolism
These results strongly indicate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disrupting the Beclin 1 (show BECN1 Antibodies)/Bcl-2 (show BCL2 Antibodies) interaction.
SK1 (show SPHK1 Antibodies) and SK2 (show PAPSS2 Antibodies) down-regulation reduces the motility of satellite cells.
attenuation of Sphk1 (show SPHK1 Antibodies), 2 activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.
Sphk2 provides the source of intracellular S1P (show S1PR1 Antibodies) that controls thrombopoiesis, which is associated with Src (show SRC Antibodies) family kinases expression and activity in megakaryocytes.
sphingosine kinase-2 has a role in a murine model of lupus nephritis
The function of SphK1 (show SPHK1 Antibodies) and SphK2 can be interchangeable in mast cells and is species and cell type determined.
Applying genetic and pharmacological approaches, we demonstrate that neuronal SPK2 isoform plays an important role in cerebral preconditioning.
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, sphingosine kinase 2
, sphingosine kinase
, sphingosine kinase II
, sphingosine kinase 2-like
, sphingosine kinase type 2
, SK 2
, SPK 2
, Spk2, Sk2