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Acts as a novel regulator of senescence. Additionally we are shipping and many more products for this protein.
Showing 10 out of 39 products:
Cow (Bovine) Polyclonal Ubinuclein 1 Primary Antibody for WB - ABIN2783062
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Human Monoclonal Ubinuclein 1 Primary Antibody for IP, WB - ABIN614815
Banumathy, Somaiah, Zhang, Tang, Hoffmann, Andrake, Ceulemans, Schultz, Marmorstein, Adams: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. in Molecular and cellular biology 2009
study points to UBN1 as the determinant of H3.3-specific binding and deposition by the HIRA (show HIRA Antibodies) histone chaperone complex.
NHRD domain of UBN1 as being an essential region for HIRA (show HIRA Antibodies) interaction and chromatin organization by the HUCA complex
a 184-amino acid region (from amino acids 39 to 223) at the N-terminal region of Ubn-1 was responsible for the interaction with the PDZ2 domain of ZO-1 (show TJP1 Antibodies)
Data show that, like HIRA (show HIRA Antibodies), UBN1, and ASF1a (show ASF1A Antibodies), CABIN1 (show CABIN1 Antibodies) is involved in heterochromatinization of the genome of senescent human cells.
By a chromatin immunoprecipitation (ChIP) assay, the authors show that Ubn-1 blocks EB1 (show MAPRE2 Antibodies)-human herpesvirus 4 DNA interaction.
Hpc2 (show ELAC2 Antibodies)-related domain of UBN1, UBN2, and Hpc2p is an evolutionarily conserved HIRA (show HIRA Antibodies)/Hir (show KCNJ4 Antibodies)-binding domain, which directly interacts with the N-terminal WD repeats of HIRA (show HIRA Antibodies)/Hir (show KCNJ4 Antibodies).
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly (By similarity).
, ubinuclein 1
, HIRA-binding protein
, ubiquitously expressed nuclear protein