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the role of CD137 (show TNFRSF9 Proteins)-CRDI (cysteine rich domain I) in the binding of CD137 (show TNFRSF9 Proteins)-CD137L was further investigated.
Data indicate that anti-CD137 (show TNFRSF9 Proteins) agonists can function as inhibitors of CD137L signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.
Constitutive interaction between 4-1BB (show TNFRSF9 Proteins) and 4-1BBL on murine LPS (show TLR4 Proteins)-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS (show PTK6 Proteins)-1 but not 19H3 antibody.
4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues
These results demonstrate that 4-1BBL-engineered DCs can improve CIKs (show TRAF3IP2 Proteins) cytotoxicity against prostate cancer cells.
these observations suggest that inhibition of the TLR/4 (show TLR4 Proteins)-1BBL complex formation may be highly efficient in protecting against continued inflammation
4-1BB (show TNFRSF9 Proteins) mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.
CD137 (show TNFRSF9 Proteins)-CD137L interactions mediated via regulation of CyPA (show PPIA Proteins) contribute to the progression of atherosclerosis.
Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions.
monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB (show TNFRSF9 Proteins), and in conjunction with this pathway, maintain their numbers at baseline.
blocking of both OX-40L (show TNFSF4 Proteins) and 4-1BBL reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.
CD137L is overexpressed in non-small cell lung cancer specimens and positive expression of CD137L was associated with better overall survival.
In vitro immunotherapy is described for anti-prostate cancer effects of cytotoxic T lymphocytes induction by recombinant adenovirus mediated PSMA/4 (show PSMA4 Proteins)-1BBL dendritic cells.
vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3 (show CD3 Proteins)+CD8 (show CD8A Proteins)+ TIL (show TLR1 Proteins) and NK cells, decreased the number of FOXP3 (show FOXP3 Proteins) cells and inhibited the development of DMH (show DST Proteins)-induced colorectal cancer
Elevated plasma levels and monocyte-associated expression of CD137 (show TNFRSF9 Proteins) ligand in patients with acute atherothrombotic stroke
Hence, the targeted combination of IL-15 (show IL15 Proteins) and 4-BBL (show TP53 Proteins) in the form of a trifunctional antibody-fusion protein is a promising new approach for cancer immunotherapy.
TIRAP (show TIRAP Proteins) and IRAK2 (show IRAK2 Proteins) are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4 (show TLR4 Proteins)-1BBL complex.
this is the first study to indicate that this member of the TNF (show TNF Proteins) superfamily, CD137 (show TNFRSF9 Proteins), is modulated by SAHA treatment in breast
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
, tumor necrosis factor (ligand) superfamily, member 9
, 4-1BB ligand
, tumor necrosis factor ligand superfamily member 9
, homolog of mouse 4-1BB-L
, receptor 4-1BB ligand