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TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Additionally we are shipping TREM2 Antibodies (134) and TREM2 Kits (13) and many more products for this protein.
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Mouse (Murine) TREM2 Protein expressed in Human Cells - ABIN2007409
Bouchon, Dietrich, Colonna: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. in Journal of immunology (Baltimore, Md. : 1950) 2000
Show all 2 references for ABIN2007409
Human TREM2 Protein expressed in Human Cells - ABIN2003942
Paloneva, Manninen, Christman, Hovanes, Mandelin, Adolfsson, Bianchin, Bird, Miranda, Salmaggi, Tranebjaerg, Konttinen, Peltonen: Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. in American journal of human genetics 2002
Show all 2 references for ABIN2003942
the minor T allele at TREM2 (p.R47H, rs75932628) showed nominally significant association with AD risk (OR 5 5.73, 95% CI 5 1.80-18.25, P 5 .0232), whereas no significant association for risk of frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease.
study to determine soluble TREM-1 (show TREM1 Proteins) and TREM-2 levels in serum, and membrane-bound TREM-1 (show TREM1 Proteins) and TREM-2 on peripheral blood mononuclear cells of patients with pulmonary TB
Report altered TREM-1 (show TREM1 Proteins)/TREM-2 ratio in cutaneous melanoma.
miRNA-34a-mediated modulation of TREM2 may in part regulate the phagocytic response
The selective expression of TREM2 on myeloid cells and microglia and its association with different forms of dementia indicate a contribution of TREM2 and mutations in TREM2 in common pathways of neurodegeneration. [REVIEW]
Genome-wide association studies have identified variants of the gene that encodes triggering receptor expressed on myeloid cells 2 (TREM2) as risk factors for non-familial Alzheimer disease (AD).
neither variant rs75932628 nor rs2234253 be a major susceptibility factor of sporadic Parkinson disease in Chinese Han population from Mainland China.
The TREM2 rs75932628 is unlikely to play a major role in the pathogenesis of Parkinson's disease and multiple system atrophy.
Meta-analysis demonstrates that TREM2 is a candidate gene for Alzheimer's disease susceptibility, and TREM2 variant rs75932628 may be a risk factor for Alzheimer's disease
The different expression of DAP12 (show TYROBP Proteins) compared to TREM2 represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia.
TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology.
TREM2 is involved in prion (show PRNP Proteins)-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion (show PRNP Proteins) infections.
These findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages.
TREM-1 (show TREM1 Proteins)/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role.
These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage
TREM-2 has a protective effect on inflammatory response of endotoxin-induced acute lung injury in mice.
results support a role of DAP12 (show TYROBP Proteins) in stabilizing TREM2-CTF (show NFIA Proteins), thereby protecting against excessive pro-inflammatory responses.
Corpus callosum microglia normally expand with age, but aged Trem2(-/-) mice had fewer microglia with an abnormal morphology which failed to amplify transcripts indicative of activation, phagocytosis, and lipid catabolism in response to myelin damage.
Data (including data from studies using knockout mice) suggest that TREM2 is expressed on alveolar macrophages and lung mucosa and plays role innate immunity during pneumococcal pneumonia; knockout of TREM2 increases phagocytosis and survival.
viral replication increases lung macrophage levels of intracellular and cell surface TREM-2, and this action prevents macrophage apoptosis
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
triggering receptor expressed on myeloid cells 2
, triggering receptor expressed on monocytes 2
, triggering receptor expressed on myeloid cells 2a
, triggering receptor expressed on myeloid cells 2b
, triggering receptor expressed on myeloid cells 2c