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Triggering Receptor Expressed On Myeloid Cells 2 Proteins (TREM2)

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Additionally we are shipping TREM2 Antibodies (176) and TREM2 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Top TREM2 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Mammalian Cells Mouse Fc Tag   50 μg Log in to see 5 Days
$329.18
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$413.21
Details
HOST_Escherichia coli (E. coli) Mouse GST tag,His tag   100 μg Log in to see 11 to 13 Days
$774.40
Details

TREM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) , , ,
, , ,
Rat (Rattus)

Top referenced TREM2 Proteins

  1. Mouse (Murine) TREM2 Protein expressed in Human Cells - ABIN2007409 : Bouchon, Dietrich, Colonna: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. in Journal of immunology (Baltimore, Md. : 1950) 2000 (PubMed)
    Show all 2 references for ABIN2007409

  2. Human TREM2 Protein expressed in Human Cells - ABIN2003942 : Paloneva, Manninen, Christman, Hovanes, Mandelin, Adolfsson, Bianchin, Bird, Miranda, Salmaggi, Tranebjaerg, Konttinen, Peltonen: Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. in American journal of human genetics 2002 (PubMed)
    Show all 2 references for ABIN2003942

More Proteins for Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Interaction Partners

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. silencing TREM-2 downregulated the expression levels of Bcl2 (show BCL2 Proteins) and PCNA (show PCNA Proteins), and upregulated the expression levels of Bax (show BAX Proteins) and caspase-3 (show CASP3 Proteins) in renal cell carcinoma (show MOK Proteins) cells. Depletion of TREM-2 inactivated PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway through increasing the expression of PTEN. TREM-2 acts as an oncogene (show RAB1A Proteins) in the development of renal cell carcinoma (show MOK Proteins) and can be considered as a novel therapeutic factor in the treatment of renal cell carcinoma (show MOK Proteins).

  2. TREM2 expression is significantly upregulated in human masticatory mucosa during wound healing

  3. this study shows that activation of TREM-2 may restrain h-MSC (show MSC Proteins) immune activation and promote differentiation for tissue repair

  4. The TREM family members are also considered to involve in Alzheimer's disease (AD) and cerebrospinal fluid (CSF (show CSF2 Proteins)) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease.

  5. Study provides evidence that TREM2 mRNA is upregulated in the human hippocampus affected by Alzheimer's disease (AD). Findings also suggest that 5hmC may play a role in regulating TREM2 mRNA expression in AD hippocampus.

  6. The study suggests that TREM2 may work as an oncogene (show RAB1A Proteins) and a new effective therapeutic target for glioma treatment.

  7. CSF (show CSF2 Proteins) concentrations of soluble TREM2 are higher in Alzheimer's disease than in controls

  8. Variant p.R47H of TREM2 was not associated with Parkinson's disease

  9. Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for leucoaraiosis or Parkinson's disease in the Han Chinese population.

  10. the minor T allele at TREM2 (p.R47H, rs75932628) showed nominally significant association with AD risk (OR 5 5.73, 95% CI 5 1.80-18.25, P 5 .0232), whereas no significant association for risk of frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. This study showed that TREM-2 deficiency restricts the inflammatory response, thereby decreasing organ damage and mortality.

  2. TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology.

  3. TREM2 is involved in prion (show PRNP Proteins)-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion (show PRNP Proteins) infections.

  4. These findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages.

  5. TREM-1 (show TREM1 Proteins)/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role.

  6. These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage

  7. TREM-2 has a protective effect on inflammatory response of endotoxin-induced acute lung injury in mice.

  8. results support a role of DAP12 (show TYROBP Proteins) in stabilizing TREM2-CTF (show NFIA Proteins), thereby protecting against excessive pro-inflammatory responses.

  9. Corpus callosum microglia normally expand with age, but aged Trem2(-/-) mice had fewer microglia with an abnormal morphology which failed to amplify transcripts indicative of activation, phagocytosis, and lipid catabolism in response to myelin damage.

  10. Data (including data from studies using knockout mice) suggest that TREM2 is expressed on alveolar macrophages and lung mucosa and plays role innate immunity during pneumococcal pneumonia; knockout of TREM2 increases phagocytosis and survival.

TREM2 Protein Profile

Protein Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2)
  • triggering receptor expressed on myeloid cells 2 (trem2)
  • triggering receptor expressed on myeloid cells 2 (LOC100228399)
  • triggering receptor expressed on myeloid cells 2 (Trem2)
  • TREM-2 protein
  • TREM-A1 protein
  • TREM-B1 protein
  • TREM2 protein
  • Trem2a protein
  • Trem2b protein
  • Trem2c protein

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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