anti-TATA Box Binding Protein (TBP) Antibodies

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. Additionally we are shipping TBP Proteins (35) and TBP Kits (25) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TBP 6908 P20226
TBP 21374 P29037
TBP 117526  
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Top anti-TBP Antibodies at antibodies-online.com

Showing 10 out of 143 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-TBP Antibody Titration: </b>2.5ug/ml<br><b>Positive Control: </b>Human Placenta 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells, using TBP Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of TBP antibody (C-term) (ABIN390630) in HL60 cell line lysates (35 µg/lane). TBP (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with TBP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of TBP antibody (Center) (ABIN390631) in HL60 cell line lysates (35 µg/lane). TBP (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with TBP Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Chicken Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of TBP staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of TBP staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of TBP antibody (C-term) in HL60 cell line lysates (35ug/lane). TBP (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ICC, IF, IP, IHC, WB Tbp antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with Tbp antibody at a 0.5 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details

TBP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TBP Antibodies

  1. Human Monoclonal TBP Primary Antibody for WB - ABIN1882281 : Hoffman, Sinn, Yamamoto, Wang, Roy, Horikoshi, Roeder: Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID). in Nature 1990 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal TBP Primary Antibody for WB - ABIN1882282 : Peterson, Tanese, Pugh, Tjian: Functional domains and upstream activation properties of cloned human TATA binding protein. in Science (New York, N.Y.) 1990 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal TBP Primary Antibody for ICC, IF - ABIN2668630 : Brou, Chaudhary, Davidson, Lutz, Wu, Egly, Tora, Chambon: Distinct TFIID complexes mediate the effect of different transcriptional activators. in The EMBO journal 1993 (PubMed)
    Show all 3 Pubmed References

  4. Cow (Bovine) Polyclonal TBP Primary Antibody for WB - ABIN2792684 : Reid, van Roon-Mom, Wood, Rees, Owen, Faull, Dragunow, Snell: TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease. in Brain research. Molecular brain research 2004 (PubMed)
    Show all 2 Pubmed References

More Antibodies against TBP Interaction Partners

Fruit Fly (Drosophila melanogaster) TATA Box Binding Protein (TBP) interaction partners

  1. Results indicate that a portion of Brf1 is sandwiched between Bdp1 and TBP upstream of the U6 TATA box. Furthermore, Bdp1 traverses the DNA under the N-terminal stirrup of TBP to interact with the DNA (and very likely Brf1) downstream of the TATA sequence.

  2. TFIID (show TAF8 Antibodies) has two disctinct modes of transcription initiation, de novo initiation and reinitiation, as revealed by the inhibitory effect of TFIID (show TAF8 Antibodies)-bound tin (show MSH2 Antibodies) compounds on the de novo initiation, but not on the reinitiation.

  3. Deactivation of TBP contributes to SCA17 pathogenesis.

  4. Aptamers generated by both selections were able to bind specifically to TBP, but the two groups showed characteristics which were clearly different in terms of their capability to compete with TATA-DNA.

  5. in fruit flies, different classes of RNA polymerase III promoters differentially utilize TBP and TRF1 (show TERF1 Antibodies) for the initiation of transcription.

  6. Tbp targets core histone transcription.

  7. TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 (show BTAF1 Antibodies) and NC2 (show GTF2H5 Antibodies) block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription.

Human TATA Box Binding Protein (TBP) interaction partners

  1. Data indicate the crystal structure of a Brf2 (show ZFP36L2 Antibodies)-TBP-Bdp1 (show PTPN18 Antibodies) complex bound to a DNA promoter.

  2. Study could not determine a definitive cutoff value for the pathologic CAG repeat (show CELF3 Antibodies) number of SCA17.

  3. TBP attenuates Msx1 (show MSX1 Antibodies)-mediated glycoprotein hormone alpha (show CGA Antibodies) transcriptional repression.

  4. this analysis of the 2.2-kb doubly spliced RNA (2.2DS-RNA) -mediated suppression of viral RNA expression showed that 2.2DS-RNA inhibited transcription via binding to the TATA-binding protein and stress granule proteins.

  5. Our results provide first evidence that Taspase1 processing affects TFIIA (show GTF2A1 Antibodies) regulation of TFIID and suggest that Taspase1 processing of TFIIA (show GTF2A1 Antibodies) is required to establish INR (show INSR Antibodies)-selective core promoter activity in the presence of NC2 (show GTF2H5 Antibodies).

  6. TBP (and GATA2 (show GATA2 Antibodies) and Sp1 (show PSG1 Antibodies)) have key roles in inflammation and ischemia-like conditions through MAOA (show MAOA Antibodies) regulation.

  7. Deactivation of TBP contributes to SCA17 pathogenesis.

  8. HOXA2 (show HOXA2 Antibodies) acts as a suppressor or TBP-antagonist to inhibit MMP-9 (show MMP9 Antibodies) expression; while methylation-mediated inactivation of HOXA2 (show HOXA2 Antibodies) in NPC (show NPC1 Antibodies) derepresses MMP-9 (show MMP9 Antibodies) production and increases invasion of NPC (show NPC1 Antibodies) cells.

  9. The data reveal synergistic effects of H3K4me3, H3K14ac and a TATA box sequence on TFIID binding in vitro. Stoichiometry analyses of affinity purified human TFIID identified the presence of a stable dimeric core.

  10. The UL4 protein directly interacted with the host TBP and the carboxy-terminal domain of RNA polymerase II in infected cells.

Zebrafish TATA Box Binding Protein (TBP) interaction partners

  1. TBP plays an important role in the degradation of a specific subset of maternal mRNAs during late blastulation/early gastrulation, which involves targets of the miR (show MYLIP Antibodies)-430 pathway.

Mouse (Murine) TATA Box Binding Protein (TBP) interaction partners

  1. the TAF10-containing canonical TFIID and SAGA complexes are dispensable for early paraxial mesoderm development, arguing against the generic role in transcription proposed for these fully assembled holo-complexes

  2. Our study establishes glial dysfunction as an important component of SCA17 pathogenesis and suggests targeting glial inflammation as a potential therapeutic approach for SCA17 treatment.

  3. This evidence demonstrates that TBP2 (show Tbpl2 Antibodies) does not replace TBP during muscle differentiation, as previously proposed, with limiting amounts of TFIID-TBP being required to promote muscle-specific (show EIF3K Antibodies) gene expression

  4. The large TBP polyQ repeat decreases the association of MyoD with TBP and DNA promoters and causes muscle degeneration in spinocerebellar ataxia 17 transgenic mice.

  5. Thus, modulating the levels of both Huwe1 and USP10 (show USP10 Antibodies) appears to fine-tune the requisite degradation of TBP during myogenesis.

  6. This study demonistrated that denervation-induced muscle atrophy on Tbp expression in mice.

  7. The results of this study confirmed motor deficits in the Tbp/Q71 mice and present previously unrecognized behavioral characteristics obtained from the automated home cage, indicating its use for high-throughput screening and testing.

  8. TBP might be a marker for transmitting cellular memory to daughter cells.

  9. we show that the differentiation of fetal liver progenitors to adult hepatocytes involves a wholesale depletion of canonical cofactor required for Sp1 activation/Mediator and TFIID complexes at both the RNA and protein level

  10. Alcohol induces RNA polymerase III-dependent transcription through c-Jun (show JUN Antibodies) by co-regulating TATA-binding protein (TBP) and Brf1 (show ZFP36L1 Antibodies) expression.

TBP Antigen Profile

Protein Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TBP

  • TATA binding protein (Tbp) antibody
  • TATA box binding protein (TBP) antibody
  • TATA box binding protein (tbp) antibody
  • TATA box binding protein (tbp-a) antibody
  • TATA box binding protein (Tbp) antibody
  • TATA-box-binding protein (Tbp) antibody
  • CG9874 antibody
  • Dmel\\CG9874 antibody
  • dtbp antibody
  • dTFIID antibody
  • fd20h06 antibody
  • Gtf2d antibody
  • gtf2d1 antibody
  • HDL4 antibody
  • RBP antibody
  • sca17 antibody
  • si:zc101n13.2 antibody
  • tbp antibody
  • TBP1 antibody
  • TBP38 antibody
  • tfiid antibody
  • tfiidtau antibody
  • wu:fd20h06 antibody
  • xtbp antibody
  • zgc:66213 antibody

Protein level used designations for TBP

42kDa polypeptide , CG9874-PA , TATA box binding protein , TATA box-binding protein , TATA-binding protein , TATA-box binding protein , Tbp-PA , TATA binding protein , TATA-box-binding protein , TATA sequence-binding protein , TATA-box binding protein N-terminal domain , TATA-box factor , transcription initiation factor TFIID TBP subunit , TATA-binding factor , zTBP , zfTBF , transcription factor , TA-TA binding protein 1 , TFIID core protein , Transcription initiation factor TFIID TBP subunit

GENE ID SPECIES
37476 Drosophila melanogaster
431689 Canis lupus familiaris
696258 Macaca mulatta
738472 Pan troglodytes
100101451 Takifugu rubripes
100380389 Salmo salar
6908 Homo sapiens
368882 Danio rerio
399465 Xenopus laevis
395995 Gallus gallus
611193 Canis lupus familiaris
516578 Bos taurus
21374 Mus musculus
117526 Rattus norvegicus
100144760 Ovis aries
780434 Sus scrofa
101839769 Mesocricetus auratus
692612 Bombyx mori
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