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serine Peptidase Inhibitor, Kunitz Type, 2 Proteins (SPINT2)

SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. Additionally we are shipping SPINT2 Antibodies (81) and SPINT2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SPINT2 SPINT2 292770  
SPINT2 10653 O43291
SPINT2 20733 Q9WU03
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Top SPINT2 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Human Cells Human ECD,Fc Tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$382.86
Details

SPINT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Mouse (Murine) , ,
,

Top referenced SPINT2 Proteins

  1. Human SPINT2 Protein expressed in Escherichia coli (E. coli) - ABIN1098709 : Bergum, List: Loss of the matriptase inhibitor HAI-2 during prostate cancer progression. in The Prostate 2010 (PubMed)
    Show all 2 references for ABIN1098709

More Proteins for serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) Interaction Partners

Human serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. study the methylation status of the promoter region of Serine peptidase inhibitor/hepatocyte growth factor activator inhibitor type 2 (SPINT2/HAI-2)

  2. It suggests an involvement of SPINT2 in PCa (show FLVCR1 Proteins) tumorigenesis, probably in association with a post-translational regulation of SPINT2.

  3. N-glycan branching regulates HAI-2 through different subcellular distribution and subsequently access to different target proteases

  4. Matriptase (show ST14 Proteins) inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells.

  5. Epigenetic silencing of SPINT2 promotes cancer cell motility in malignant melanoma.

  6. a missense mutation in the serine protease inhibitor SPINT2 may have a role in congenital sodium diarrhea

  7. results suggest that the SPINT2 underexpression in the MSC (show MSC Proteins) from MDS (show PAFAH1B1 Proteins) patients is probably involved in the adhesion of progenitors to the bone marrow niche, through an increased HGF (show HGF Proteins) and SDF-1 (show CXCL12 Proteins) signaling pathway.

  8. The role of hepatocyte growth factor activator (show HGFA Proteins) inhibitor-2 (HAI-2) in prostate cancer cell migration, invasion, tumorigenicity and metastasis.

  9. The tumor suppressor gene SPINT2 is commonly silenced by promoter hypermethylation in human esophageal squamous cell carcinoma and SPINT2 hypermethylation is correlated with poor overall survival.

  10. established SPINT2 as a second gene associated with congenital tufting enteropathy

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) interaction partners

  1. HAI-1 (show SPINT1 Proteins) regulates the activity of activated matriptase (show ST14 Proteins), whereas HAI-2 has an essential role in regulating prostasin (show PRSS8 Proteins)-dependent matriptase (show ST14 Proteins) zymogen activation.

  2. mutations in Prss8 (show PRSS8 Proteins) restored placentation and normal development of HAI-1 (show SPINT1 Proteins)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.

  3. HAI-1 (show SPINT1 Proteins) and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  4. Unlike HAI-1 (show SPINT1 Proteins) and matriptase (show ST14 Proteins), HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase (show ST14 Proteins)

  5. Inhibition of the transmembrane serine protease (show F2 Proteins) matriptase (show ST14 Proteins) (encoded by St14 (show ST14 Proteins)) is an essential function of HAI2 during tissue morphogenesis.

SPINT2 Protein Profile

Protein Summary

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPINT2

  • serine peptidase inhibitor, Kunitz type, 2 (Spint2)
  • serine peptidase inhibitor, Kunitz type, 2 (SPINT2)
  • serine protease inhibitor, Kunitz type 2 (Spint2)
  • AL024025 protein
  • C76321 protein
  • DIAR3 protein
  • HAI-2 protein
  • HAI2 protein
  • Kop protein
  • PB protein

Protein level used designations for SPINT2

hepatocyte growth factor activator inhibitor type 2 , placental bikunin , serine protease inhibitor, Kunitz type 2 , kunitz-type protease inhibitor 2 , serine protease inhibitor, Kunitz type, 2

GENE ID SPECIES
292770 Rattus norvegicus
10653 Homo sapiens
20733 Mus musculus
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