Tryptophan Hydroxylase 2 Proteins (TPH2)

TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. Additionally we are shipping Tryptophan Hydroxylase 2 Antibodies (147) and Tryptophan Hydroxylase 2 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPH2 121278 Q8IWU9
TPH2 216343 Q8CGV2
TPH2 317675 Q8CGU9
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Top Tryptophan Hydroxylase 2 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
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HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,371.50
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Yeast Macaca mulatta His tag   1 mg Log in to see 60 to 71 Days
$3,386.17
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Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
$3,389.83
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HOST_Escherichia coli (E. coli) Mouse GST tag,His tag   100 μg Log in to see 15 to 18 Days
$704.00
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TPH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Tryptophan Hydroxylase 2 (TPH2) Interaction Partners

Zebrafish Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe.

  2. tphR is expressed in serotonergic raphe neurons, similar to tph (show TPH1 Proteins) genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin

Chimpanzee Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. Association of TPH2 SNP with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively, was tested.

Human Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. This study demonstrates that both TPH1 (show TPH1 Proteins) and TPH2 (show TDO2 Proteins) are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development.

  2. This study provides the first evidence that, at least among Han Chinese patients with PD, AC genotype at rs78162420 in the TPH2 (show TDO2 Proteins) gene increase risk of depression.

  3. interaction between SNP rs4570625 and BDNF (show BDNF Proteins) Val66Met predicts a high-Risk emotional phenotype

  4. Subjects with the TPH2 (show TDO2 Proteins) rs4570625 TT genotype, especially males, exhibit less aggression and a favourable impulsivity profile, and develop anxiety disorders by young adulthood less often

  5. Study reports an association between functional variation on the TPH2 (show TDO2 Proteins) promotor region and rich club-a densely mutually connected set of hub regions in the brain, thought to serve as a processing and integration core-organization

  6. Altered TPH2 (show TDO2 Proteins) expression in colonic serotonergic nerves of patients with Hirschsprung's disease complicated by enterocolitis may contribute to intestinal secretory and motor disturbances, including recurrent HAEC.

  7. The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population. In single marker analyses,there was a significant difference in the genotype (chi (2) = 4.163, P = 0.041) and allele frequency (chi (2) = 3.930, P = 0.047) of rs1386494 between ODD and control groups.

  8. the association studies between TPH2 (show TDO2 Proteins) and Bipolar disorder was investigated.

  9. Carriers of the TPH-2 (show TDO2 Proteins) allele may be at increased risk for PTSD. COMT (show COMT Proteins) rs4633C and TPH-2 (show TDO2 Proteins) rs11178997T alleles jointly explained 7% of the variance in PTSD severity scores. These findings provide biological support for dividing DSM-IV category C symptoms into DSM-5 categories C and D.

  10. Study demonstrated that 5-HTTLPR (show SLC6A4 Proteins), VNTR In2, and TPH2 (show TDO2 Proteins) rs1386497 polymorphisms mediate working memory performance and that their effects on working memory depend on cocaine use of participants

Mouse (Murine) Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. This study demonstrated that tryptophan hydroxylase 2 Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas.

  2. No substantial differences in any parameter reflecting their firing activity both in vivo and in vitro were found in raphe nucleus 5-HT (show DDC Proteins) neurons of Tph2-/-, Tph2+/-, and Tph2+/+ mice

  3. the C1473G polymorphism in the Tph-2 gene considerably influenced the changes in the expression patterns of genes involved in the regulation of neurogenesis and neural apoptosis induced by chronic ethanol treatment.

  4. The results of this study suggests that Tph2(-/-) mice is a useful preclinical model to assess the role of 5-HT (show DDC Proteins)-dependent mechanisms in psychostimulants action.

  5. both Tph2(-/-) male and female mice were resilient to chronic mild stress-induced hyperlocomotion

  6. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin (show LEP Proteins) genes: implication for behavioral influences of vitamin D.

  7. Litters born to and reared by TPH2-/- mothers showed decreased survival, lower weaning weights and increased cannibalization.

  8. Decreased TPH2 activity cannot be considered a reliable predisposition factor for impaired emotional behavior: in conditions of reduced serotonin production a lowered serotonin degradation rate contributes to the maintenance of brain serotonin

  9. This study showed that optogenetic activation of tryptophan hydroxylase 2-expressing serotonergic neurons in rostral ventromedial medulla in vivo induces a long-lasting pain sensitization measured as mechanical allodynia and thermal hyperalgesia. I

  10. While total cell density in the anterior basolateral amygdala did not differ between genotypes, the number and density of the GABAergic interneurons were significantly decreased in Tph2(-/-) mice.

Rhesus Monkey Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys

  2. The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT (show DDC Proteins) metabolism, HPA (show HPSE Proteins) axis function, and aggressive behaviors

  3. Study identified 17 single nucleotide polymorphisms; 3'-UTR polymorphisms were significantly associated with HPA (show HPSE Proteins) axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.

  4. functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2

Tryptophan Hydroxylase 2 (TPH2) Protein Profile

Protein Summary

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Gene names and symbols associated with TPH2

  • tryptophan hydroxylase 1b (tph1b)
  • tryptophan hydroxylase 2 (TPH2)
  • tryptophan hydroxylase 2 (tph2)
  • tryptophan 5-hydroxylase 2-like (LOC100627725)
  • tryptophan hydroxylase 2 (Tph2)
  • tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) (tph2)
  • ADHD7 protein
  • AU043594 protein
  • Ntph protein
  • tph1l protein
  • tph2 protein
  • tphD2 protein
  • tphR protein
  • wu:fq15a04 protein

Protein level used designations for TPH2

tph1-2 , tryptophan hydroxylase 1, like , tryptophan hydroxylase 2 , tryptophan hydroxylase D2 , neuronal tryptophan hydroxylase , tryptophan 5-hydroxylase 2-like , tryptophan 5-hydroxylase 2 , tryptophan 5-monooxygenase 2 , tryptophan hydroxylase-2 , tph2a , tryptophan hydroxylase R

GENE ID SPECIES
415103 Danio rerio
467070 Pan troglodytes
100303678 Meleagris gallopavo
100459809 Pongo abelii
100486097 Xenopus (Silurana) tropicalis
100588345 Nomascus leucogenys
100627725 Sus scrofa
408026 Gallus gallus
121278 Homo sapiens
481165 Canis lupus familiaris
618062 Bos taurus
216343 Mus musculus
317675 Rattus norvegicus
100009100 Oryctolagus cuniculus
100336620 Bos taurus
100009684 Equus caballus
664730 Macaca mulatta
407712 Danio rerio
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