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Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Proteins (11) and Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Kits (4) and many more products for this protein.
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Human Polyclonal SDHB Primary Antibody for IHC, IHC (p) - ABIN4352356
van Nederveen, Gaal, Favier, Korpershoek, Oldenburg, de Bruyn, Sleddens, Derkx, Rivière, Dannenberg, Petri, Komminoth, Pacak, Hop, Pollard, Mannelli, Bayley, Perren, Niemann, Verhofstad, de Bruïne et al.: An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. ... in The Lancet. Oncology 2009
Show all 15 references for ABIN4352356
Human Polyclonal SDHB Primary Antibody for WB - ABIN1881781
Cerecer-Gil, Figuera, Llamas, Lara, Escamilla, Ramos, Estrada, Hussain, Gaal, Korpershoek, de Krijger, Dinjens, Devilee, Bayley: Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2010
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Human Polyclonal SDHB Primary Antibody for ICC, IF - ABIN4352351
Morton, Beltram, Carter, Michailidou, Gorjanc, McFadden, Barrios-Llerena, Rodriguez-Cuenca, Gibbins, Aird, Moreno-Navarrete, Munger, Svenson, Gastaldello, Ramage, Naredo, Zeyda, Wang, Howie, Saari et al.: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. ... in Nature medicine 2016
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Human Polyclonal SDHB Primary Antibody for ELISA, WB - ABIN185447
Selak, Armour, MacKenzie, Boulahbel, Watson, Mansfield, Pan, Simon, Thompson, Gottlieb: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. in Cancer cell 2005
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Cow (Bovine) Polyclonal SDHB Primary Antibody for WB - ABIN2783181
Cascón, Landa, López-Jiménez, Díez-Hernández, Buchta, Montero-Conde, Leskelä, Leandro-García, Letón, Rodríguez-Antona, Eng, Neumann, Robledo: Molecular characterisation of a common SDHB deletion in paraganglioma patients. in Journal of medical genetics 2008
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sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome
According to international guidelines, SDHB, SDHC (show SDHC Antibodies), and SDHD (show SDHD Antibodies) genetic testing were performed in this patient, but not SDHA (show SDHA Antibodies), which would have been prescribed only after surgery, in case of SDHA (show SDHA Antibodies) negative immunohistochemistry
that SDHAF1 (show SDHAF1 Antibodies) contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB.
The low penetrance of SDHB mutations may obscure the hereditary nature of SDHB-linked disease and is important in the counseling of SDHB-linked patients.
Succinate dehydrogenase (show SDHA Antibodies) deficiency is a rare leukoencephalopathy, for which improved recognition by magnetic resonance imaging (MRI (show C7ORF49 Antibodies)) in combination with advanced sequencing technologies allows noninvasive diagnostic confirmation.
15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB and SDHD (show SDHD Antibodies) mutations
Study reveals new insights into the effects of SDHB mutations and the power of structural modelling in predicting biological consequences.
for the first time, we show a high correlation between urinary bladder paragangliomas and SDHB mutations
Findings provide a conceptual framework for understanding how particular mutations disproportionately cause the loss of SDH (show SARDH Antibodies) activity, resulting in accumulation of succinate and metabolic remodeling in SDHB cancer syndromes.
Germline mutation in the SDHB gene is the only reliable predictor of malignant Paragangliomas.
Report direct correlation between the presence of an SDHB mutation, whether germline or somatic, and negative SDHB immunohistochemical staining in bladder paragangliomas.
tissue expression analysis indicated that that swine SDHB, SNRPA (show SNRPA Antibodies) and CRYBB1 (show CRYBB1 Antibodies) gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver
Data show that lack of succinate dehydrogenase (SDH (show SDHA Antibodies)) activity commits cells to consume extracellular pyruvate.
Using Sdhb(+/-) mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to pituitary adenoma formation.
Tumor-derived FH and SDH (show SDS Antibodies) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Antibodies).
Data show that two subunits of complex II (succinate dehydrogenase (show SDHD Antibodies), or SDH (show SDS Antibodies)), SDHA (show SDHA Antibodies) and SDHB, interacted specifically with SIRT3 (show SIRT3 Antibodies).
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
, succinate dehydrogenase complex subunit B
, COMPLEX II: iron-sulfur subunit
, iron-sulfur protein subunit of succinate dehydrogenase
, succinate dehydrogenase
, succinate dehydrogenase B
, succinate dehydrogenase Iron-sulfur
, succinate dehydrogenase Iron-sulfur protein
, succinate dehydrogenase iron protein
, succinate dehydrogenase subunit b
, iron-sulfur subunit of complex II
, Iron-sulfur subunit of complex II