You are viewing an incomplete version of our website. Please click to reload the website as full version.

Tryptophan 2,3-Dioxygenase Proteins (TDO2)

TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Additionally we are shipping Tryptophan 2,3-Dioxygenase Antibodies (49) and Tryptophan 2,3-Dioxygenase Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TDO2 6999 P48775
TDO2 56720 P48776
TDO2 64206 P21643
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Tryptophan 2,3-Dioxygenase Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 0.05 mg Log in to see 2 to 3 Days
$343.75
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mosquito His tag   50 μg Log in to see 5 to 8 Days
$488.25
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,125.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,125.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,125.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$364.64
Details

TDO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Tryptophan 2,3-Dioxygenase Proteins

  1. Human TDO2 Protein expressed in Escherichia coli (E. coli) - ABIN667369 : Murray: The human indoleamine 2,3-dioxygenase gene and related human genes. in Current drug metabolism 2007 (PubMed)

More Proteins for Tryptophan 2,3-Dioxygenase (TDO2) Interaction Partners

Human Tryptophan 2,3-Dioxygenase (TDO2) interaction partners

  1. Crystal tryptophan 2,3-dioxygenase structure revealed eight residues playing critical roles in L-tryptophan oxidation.

  2. IL-1beta (show IL1B Proteins) is suggested to stimulate tryptophan catabolism and production of IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins) by increasing TDO (show DLX3 Proteins) expression in endometriosis.

  3. Identification of 12 polymorphisms in the human TDO2 promoter region, 2 of them corresponding to previously unknown single-nucleotide polymorphisms and 3 of them located in putative glucocorticoid-responsive elements.

  4. TDO (show DLX3 Proteins) is highly expressed in the brains of Alzheimer disease patients.

  5. The data suggest that TDO (show DLX3 Proteins) uses a ring-opening mechanism during N-formylkynurenine formation, rather than Criegee or dioxetane mechanisms as previously proposed.

  6. subtle differences between the TDO (show DLX3 Proteins) and IDO (show IDO1 Proteins) reactions

  7. Polymorphism of tryptophan 2,3 dioxygenase gene is associated with autism.

  8. We found that astrocytes, neurons, and microglia expressed IDO (show IDO1 Proteins) but only microglia were able to produce detectable amounts of quinolinic acid. However, astrocytes and neurons had the ability to catabolize quinolinic acid.

  9. The tyrosine 42 of recombinant human TDO (show DLX3 Proteins) is responsible for the cooperative binding of l-Trp (show TBPL1 Proteins) by participating in the active site of the adjacent subunit.

  10. TDO (show DLX3 Proteins) mediates antimicrobial and immunoregulatory effects. TDO (show DLX3 Proteins)-dependent inhibition of T-cell growth might be involved in the immunotolerance observed in vivo during allogeneic liver transplantation.

Mouse (Murine) Tryptophan 2,3-Dioxygenase (TDO2) interaction partners

  1. both TDO and IDO (show IDO1 Proteins) biosynthesize nicotinamide from D-tryptophan and L-tryptophan in mice

  2. Data indicate that tryptophan 2,3-dioxygenase (Tdo2) may play an important role during mouse decidualization and be regulated by estrogen, progesterone, and cAMP.

  3. These findings demonstrate a direct molecular link between Trp (show TYRP1 Proteins) metabolism and neurogenesis and anxiety-related behavior under physiological conditions.

  4. Endometrial expression of TDO in epithelial and stromal cells is regulated by HOXA10 (show HOXA10 Proteins). Expression level of TDO influences infiltration of T-cells into endometrial stroma and thus may influence embryo viability.

  5. These findings indicate that TDO might be required at a late-stage of granule cell development, such as during axonal and dendritic growth, synaptogenesis and its maturation.

  6. No relationship was found between alcohol consumption, Tdo2 activity, and single nucleotide substitution in intron 6 of the Tdo2 gene assoiated with predisposition to alcoholism in humans.

  7. Our findings indicate that TDO and its novel variants may play an important role in not only the liver but also in local areas in developing and adult brain.

Tryptophan 2,3-Dioxygenase (TDO2) Protein Profile

Protein Summary

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene names and symbols associated with TDO2

  • tryptophan 2,3-dioxygenase b (tdo2b)
  • tryptophan 2,3-dioxygenase (tdo2)
  • tryptophan 2,3-dioxygenase (TDO2)
  • tryptophan 2,3-dioxygenase (MADE_02822)
  • tryptophan 2,3-dioxygenase (CtCNB1_3657)
  • tryptophan 2,3-dioxygenase a (tdo2a)
  • tryptophan 2,3-dioxygenase (CNC04830)
  • tryptophan 2,3-dioxygenase (tdo)
  • tryptophan 2,3-dioxygenase (Mrub_2119)
  • tryptophan 2,3-dioxygenase (Deipr_2235)
  • tryptophan 2,3-dioxygenase (Acav_1166)
  • tryptophan 2,3-dioxygenase (Mesop_4278)
  • tryptophan 2,3-dioxygenase (Tdo2)
  • tryptophan 2,3-dioxygenase (TDO)
  • AA407491 protein
  • chky protein
  • DDBDRAFT_0190495 protein
  • DDBDRAFT_0231363 protein
  • DDB_0190495 protein
  • DDB_0231363 protein
  • fb62b10 protein
  • fi30d08 protein
  • Tdo protein
  • tdo2 protein
  • tdo2l protein
  • TO protein
  • TPH2 protein
  • TRPO protein
  • wu:fb62b10 protein
  • wu:fi30d08 protein
  • zgc:63488 protein
  • zgc:103693 protein

Protein level used designations for TDO2

TDO-B , TO-B , TRPO-B , tryptamin 2,3-dioxygenase B , tryptophan 2,3-dioxygenase B , tryptophan 2,3-dioxygenase, like , tryptophan oxygenase B , tryptophan pyrrolase B , tryptophanase B , TDO , TO , TRPO , tryptamin 2,3-dioxygenase , tryptophan oxygenase , tryptophan pyrrolase , tryptophanase , tryptophan 2,3-dioxygenase , TDO-A , TO-A , TRPO-A , tryptamin 2,3-dioxygenase A , tryptophan 2,3-dioxygenase A , tryptophan oxygenase A , tryptophan pyrrolase A , tryptophanase A , tdo variant1 , tdo variant2 , tryptophan-2,3-dioxygenase , tryptophan-23-dioxygenase

GENE ID SPECIES
334082 Danio rerio
548450 Xenopus (Silurana) tropicalis
699739 Macaca mulatta
736252 Pan troglodytes
4456236 Ralstonia eutropha H16
4649802 Gramella forsetii KT0803
6776077 Alteromonas macleodii 'Deep ecotype'
8562285 Comamonas testosteroni CNB-2
100008541 Danio rerio
3256592 Cryptococcus neoformans var. neoformans JEC21
8617171 Dictyostelium discoideum AX4
8880228 Meiothermus ruber DSM 1279
10265555 Deinococcus proteolyticus MRP
10306071 Acidovorax avenae subsp. avenae ATCC 19860
10828127 Mesorhizobium opportunistum WSM2075
6999 Homo sapiens
475476 Canis lupus familiaris
56720 Mus musculus
64206 Rattus norvegicus
530397 Bos taurus
100344083 Oryctolagus cuniculus
100727713 Cavia porcellus
100301559 Sus scrofa
422409 Gallus gallus
495495 Xenopus laevis
Selected quality suppliers for Tryptophan 2,3-Dioxygenase Proteins (TDO2)
Did you look for something else?