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TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. Additionally we are shipping Tryptophan Hydroxylase 2 Antibodies (144) and Tryptophan Hydroxylase 2 Kits (18) and many more products for this protein.
Showing 7 out of 7 products:
tphR is expressed in serotonergic raphe neurons, similar to tph (show TPH1 Proteins) genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin
Association of TPH2 SNP with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively, was tested.
Carriers of the TPH-2 (show TDO2 Proteins) allele may be at increased risk for PTSD. COMT (show COMT Proteins) rs4633C and TPH-2 (show TDO2 Proteins) rs11178997T alleles jointly explained 7% of the variance in PTSD severity scores. These findings provide biological support for dividing DSM-IV category C symptoms into DSM-5 categories C and D.
Study demonstrated that 5-HTTLPR (show SLC6A4 Proteins), VNTR In2, and TPH2 (show TDO2 Proteins) rs1386497 polymorphisms mediate working memory performance and that their effects on working memory depend on cocaine use of participants
We also found that early family structure directly influences the levels of dysregulation problems in early adolescence, both alone and in interaction with TPH2 (show TDO2 Proteins).
Chinese Han individuals with at least oners11178997T allele or rs120074175A allele are susceptible to MD even in the relative absence of high-negative life events.
loss of function mutation in Tph2 (show TDO2 Proteins) results in greater motivation for ethanol consumption under aversive conditions and may confer enhanced sensitivity to alcohol use disorder
TPH2 (show TDO2 Proteins) expression is regulated by DNA methylation (show HELLS Proteins) of the TPH2 (show TDO2 Proteins) promoter region in patients with major depressive disorder.
results provide evidence for an association between the rs7305115 polymorphism of the TPH-2 (show TDO2 Proteins) gene and suicidal behavior in a Mexican population.
mood disorders and HTR1A (show HTR1A Proteins) G allele variation, the C-1019G polymorphism of the transcriptional control region of the 5-HT1A receptor (show HTR1A Proteins), independently predicted the incidence of IFN-induced depression in HCV patients
A potential role of TPH2 (show TDO2 Proteins) in alcohol dependencies suggested. TPH2 (show TDO2 Proteins) genetic variability may be also associated with anxiety and aggression traits in alcohol dependent subjects.
1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin (show LEP Proteins) genes: implication for behavioral influences of vitamin D.
No substantial differences in any parameter reflecting their firing activity both in vivo and in vitro were found in raphe nucleus 5-HT (show DDC Proteins) neurons of Tph2-/-, Tph2+/-, and Tph2+/+ mice
the C1473G polymorphism in the Tph-2 gene considerably influenced the changes in the expression patterns of genes involved in the regulation of neurogenesis and neural apoptosis induced by chronic ethanol treatment.
The results of this study suggests that Tph2(-/-) mice is a useful preclinical model to assess the role of 5-HT (show DDC Proteins)-dependent mechanisms in psychostimulants action.
both Tph2(-/-) male and female mice were resilient to chronic mild stress-induced hyperlocomotion
Litters born to and reared by TPH2-/- mothers showed decreased survival, lower weaning weights and increased cannibalization.
Decreased TPH2 activity cannot be considered a reliable predisposition factor for impaired emotional behavior: in conditions of reduced serotonin production a lowered serotonin degradation rate contributes to the maintenance of brain serotonin
This study showed that optogenetic activation of tryptophan hydroxylase 2-expressing serotonergic neurons in rostral ventromedial medulla in vivo induces a long-lasting pain sensitization measured as mechanical allodynia and thermal hyperalgesia. I
While total cell density in the anterior basolateral amygdala did not differ between genotypes, the number and density of the GABAergic interneurons were significantly decreased in Tph2(-/-) mice.
Females exhibit increased sensitivity to at least some of the effects of congenital 5-HT (show DDC Proteins) deficiency.
TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys
The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT (show DDC Proteins) metabolism, HPA (show HPSE Proteins) axis function, and aggressive behaviors
Study identified 17 single nucleotide polymorphisms; 3'-UTR polymorphisms were significantly associated with HPA (show HPSE Proteins) axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.
functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
, tryptophan hydroxylase 1, like
, tryptophan hydroxylase 2
, tryptophan hydroxylase D2
, neuronal tryptophan hydroxylase
, tryptophan 5-hydroxylase 2-like
, tryptophan 5-hydroxylase 2
, tryptophan 5-monooxygenase 2
, tryptophan hydroxylase-2
, tryptophan hydroxylase R