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Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase Proteins (VHL)

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. Additionally we are shipping VHL Antibodies (112) and VHL Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse VHL VHL 22346 P40338
VHL 7428 P40337
Rat VHL VHL 24874 Q64259
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Top VHL Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,544.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$273.57
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

VHL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced VHL Proteins

  1. Human VHL Protein expressed in Wheat germ - ABIN1325000 : Kim, Lee, Jang, Yi, Kim, Han, Lee, Tong, Vincelette, Gao, Yin, Evans, Choi, Qin, Liu, Zhang, Deng, Jen, Zhang, Wang, Lou: WSB1 promotes tumor metastasis by inducing pVHL degradation. in Genes & development 2015 (PubMed)

More Proteins for Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Interaction Partners

Mouse (Murine) Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) interaction partners

  1. Loss of Vhl in mesenchymal progenitors of the limb bud caused severe fibrosis of the synovial joints and formation of aggressive masses with histologic features of mesenchymal tumors.

  2. These data suggested that intestinal epithelial cells were injured after IM treatment through the pVHL overexpression-induced degradation of collagen I or HIF-1alpha (show HIF1A Proteins).

  3. Vhl and Kif3a (show KIF3A Proteins) deletion accelerates renal cyst formation

  4. maintains the stability and suppressive function of Foxp3 (show FOXP3 Proteins)+ T cells via regulation of HIF-1a (show HIF1A Proteins) pathway

  5. Deletion of the Vhl gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia.

  6. Molecular dynamics of hif-1alpha (show HIF1A Proteins) and VHL may determine the success of antineoplastic strategies in hypoxia-reoxygenation as predicted by computational modeling.

  7. Loss of Vhl in adult joint cartilage is associated with earlier dysregulation of cartilage homeostasis, characterized by increased chondrocyte apoptosis, compromised chondrocyte autophagy and accelerated age-related and surgery-induced OA development.

  8. Both Vhl and Bap1 (show BAP1 Proteins) are required for kidney function. Even when Vhl is inactivated in multipotent nephron progenitor cells, Vhl loss is insufficient for renal tumorigenesis.

  9. VHL deficiency perturbs pancreas endocrine homeostasis in mice.

  10. data suggest that the VHL-mediated signaling in osteochondral progenitor cells plays a critical role in bone remodeling at postnatal/adult stages through coupling osteogenesis and angiogenesis

Human Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) interaction partners

  1. HBV induces the HIF2alpha (show EPAS1 Proteins) expression through its encoded protein HBx. This upregulates the HIF-2alpha (show EPAS1 Proteins) expression by binding to the pVHL activating the NF-kappaB (show NFKB1 Proteins) signaling pathway

  2. inhibition of miR566 expression increases the expression levels of VHL, decreases the expression levels of VEGF, and inhibits the invasive and migratory abilities of glioblastoma.

  3. proteome and phospho-proteomic analysis of isogenic 786-O renal cell carcinoma (show MOK Proteins) (+/-VHL) cells to compare signatures that reflect hypoxia and/or loss of VHL protein

  4. Pars (show EPRS Proteins) plana vitrectomy in advanced VHL eye disease can improve or preserve visual function, but postoperative progression of ocular VHL disease can be accelerated in cases where retinotomy is performed.

  5. AR-suppressed miRNA-145 is a key player in renal cell carcinoma (show MOK Proteins) progression by regulating HIF2alpha (show EPAS1 Proteins)/VEGF (show VEGFA Proteins)/MMP9 (show MMP9 Proteins)/CCND1 (show CCND1 Proteins) expression levels, irrespective of VHL status.

  6. VHL was shown to influence cellular metabolism through its effect on HIF proteins as well as by affecting activity of other factors.

  7. Data indicate that mutant VHL can protect HIF1alpha (show HIF1A Proteins) from SART1 (show SART1 Proteins)-dependent degradation in normoxic conditions, but this protection is lost in hypoxic settings, favoring hypoxia-dependent ccRCC proliferation.

  8. VHLp19 has a role for regulating EPO (show EPO Proteins) levels that VHLp30 does not have, whereas VHLp30 is really the tumor suppressor isoform.

  9. pVHL interacts with CERKL (show CERKL Proteins) and ubiquitinates it for oxygen dependent proteasomal degradation.

  10. APOE (show APOE Proteins), VHL and MTHFR (show MTHFR Proteins) gene polymorphisms were related to the risk of renal cell carcinoma (show MOK Proteins)

VHL Protein Profile

Protein Summary

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with VHL

  • von Hippel-Lindau tumor suppressor (Vhl)
  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL)
  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (Vhl)
  • HRCA1 protein
  • pVHL protein
  • RCA1 protein
  • VHL1 protein
  • Vhlh protein

Protein level used designations for VHL

pVHL , von Hippel-Lindau disease tumor suppressor , von Hippel-Lindau syndrome homolog , von Hippel-Lindau syndrome protein homolog , elongin binding protein , protein G7

GENE ID SPECIES
22346 Mus musculus
7428 Homo sapiens
24874 Rattus norvegicus
494000 Canis lupus familiaris
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