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Chicken Monoclonal CDC5L Primary Antibody for BI, WB - ABIN968837
Ajuh, Kuster, Panov, Zomerdijk, Mann, Lamond: Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. in The EMBO journal 2000
Show all 4 Pubmed References
Human Polyclonal CDC5L Primary Antibody for FACS, WB - ABIN652896
Grillari, Löscher, Denegri, Lee, Fortschegger, Eisenhaber, Ajuh, Lamond, Katinger, Grillari-Voglauer: Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Study demonstrates that the levels of Prp19 (show PRPF19 Antibodies) and Cdc5L are overexpressed in hepatocellular carcinoma (HCC (show FAM126A Antibodies)). Prp19 (show PRPF19 Antibodies) binds with Cdc5L and its downregulation results in reduction of Cdc5L. Mechanistic insights reveal that silencing Prp19 (show PRPF19 Antibodies) compromises translation activity of Cdc5L and facilitates lysosome-induced degradation of Cdc5L in HCC (show FAM126A Antibodies) cells.
CDC5L might play an important role in glioma cell survival and disease progression.
Cdc5L was highly expressed in hepatocellular carcinoma. Overexpression of Cdc5L favors cell cycle progress of HCC (show FAM126A Antibodies) cells, while downregulation of Cdc5L results in cell cycle arrest at G2/M phase and reduced cell proliferation of HCC (show FAM126A Antibodies) cells.
The results show that CTNNBL1 (show CTNNBL1 Antibodies) enhances the association of CWC15 (show CWC15 Antibodies) and CDC5L, both core Prp19 (show PRPF19 Antibodies) complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 (show CTNNBL1 Antibodies) or CWC15 (show CWC15 Antibodies) suggesting the two proteins might exchange places in the complex.
Cdc5L is a key regulator of mitotic progression.
The N-terminal ARM-repeat domain of CTNNBL1 (show CTNNBL1 Antibodies) provides a binding site for CDC5L, a binding partner in the Prp19 (show PRPF19 Antibodies)-CDC5L complex.
CTNNBL1 (show CTNNBL1 Antibodies) is a novel nuclear localization sequence-binding protein (show NSR1 Antibodies) that recognizes RNA-splicing factors CDC5L and Prp31 (show PRPF31 Antibodies)
Dbf4 (show DBF4 Antibodies) regulates the Cdc5 Polo-like kinase (show PLK1 Antibodies) through a distinct non-canonical binding interaction
A central region in hnRNP-M (show HNRNPM Antibodies) is required for interaction with CDC5L/PLRG1 (show PLRG1 Antibodies).
Blom7alpha is a novel splicing factor (show SLU7 Antibodies) of the K homology domain family that might be implicated in alternative splicing by helping to position the CDC5L-SNEV(Prp19-Pso4 (show PRPF19 Antibodies)) complex at the splice sites
Results suggest that CDC5 may have dual roles in miRNA biogenesis: functioning as a positive transcription factor of MIR (show MYLIP Antibodies) and/or acting as a component of the DICER (show DICER1 Antibodies)-LIKE1 complex to enhance primary miRNA processing.
Silencing of AtCDC5 in wild-type plants all induces cell death.
These results suggest that AtCDC5 is essential for the G2/M phase transition and may regulate the function of SAM by controlling the expression of STM and WUS.
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.
cell division cycle 5-like protein
, CDC5 cell division cycle 5-like (S. pombe)
, CDC5 cell division cycle 5-like
, Cell division cycle 5-like protein
, cell division cycle 5-like protein-like
, cdc5-like protein
, Cdc5-related protein
, dJ319D22.1 (CDC5-like protein)
, pombe cdc5-related protein
, cell division cycle 5-related protein
, pombe Cdc5-related protein