anti-TYRO Protein tyrosine Kinase Binding Protein (TYROBP) Antibodies

TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. Additionally we are shipping TYROBP Kits (11) and TYROBP Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TYROBP 361537 Q6X9T7
TYROBP 7305 O43914
TYROBP 22177 O54885
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Top anti-TYROBP Antibodies at antibodies-online.com

Showing 10 out of 98 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB TYROBP Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. TYROBP Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TYROBP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: DAP12 Antibody [NBP1-85313] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY403671) Immunohistochemistry-Paraffin: DAP12 Antibody [NBP1-85313] - Staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of TYROBP Antibody (C-term) (ABIN653819) in HepG2 cell line lysates (35 µg/lane). TYROBP (arrow) was detected using the purified polyclonal antibody. TYROBP Antibody (C-term) (ABIN653819) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$304.50
Details
Bat Goat Un-conjugated IHC (p), ELISA Human Spleen (formalin-fixed, paraffin-embedded) stained with TYROBP antibody ABIN462404 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Uterus (formalin-fixed, paraffin-embedded) stained with TYROBP antibody ABIN462404 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: DAP12 Antibody [NBP2-16099] - Western Blot analysis of TYROBP expression in transfected 293T cell line by TYROBP polyclonal antibody. A: Non-transfected lysate. B: TYROBP transfected lysate. 15% SDS PAGE gel, diluted at 1:500. Immunohistochemistry-Paraffin: DAP12 Antibody [NBP2-16099] - Immunohistochemical analysis of paraffin-embedded H1299 xenograft, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Goat Un-conjugated EIA, IHC (p) Human Spleen (formalin-fixed, paraffin-embedded) stained with TYROBPfollowed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Uterus (formalin-fixed, paraffin-embedded) stained with TYROBPfollowed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Mouse PE FACS Detection of DAP12 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$320.25
Details

TYROBP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TYROBP Antibodies

  1. Human Polyclonal TYROBP Primary Antibody for EIA, FACS - ABIN955408 : Chen, Bai, Sokol, Zhou, Ren, Painter, Liu, Sallman, Chen, Yoder, Djeu, Loughran, Epling-Burnette, Wei: A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. in Blood 2009 (PubMed)
    Show all 3 references for 955408

  2. Human Polyclonal TYROBP Primary Antibody for IP, WB - ABIN265057 : Lanier, Bakker: The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. in Immunology today 2001 (PubMed)
    Show all 2 references for 265057

  3. Human Polyclonal TYROBP Primary Antibody for IHC, IHC (p) - ABIN4304256 : Preusse, Goebel, Pehl, Rinnenthal, Kley, Allenbach, Heppner, Vorgerd, Authier, Gherardi, Stenzel: Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis. in Neuropathology and applied neurobiology 2015 (PubMed)

More Antibodies against TYROBP Interaction Partners

Zebrafish TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. The structure of the adaptor protein dap12 has been identified in the zebrafish genome.

  2. DAP12-based activating pathway is conserved between bony fish and mammals

Human TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. TYROBP/CSTA (show CSTA Antibodies) gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis

  2. The different expression of DAP12 compared to TREM2 (show TREM2 Antibodies) represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia.

  3. the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1 (show CSF1 Antibodies)-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation

  4. Impaired signaling by the TREM2 (show TREM2 Antibodies)-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review.

  5. T cells modified to express a KIR (show GEM Antibodies)-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta (show CD247 Antibodies)-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy.

  6. This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation.

  7. isolated PMNs have an increased proportion of both TREM1 (show TREM1 Antibodies) and DAP12 compared to normal healthy control

  8. results support a role of DAP12 in stabilizing TREM2 (show TREM2 Antibodies)-CTF (show NFIA Antibodies), thereby protecting against excessive pro-inflammatory responses.

  9. Data indicate that NKG2 receptor NKG2E (show KLRC3 Antibodies) was capable of associating with CD94 (show KLRD1 Antibodies) and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum.

  10. Macrophage traits in BRC cells facilitate the metastatic process and DAP12 expression might promote metastatic homing to bone and liver tissues.

Mouse (Murine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 (show TREM2 Antibodies) and DAP12, both of which are expressed by microglia and have bee

  2. TNF (show TNF Antibodies)/IL-6 (show IL6 Antibodies) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Antibodies), DNAX-activation protein 12, and cell proliferation.

  3. The findings suggest that DAP12 acts as a brake on the pulmonary immune response to C. neoformans by promoting pulmonary eosinophilia and by inhibiting the activation and antifungal activities of effector cells, including NK cells and macrophages.

  4. significant role of DAP12 in the initial inflammatory response, bone remodeling and regeneration

  5. DAP12-mediated microglial activation following axotomy promotes pro-inflammatory responses, and thereby accelerates nerve injury-induced neuron death

  6. results support a role of DAP12 in stabilizing TREM2 (show TREM2 Antibodies)-CTF (show NFIA Antibodies), thereby protecting against excessive pro-inflammatory responses.

  7. a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.

  8. DAP12 expression in liver grafts regulates donor mDC (show ADAM11 Antibodies) migration to host lymphoid tissue, alloreactive T cell responses and transplant tolerance

  9. Integrin alphav beta3/Dap12 double-deficient developed profound osteoporosis.

  10. Our study identifies the DAP12/IRAK-M (show IRAK3 Antibodies)/IL-10 (show IL10 Antibodies) to be a novel molecular pathway in APCs (show APCS Antibodies) exploited by mycobacterial pathogens, allowing infection a foothold in the lung.

Cow (Bovine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

TYROBP Antigen Profile

Protein Summary

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with TYROBP

  • TYRO protein tyrosine kinase binding protein (TYROBP) antibody
  • TYRO protein tyrosine kinase binding protein (tyrobp) antibody
  • Tyro protein tyrosine kinase binding protein (Tyrobp) antibody
  • TYRO protein tyrosine kinase binding protein (Tyrobp) antibody
  • dap12 antibody
  • KARAP antibody
  • Ly83 antibody
  • PLOSL antibody
  • TYROBP antibody
  • tyrpbp antibody

Protein level used designations for TYROBP

TYRO protein tyrosine kinase-binding protein , TYRO protein tyrosine kinase binding protein , DAP12 protein , dap12 , DAP12 , DNAX-activation protein 12 , killer cell activating receptor-associated protein , KAR-associated protein , killer activating receptor associated protein , killer-activating receptor-associated protein , killer cell activating receptor associated protein , immunoreceptor DAP12 , tyrosine kinase binding protein

GENE ID SPECIES
476477 Canis lupus familiaris
443208 Ovis aries
100101461 Danio rerio
361537 Rattus norvegicus
7305 Homo sapiens
22177 Mus musculus
282390 Bos taurus
397405 Sus scrofa
574207 Macaca mulatta
455968 Pan troglodytes
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