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ZNFN1A2 Proteins (ZNFN1A2)

ZNFN1A2 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping ZNFN1A2 Antibodies (59) and ZNFN1A2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZNFN1A2 22779 P81183
Rat ZNFN1A2 ZNFN1A2 301476  
ZNFN1A2 22807 Q9UKS7
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Top ZNFN1A2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ZNFN1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for ZNFN1A2 Interaction Partners

Mouse (Murine) ZNFN1A2 interaction partners

  1. Helios controls certain aspects of Treg-suppressive function, differentiation, and survival.

  2. this study reports that impaired expression of the transcription factor Helios by FoxP3 (show FOXP3 Proteins)+ CD4 (show CD4 Proteins) and Qa-1 (show H2-T23 Proteins)-restricted CD8 (show CD8A Proteins) Tregs results in defective regulatory activity and autoimmunity in mice.

  3. data suggest that a subset of DN T cells, identified by the expression of PD-1 (show PDCD1 Proteins) and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 (show CD8A Proteins) loss as a process associated with self-Ag encounter

  4. results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen

  5. identify Helios as the first marker known to diverge during positive and negative selection of thymocytes

  6. Helios regulates IL-2 (show IL2 Proteins) production in Tregs by suppressing Il2 (show IL2 Proteins) gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 (show IL2 Proteins) locus.

  7. Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons.

  8. In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass.

  9. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.

  10. down-regulation of NK cell activity by NKp46 (show NCR1 Proteins) was associated with the silencing of the Helios transcription factor in NK cells

Human ZNFN1A2 interaction partners

  1. The results show that high vs. low expression of Nrp-1 (show NELL1 Proteins) or Helios does not unequivocally identify Treg clones of thymic or peripheral origin.

  2. Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1 (show NELL1 Proteins).

  3. Forkhead box protein 3 (show HSPB3 Proteins)(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.

  4. The immunosuppressive enzyme IL4I1 (show IL4I1 Proteins) expressed differentially in human induced Aiolos (show IKZF3 Proteins)+, but not natural Helios+, FOXP3 (show FOXP3 Proteins)+ Treg cells.

  5. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros (show IKZF1 Proteins) promoted T-cell growth.

  6. Foxp3 (show FOXP3 Proteins)+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.

  7. large number of ex vivo expanded functional Treg can be obtained from long-term T1D patients, although fewer expanded Treg expressed a high level of Helios

  8. A differential role for monocyte subsets in control of Helios(+/-) Treg development that is mediated by distinct inflammatory cytokines.

  9. Although Ikaros (show IKZF1 Proteins) and Helios belong to the same family with similar structure of zinc fingers, their isoforms have different expression profiles, specific genetic alterations, and different clinical relevance in patients with leukemia.

  10. Helios+ and Helios- cells coexist within the natural FOXP3 (show FOXP3 Proteins)+ T regulatory cell subset in humans.

ZNFN1A2 Protein Profile

Protein Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Gene names and symbols associated with ZNFN1A2 Proteins (ZNFN1A2)

  • IKAROS family zinc finger 2 (Helios) (IKZF2)
  • IKAROS family zinc finger 2 (Helios) (ikzf2)
  • IKAROS family zinc finger 2 (Ikzf2)
  • A730095J18Rik protein
  • ANF1A2 protein
  • HELIOS protein
  • IKZF2 protein
  • Zfpn1a2 protein
  • ZNF1A2 protein
  • znfn1a1 protein
  • znfn1a1-a protein
  • Znfn1a2 protein

Protein level used designations for ZNFN1A2 Proteins (ZNFN1A2)

IKAROS family zinc finger 2 (Helios) , zinc finger protein, subfamily 1A, 2 (Helios) , ikaros family zinc finger protein 2 , zinc finger protein Helios , ikaros-related transcription factor , lymphoid transcription factor , zinc finger DNA binding protein Helios

GENE ID SPECIES
470634 Pan troglodytes
693521 Macaca mulatta
100144703 Xenopus (Silurana) tropicalis
22779 Mus musculus
301476 Rattus norvegicus
373693 Xenopus laevis
395309 Gallus gallus
22807 Homo sapiens
488510 Canis lupus familiaris
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