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WWP2 encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. Additionally we are shipping WWP2 Antibodies (40) and WWP2 Kits (6) and many more products for this protein.
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WWP2 may represent a novel diagnostic marker and molecular therapeutic target for liver cancer.
majority of ovarian carcinomas harbored homozygous or heterozygous deletions in WWP2 locus, and there was an inverse correlation in the expression levels between WWP2 and Notch3 (show NOTCH3 Proteins) in ovarian carcinomas
Data provide evidence that the stability of Paip1 (show PAIP1 Proteins) can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation.
Results identify WWP2 as a novel p73 (show TP73 Proteins)-associated protein that ubiquitinates and degrades p73 (show TP73 Proteins).
Wwp2 acts as a ubiquitin ligase of SRG3 (show SMARCC1 Proteins).
WWP2-N is downregulated in stage IIIC melanoma and up-regulated in stage II/III prostate cancer, and WWP2-FL and WWP2-C overexpression is associated with early-stage breast cancer.
Koala retrovirus Gag PPPY L-domain interacts with the WW domain(s) of WWP2 and progeny virions are released from cells by utilizing the multivesicular body sorting pathway.
WWP2 controls cellular apoptosis and is required for tumorigenicity of cells
Data show that the WWP2-N isoform interacts with Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins), whereas WWP2-C interacts only with Smad7 (show SMAD7 Proteins).
expression, binding, and functional data all suggest that WWP2 is a candidate to regulate ENaC (show SCNN1A Proteins)-mediated Na(+) transport in epithelia
Wwp2 acts as a ubiquitin ligase (show RNF123 Proteins) of SRG3 (show SMARCC1 Proteins).
WWP2 negatively regulates TLR3 (show TLR3 Proteins)-mediated innate immune and inflammatory responses by targeting TRIF (show RNF138 Proteins) for ubiquitination and degradation.
a number of miR (show MLXIP Proteins)-25 candidate gene targets
Data show that MiR (show MLXIP Proteins)-140 is co-expressed with Wwp2-C and is activated by Sox9 (show SOX9 Proteins) to target Sp1 (show SP1 Proteins) in maintaining chondrocyte proliferation.
ADAR2 (show ADARB1 Proteins) protein levels and catalytic activity are coordinately regulated in a positive manner by Pin1 (show PIN1 Proteins) and negatively by WWP2 and this may have downstream effects on the function of glutamate receptor 2 (show GRIA2 Proteins).
The regulatory interaction between Sox9 (show SOX9 Proteins), Wwp2 and Med25 (show MED25 Proteins) defines the Sox9 (show SOX9 Proteins) transcriptional mechanisms of chondrogenesis in the forming palate.
Studies demonstrate that Wwp2 influences craniofacial patterning through its interactions with Goosecoid (Gsc (show GSC Proteins)).
Wwp2-mediated Oct4 (show POU5F1 Proteins) poly-ubiquitination and its auto-ubiquitination occur through the Lys (show LYZ Proteins) 63 linkage and may be involved in down-regulation of Oct4 (show POU5F1 Proteins) protein levels.
These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.
DMT1 (show SLC11A2 Proteins) interacts with 2 WW domain-interacting proteins, Ndfip1 (show NDFIP1 Proteins) and Ndfip2 (show NDFIP2 Proteins). This promotes DMT1 (show SLC11A2 Proteins) ubiquitination and degradation by WWP2.
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.
NEDD4-like E3 ubiquitin-protein ligase WWP2
, WW domain-containing protein 2
, WW domain containing E3 ubiquitin protein ligase 2
, atrophin-1 interacting protein 2
, WW domain-containing protein 4