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Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. Additionally we are shipping SHB Antibodies (56) and many more products for this protein.
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Shb binds to tyrosine 1175 in the VEGFR-2 (show KDR Proteins), which regulates VEGF (show VEGFA Proteins)-induced formation of focal adhesions and cell migration, of which the latter occurs in a phosphatidylinositol 3-kinase-dependent manner [shb]
SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types. [review]
SH2-Bbeta is a Rac (show AKT1 Proteins)-binding protein that regulates cell motility
Shb links SLP-76 (show LCP2 Proteins) and Vav (show VAV1 Proteins) with the CD3 (show CD3 Proteins) complex in Jurkat T cells (SLP-76 (show LCP2 Proteins))
SHB links IL2 (show IL2 Proteins) receptor for signal transduction and mediates apoptosis
Taken together, our results suggest that SH2-Bbeta is a new signaling molecule involved in GDNF (show GDNF Proteins)-induced neurite outgrowth.
It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 (show PDX1 Proteins) and insulin (show INS Proteins) in EBs and that such cells can be separated by FACS.
The observed aberrations in myeloid cell properties in Shb-deficient mice are likely consequences of an abnormal vascular compartment and are not responsible for reduced muscle blood flow
a unique combinatorial response of increased vascular permeability and reduced recruitment of cytotoxic CD8 (show CD8A Proteins)+ cells occurs as a consequence of Shb deficiency in B16F10 melanomas.
Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.
Data suggest that absence of Src homology-2 protein Shb accelerates disease progression by exerting dual roles in BCR-ABL-induced leukemia: increased cell expansion due to elevated focal adhesion kinase (FAK) activity and neutrophilia in peripheral blood.
loss of Shb alters TCR signalling ability, thereby favouring the development of Th2-driven inflammation and exacerbating symptoms of allergy
Shb knockout mouse exhibited structural and functional (angiogenesis and vascular permeability) vascular abnormalities that have implications for understanding the function of VEGF-A (show VEGFA Proteins) under physiological conditions
Data show reduced VEGF-A (show VEGFA Proteins) expression in Shb-deficient tumors.Interference with Shb signaling may provide novel means for future cancer therapy.
Shb appears to play an important modulating role on T- Cell receptor signaling, thus regulating the peripheral CD4 (show CD4 Proteins)+ T(H)2 cell response.
It is concluded that SHB regulates normal oocyte and follicle development and that perturbation of SHB signaling causes defective meiosis I and early embryo development
Shb binds directly to FAK (show PTK2 Proteins) and regulates its phosphorylation leading to enhanced cell spreading in a Src (show SRC Proteins)-dependent manner.
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Src homology 2 domain containing adaptor protein B
, SH2 domain-containing adapter protein B-like
, SH2 domain-containing adapter protein B
, SHB (Src homology 2 domain containing) adaptor protein B
, SHB adaptor protein (a Src homology 2 protein)